Tissue transglutaminase
Cross linking of the dermo epidermal junction of skin regenerating from keratinocyte autografts Anchoring fibrils are a target for tissue transglutaminase
... purified tissue transglutaminase, MDC was extensively cross-linked to a network of fibrils in the neodermis 7 d pg and later ...by transglutaminase are available in the newly deposited matrix, ...
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Protein kinase C delta is a substrate of tissue transglutaminase and a novel autoantigen in coeliac disease
... Abstract Post-translational modification of proteins by deamidation or transamidation by tissue transglutaminase (tTG) has been suggested as a possible mechanism for the development of autoimmunity. ...
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Plasmodium falciparum liver stage antigen 1 is cross linked by tissue transglutaminase
... hepatocytes and undergo pre-erythrocytic developmental schizogony forming tens of thousands of merozoites per hepatocyte. Shortly after hepatocyte invasion, the parasite starts to produce Liver Stage Antigen-1 (LSA-1), ...
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Immunoglobulin G (IgG) Anti-Tissue Transglutaminase Antibodies Used as Markers for IgA-Deficient Celiac Disease Patients
... anti-tissue transglutaminase antibodies (IgA-tTG) as predictors of untreated celiac disease (CoD) is well documented, and the presence and levels of these antibodies are most accurately monitored with ...
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Review Article Tissue Transglutaminase, Protein Cross-linking and Alzheimer’s Disease: Review and Views
... that tissue transglutaminase (tTG), which catalyzes the cross-linking of a wide spectrum of proteins including Aβ, tau, α-synuclein and neurofilament proteins, may be involved in protein aggregation in ...
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Performance of Antibodies against Tissue Transglutaminase for the Diagnosis of Celiac Disease: Meta-Analysis
... Due to the high prevalence of oligosymptomatic celiac disease (CD), the use of serological diagnostic assays becomes extremely useful in clinical practice, eliminating the performance of need- less intestinal biopsies. ...
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Monocyte-derived tissue transglutaminase in multiple sclerosis patients: reflecting an anti-inflammatory status and function of the cells?
... Background: Leukocyte infiltration into the central nervous system is an important feature of multiple sclerosis (MS) pathology. Among the infiltrating cells, monocytes comprise the largest population and are considered ...
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Anti-Endomysial and Anti-Tissue Transglutaminase Serological Test Compared with Small Bowel Biopsy in the Diagnosis of Celiac Disease
... 21. Donaldson MR, Book LS, Leiferman KM, Zone JJ, Neuhausen SL. Strongly positive tissue transglutaminase antibodies are associated with Marsh 3 histopathology in adult and pediatric celiac disease. J Clin ...
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In vivo evaluation of two tissue transglutaminase PET tracers in an orthotopic tumour xenograft model
... Background: The protein cross-linking enzyme tissue transglutaminase (TG2; EC 2.3.2.13) is associated with the pathogenesis of various diseases, including cancer. Recently, the synthesis and initial ...
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"Tissue" transglutaminase in animal development
... fication of proteins by establishing ε ( γ -glutamyl)lysine cross-linkings and/or covalent incorporation of di- and poly-amines into proteins (Folk and Finlayson, 1977; Folk, 1980; Greenberg et al., 1992). However, it ...
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Tissue transglutaminase in astrocytes is enhanced by inflammatory mediators and is involved in the formation of fibronectin fibril-like structures
... progresses. Tissue transglutaminase (TG2), a Ca 2+ -dependent enzyme that can cross-link proteins, appears in astrocytes in inflammatory MS lesions and may contribute to ...
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Original Article Auxo-action of tissue transglutaminase 2 on tumors in hepatitis B virus-related HCC
... Abstract: It has been reported that tissue transglutaminase-2 (TGM2) possesses the potential to assist in early diagnosis of HCC. The aim of this study was to explore the effects of TGM2 expression on ...
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Maternal celiac disease autoantibodies bind directly to syncytiotrophoblast and inhibit placental tissue transglutaminase activity
... villous tissue were dissected from term placenta obtained within 30 min of delivery and incubated in a biotinylated acyl donor substrate pep- ...placental tissue was preincubated with monoclonal anti-tTG or ...
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Tissue transglutaminase 2 expression is epigenetically regulated in human lung cancer cells and prevents reactive oxygen species-induced apoptosis
... Materials and methods: We investigated the TG2 expression and activity in A549, H1299, H1355, and H460 lung cancer cells by Western blots and quantitative polymerase chain reac- tion assay. The enzyme-linked ...
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Tissue Transglutaminase Enzyme-Linked Immunosorbent Assay as a Screening Test for Celiac Disease in Pediatric Patients
... Such studies report patients with positive serum IgA-EMA but normal biopsies who later developed biopsy-confirmed CD. Of interest, 1 of the 2 patients in our GI group that initially had a positive tTG and EMA, 2 years ...
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Tissue transglutaminase as a central mediator in inflammation induced progression of breast cancer
... To summarize, we propose that sustained expression of TG2 serves as a central mediator in infl ammation- induced progression of breast cancer by conferring cell survival and invasive competence on breast cancer cells ...
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Contribution of tissue transglutaminase to the severity of hepatic fibrosis resulting from Schistosoma japonicum infection through the regulation of IL 33/ST2 expression
... rigorously established the role of tTG in the pathogenesis of liver fibrosis by using in parallel a genetic approach, tTG knockout mice, and a biochemical approach, the injection of cystamine, a selective inhibitor of ...
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Designing Conformational Control of Human Tissue Transglutaminase
... retained transglutaminase activity ...increased transglutaminase activity plays no role in the pathogenic effects of celiac antibodies, but this is doubtful considering results that found that the ...
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Can Tissue Transglutaminase Antibody Titers Replace Small-Bowel Biopsy to Diagnose Celiac Disease in Select Pediatric Populations?
... Only 6 of 11 patients with a family history of celiac disease in a first-degree relative demonstrated posi- tive biopsy results, as opposed to 12 of 16 patients with a history of autoimm[r] ...
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Prevalence and Clinical Significance of Immunoglobulin A Antibodies against Tissue Transglutaminase in Patients with Diverse Chronic Liver Diseases
... The prevalence of celiac disease (CD) and the prevalence and clinical significance of anti-tissue transglu- taminase (tTG) antibodies (tTGAbs) in a large series of patients with chronic liver diseases were ...
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