TIMP-1 and TIMP-2
Elevated serum concentrations of metalloproteinases (MMP-2, MMP-9) and their inhibitors (TIMP-1, TIMP-2) in patients with Graves’ orbitopathy
... concentrations of MMP-2 and MMP-9, and their inhibi- tors, TIMP-1 and TIMP-2, in patients with GD, with and without GO, both in the active phase and after successful treatment. We ...
5
Evaluation of MMP-9 and MMP-2 and their suppressor TIMP-1 and TIMP-2 in adenocarcinoma of esophagogastric junction
... of TIMP-1 is not only carcinoma cells per se but also macrophages or fibroblasts around tumor nests; the diversity of methodology in detection of TIMP-1 and the heterogeneity of cancers among ...
7
<p>MMP-2, MMP-9, TIMP-1, and TIMP-2 in the Peripheral Blood of Patients with Differentiated Thyroid Carcinoma</p>
... Zn 2+ active center of MMPs, while its C-terminal functional area forms bonds with other parts of MMPs at a proportion of 1:1 to form the MMP-TIMP ...(i.e., TIMP-1, ...
7
Expression of the metalloproteases MMP 1, MMP 2, MMP 3, MMP 9, MMP 11, TIMP 1 and TIMP 2 in angiocentric midfacial lymphomas
... From 31 cases previously studied, 20 nasal type lympho- mas were identified as T/NK cells EBV positive from National Cancer Institute of Mexico and used for this study. From this series, 13 were men and seven were women ...
9
Alterations in fibrinolytic system proteins PAI 1, MMP 3, MMP 8, TIMP 1 and TIMP 2 in post cholecystectomy bile duct injury
... serum TIMP-1 and MMP-8, which emphasize the imbalance between the pro-fibro- genic/fibrinolytic ...a 1:1 stoichiometric complex in the catalytic domain of the MMPs and thus blocking MMPs; even ...
10
Aging is associated with increased activities of matrix metalloproteinase 2 and 9 in tenocytes
... both TIMP-1 and TIMP-2 mRNA expressions were decreased in old tenocytes, suggesting the activities of MMP-2 and −9 in old tenocytes, under less inhibitory effect from ...
7
Acute exacerbations of COPD are associated with significant activation of matrix metalloproteinase 9 irrespectively of airway obstruction, emphysema and infection
... from 2–10 days (mean of 7 ...12, TIMP-1 and TIMP-2 in BAL by the time lapse from the onset of the exacerbation (1–3, 4–6 and 7–10 days), we did not observe significant ...
12
Activation and localization of matrix metalloproteinase 2 and 9 in the skeletal muscle of the muscular dystrophy dog (CXMDJ)
... of TIMP-1 and TIMP-2 mRNA levels were not different between inflammatory myopathies/inclusion body myositis and muscular dys- trophy ...both TIMP-1 and TIMP-2 mRNA ...
11
Low Levels of Tissue Inhibitors of Metalloproteinases With a High Matrix Metalloproteinase-9/Tissue Inhibitor of Metalloproteinase-1 Ratio Are Present in Tracheal Aspirate Fluids of Infants Who Develop Chronic Lung Disease
... MMP-9, TIMP-1, and TIMP-2 from birth to the development of CLD in TAF of ventilated preterm ...of TIMP-1 with a high MMP-9/TIMP-1 ratio in the first 2 weeks ...
8
Circulating matrix metalloproteinase MMP-9 and MMP-2/TIMP-2 complex are associated with spontaneous early pregnancy failure
... since TIMP should inhibit their invasiveness. TIMP-1 and TIMP-2 are considered to be responsible for protecting vessels and maintaining blood vessels’ integrity as inhibitors of MMPs ...
6
Matrix metalloproteinase 2 level in human follicular fluid is a reliable marker of human oocyte maturation in in vitro fertilization and intracytoplasmic sperm injection cycles
... MMP-9, TIMP-1 and TIMP-2 was shown to be associated with follicular health ...follicular TIMP-1, but not TIMP-2, level was detected compared with that in the ...
8
Circulating levels of matrix proteases and their inhibitors in pregnant women with and without a history of recurrent pregnancy loss
... and TIMP activity in several tissues ...(MMP-9), TIMP-1 and TIMP-2 in aliquots of serum stored from women with a history of RPL and age- matched pregnant controls without a previous ...
9
Original Article Effect of Bisphenol A on invasion ability of human trophoblastic cell line BeWo
... methyltransferase 1 (DNMT1) is an enzyme, characterized for its role in maintaining DNA methylation patterns during replication and involved in transcription- al repression ...and TIMP-2) were ...
10
Imbalance of tissue inhibitors of metalloproteinases (TIMP) – 1 and – 4 serum levels, in patients with inflammatory bowel disease
... Inflammatory bowel diseases (IBD), are characterized by an inflammatory cascade of mediators capable of degrad- ing and modifying bowel wall structure as well as induc- ing the formation of chronic inflammatory lesions ...
8
Matrix Metalloproteinases and Tissue Inhibitors of Matrix Metalloproteinases as Plasma Indicators of Bovine Cystic Ovarian Disease
... and TIMP-2 was lower in non-cystic compared to cystic cows, no significant differences were observed in MMP-2 and -9 and TIMP-1 and -2 due to cyst ...the ...
10
Growth-stimulatory activity of TIMP-2 is mediated through c-Src activation followed by activation of FAK, PI3-kinase/AKT, and ERK1/2 independent of MMP inhibition in lung adenocarcinoma cells
... experiments, TIMP-2 appeared to have the maximal effect on cell proliferation when used in pM concentrations with sparse cell ...of TIMP-2 decreased as cell-cell contact increased (data not ...
18
A dual role for microglia in promoting tissue inhibitor of metalloproteinase (TIMP) expression in glial cells in response to neuroinflammatory stimuli
... that TIMP expression is more strongly associated with astrocytes than microglia ...that TIMP-1 expression is astrocyte-specific, and this expression is highly upregulated during neuroinflammatory ...
10
Effects of radioiodine administration on serum concentrations of matrix metalloproteinases, adiponectin and thrombospondin-1
... Recent studies [13,14], demonstrated that even sub- clinical thyrotoxicosis may be independently associated, with an increased cardiovascular morbidity and mortal- ity, though there are still several issues pertaining ...
7
TIMP-2 modulates cancer cell transcriptional profile and enhances E-cadherin/beta-catenin complex expression in A549 lung cancer cells
... whereas TIMP-2 and Ala+TIMP-2 overexpressing cells were resistant to chronic EGF treatment (3 and 5 days) ...A549 TIMP- 2 and Ala+TIMP-2, compared to EV cells ...
11
Clinical features of a novel TIMP-3 mutation causing Sorsby's fundus dystrophy: implications for disease mechanism
... The five mutations previously identified in patients with Sorsby’s fundus dystrophy are in the carboxy terminal domain and all lead to cysteine substitutions (S156C, G166C, G167C, Y168C, S181C). It is likely that these ...
5