Tight junction protein-1
A Protein Kinase A-Dependent Mechanism by Which Rotavirus Affects the Distribution and mRNA Level of the Functional Tight Junction-Associated Protein, Occludin, in Human Differentiated Intestinal Caco-2 Cells
... by translocation of the catalytic sub- unit of PKA into the nucleus, where it phosphorylates and activates activating and silencing transcription factors, both of which can target responsive element sites present in a ...
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Original Article Expression of apoptosis signal-regulating kinase 1 is associated with tight junction protein claudin-6 in cervical carcinoma
... main protein components of tight junction are often altered in human tumors ...a tight junctional protein, as a potential breast cancer suppres- sor gene, which contributed to the ...
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Regulation of the Intestinal Barrier in Digestive Disease.
... of tight junctions, the ZO-1/ZO-2/ZO-3 complex interacts with the transmembrane proteins occludin and claudins as well as the cytoplasmic proteins actin, AF-6, the kinase ZAK (Figure 1) ...the ...
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Comparison of Subtyping Approaches and the Underlying Drivers of Microbial Signatures for Chronic Rhinosinusitis
... measured tight junction proteins in this study, only ZO-1 was signifi- cantly downregulated in DC2 relative to the expression in ...the tight junction complex (30, ...of tight ...
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Developmental Profile of Claudin-3, Claudin-5, and Claudin-16 Tight Junction Proteins in the Chick Intestine.
... In the chick intestine, Cla5 expression was seen in the cell-to-cell contact regions in the crypt and lower parts of the villi and in the terminal web regions. In the small intestine one of the primary functions of the ...
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Density-enhanced protein tyrosine phosphatase 1 (DEP-1) regulation of epithelial cell adhesions
... and β-catenin (80, 149), and we have confirmed these interactions (Fig. 2.1B and data not shown). However, we found that DEP-1 does not bind all tyrosine phosphorylated junctional proteins (Fig. 2.1B). It is ...
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Diesel exhaust particles modulate the tight junction protein occludin in lung cells in vitro
... and protein in EC did not change, although the TEER values decreased after DEP ...respective protein because it is unclear if the mRNA is degraded or trans- ...of protein, however the physio- logical ...
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claudin 10 isoform expression and cation selectivity change with salinity in salt secreting epithelia of Fundulus heteroclitus
... (Cldn) tight junction (TJ) protein contributions to branchial salt secretion in marine teleost fishes, this study examined cldn-10 TJ protein isoforms of a euryhaline teleost (mummichog; ...
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HIV 1 Tat protein alter the tight junction integrity and function of retinal pigment epithelium: an in vitro study
... fied version of the technique of Hartnett et al [23]. Briefly, to assess the fluid flux across the monolayer, sodium flu- orescein mixed in DMEM (25 mg/ml sodium fluorescein) was added to the apical compartment of the ...
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Overexpression of caveolin-1 attenuates brain edema by inhibiting tight junction degradation
... To the best of our knowledge, we report for the first time a beneficial effect of Cav-1 OE on brain edema and BBB disruption following the induction of ischemia with MCAO. The results presented here highlight ...
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Contribution of JAM 1 to epithelial differentiation and tight junction biogenesis in the mouse preimplantation embryo
... these models, cell fate diversification can occur by atypical PKC phosphorylation of cytoskeletal components, resulting in different inheritance of determinant proteins (Betschinger et al., 2003). Similar to the current ...
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Upregulation of the tight junction protein occludin: effects on ventilation-induced lung injury and mechanisms of action
... and protein concentration was determined using a bicinchoninic acid protein assay kit ...of protein were denatured and separated on 10% SDS-PAGE gels and then transferred to polyvinylidene difluoride ...
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The roles of tumor necrosis factor-alpha in colon tight junction protein expression and intestinal mucosa structure in a mouse model of acute liver failure
... There was no any damage on TJs and no decrease in the expression of ZO-1 on the mice group accepted recom- binant TNF-α, the purpose of this study was to discolse the change of TJ in ALF process, a positive ...
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Hepatitis C Virus Induces CD81 and Claudin-1 Endocytosis
... represent tight junctions and suggested that HCV engagement of CD81 would prime the movement of virus to tight-junction-associated entry factors claudin-1 and occludin in a manner similar to ...
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Mouse Adenovirus Type 1 Early Region 1A Effects on the Blood-Brain Barrier
... type 1 (MAV-1) infects endothelial cells and disrupts the blood-brain barrier (BBB), causing encephalitis in inbred and outbred ...1A protein E1A, we inves- tigated whether the activity of this known ...
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243.full.pdf
... ZO-1 is the founding member of the ZO family that also includes ZO-2 and ZO-3 (also known as TJP2 and TJP3, respectively). Each of these proteins contains multiple domains with numerous known and putative binding ...
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Tight Junction Protein Occludin Is a Porcine Epidemic Diarrhea Virus Entry Factor
... infection. Tight junctions correlate with the maintenance of the paracellular barrier function in epithelial cells even when epithelial cells divide (36, ...altered tight junction proteins ...
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Claudin 5: Gatekeeper of neurological function
... of tight junction proteins [97, ...the tight junction occurs within 10 min of TEM with discontinu- ous claudin-5 staining in areas of monocyte TEM ...
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Brazilian propolis mitigates impaired glucose and lipid metabolism in experimental periodontitis in mice
... Periodontal diseases are mainly chronic infectious dis- eases resulting from responses to a complex dental plaque microbiome containing various periodonto- pathic bacteria species. Epidemiological studies sug- gest that ...
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Identification of the first large deletion in the CLDN16 gene in a patient with FHHNC and late-onset of chronic kidney disease: case report
... Functional assays have revealed that different mutant proteins can display normal trafficking to the cell mem- brane or remain in the cell, localized either to lysosomes or to the endoplasmic reticulum. Moreover, even ...
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