Tissue fibrosis
Evidence that fibroblasts derive from epithelium during tissue fibrosis
... Most investigators accept the conventional wisdom that fibroblasts represent a cell type of limited diversi- ty. Fibroblast shape, cytoskeletal structure, secretion of interstitial collagens, mobility, participation in ...
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Deciphering the cellular interplays underlying obesity induced adipose tissue fibrosis
... adipose tissue fibrosis ...adipose tissue inflammation (105) involves TLR4 activation on leukocytes, which in turn may secrete factors critical for the promotion of ...adipose tissue ...
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T cell costimulation blockade is effective in experimental digestive and lung tissue fibrosis
... calibration was made on the acquisition Rigaku software: a water-filled 1.5-mL tube inside a 2-mL tube was scanned. Based on full-stack histograms of a manually delimited volume of interest containing only water or air, ...
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Lymphoid tissue fibrosis is associated with impaired vaccine responses
... group is unknown but is likely related to frequent endemic infec- tions like malaria, TB, salmonella, and helminths. However, with these data we cannot exclude other factors that may contribute to TZ fibrosis and ...
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Fat fibrosis: friend or foe?
... of tissue hypoxia, adipocyte progenitors and fibroblasts exposed to activated macrophages secrete ECM, thereby promoting fibrosis during the development of ...adipose tissue blood flow, subcutaneous ...
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CD8+ T lymphocytes in bronchoalveolar lavage in idiopathic pulmonary fibrosis
... of tissue injury in IPF [5-8]. Recently, we shown that in IPF tissue, infiltrat- ing CD 8+ TLs are associated with the grade of dyspnoea and physiological indices of disease severity, implicating that they ...
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PDGFRα controls the balance of stromal and adipogenic cells during adipose tissue organogenesis
... Adipose tissue is distributed in depots throughout the body with specialized roles in energy storage and ...adipose tissue fibrosis in adult ...adipose tissue organogenesis is ...adipose ...
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Quantitative proteomic characterization of lung tissue in idiopathic pulmonary fibrosis
... pulmonary fibrosis (IPF) is a progressive disease that is the most common and lethal type of idi- opathic interstitial ...scarring fibrosis with a median survival of 2–3 years after diagnosis and has an ...
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Fibrosis in connective tissue disease: the role of the myofibroblast and fibroblast epithelial cell interactions
... connective tissue diseases (CTDs) and is the hallmark of scleroderma (systemic sclerosis ...disease, fibrosis affects not only the skin but also internal organs such as lungs and kidneys, leading to organ ...
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The Effect of Vernonia amygdalina on Chloroquine- induced Cardiotoxicity in Adult Wistar Rats
... In the present study, the level of Glutathione was significantly increased as compared with the control group but there was no difference when compared with the other treatment groups. This result is contrary to findings ...
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... Myocarditis is an inflammatory disease of myocard with varied onset and clinical presentation which lead to diagnosis difficulties. These difficulties often cause incoming patients with acute condition are not diagnosed ...
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Pancreatic hamartoma: a case report and literature review
... The epithelial cells of the ducts expressed cytokeratin 7 and cytokeratin 19, but were negative for cytokeratin 20. The adipose tissue was positive for S-100 protein, and mostly negative for MIB-1 (Ki-67). These ...
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Lymphocyte aggregates persist and accumulate in the lungs of patients with idiopathic pulmonary fibrosis
... lung tissue samples consisting of a surgical lung biopsy obtained early in the course of disease and lung explant tissue obtained at the time of end-stage ...
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Off-label use of tocilizumab to treat non-juvenile idiopathic arthritis in pediatric rheumatic patients: a literature review
... Takayasu arteritis (TA) is a granulomatous vasculitis involving the aorta and its main branches, and occurs in both adult and children [33]. TA manifests as constitu- tional symptoms such as weight loss and anorexia, and ...
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Post-tuberculous fibrosing mediastinitis: a review of the literature
... A fluorodeoxyglucose-positron emission tomog- raphy (FDG-PET) scan (see figure 2A,B) revealed a metabolically active partially calcified hilar and medias- tinal soft tissue mass with activity. The patient ...
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Changes in the gastric enteric nervous system and muscle: A case report on two patients with diabetic gastroparesis
... tochemistry six different antibodies were used following the same protocol outlined below. The antibodies used were a polyclonal rabbit anti-human protein gene product 9.5 (PGP 9.5) (1:2000, AbD Serotec, Oxford, UK), ...
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Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome wide association study
... AstraZeneca, Boehringer Ingelheim, Merck Frosst Centre for Therapeutic Research, Novartis, Regeneron, and Sanofi Aventis. WT reports grants from Merck and the Dutch Asthma Fund; personal fees from Pfizer, GSK, Chiesi, ...
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CD8+ T lymphocytes in lung tissue from patients with idiopathic pulmonary fibrosis
... appears to suggest that lymphocytes do play a role in fibrosis [4]. Furthermore, studies on BAL lymphocytes have shown that CD 8+ TLs are prominent in BAL in IPF [36] and may also be associated with a worse ...
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Effects of phosphodiesterase 4 inhibition on bleomycin-induced pulmonary fibrosis in mice
... and tissue remodeling ...sue fibrosis by partial elimination of pro-fibrotic environ- ment, for instance by suppression of inflammatory cells infiltration, downregulation of TNF-α and stimulation of IL-6 ...
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Assessment of Angiotensin-Converting Enzyme Gene in Idiopathic Pulmonary Fibrosis
... This study assessed the association of I/D polymorphism of the ACE gene in interstitial pulmonary fibrosis. There are few studies about the association of ACE gene polymorphism and IPF due to the rarity of disease ...
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