tissue-type plasminogen activator
Thrombolysis with human extrinsic (tissue type) plasminogen activator in dogs with femoral vein thrombosis
... (tissue-type) plasminogen activator (plasminogen activator) was isolated either as a single-chain or as a two-chain molecule from the culture medium of a human melanoma cell ...
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Ultrasound-targeted transfection of tissue-type plasminogen activator gene carried by albumin nanoparticles to dog myocardium to prevent thrombosis after heart mechanical valve replacement
... Background: There are more than 300,000 prosthetic heart valve replacements each year worldwide. These patients are faced with a higher risk of thromboembolic events after heart valve surgery and long-term or even ...
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Regulation of seizure spreading by neuroserpin and tissue type plasminogen activator is plasminogen independent
... Tissue-type plasminogen activator (tPA) is a highly specific serine proteinase expressed in the CNS during events that require neuronal ...contrast, plasminogen-deficient mice show a ...
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Tissue-Type Plasminogen Activator, Plasminogen Activator Inhibitor, and Histidine-Rich Glycoproteins in Stressed Human Newborns
... Tissue-type plasminogen activator antigen was determined by an enzyme-linked immuno- sorbent assay (ELISA) method using a commercial kit (Imubind-5- tPA, American Diagnostica).4’9 Plasmi[r] ...
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Tissue type plasminogen activator is a neuroprotectant in the mouse hippocampus
... The best-known function of the serine protease tissue-type plasminogen activator (tPA) is as a thrombolytic enzyme. However, it is also found in structures of the brain that are highly ...
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Tissue type plasminogen activator increases the binding of glu plasminogen to clots
... Porcine tissue-type plasminogen activator (t-PA) increases the binding of 125I-glu- plasminogen to clots made from human plasma or purified fibrinogen in a time and t-PA concentration ...
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Tissue type plasminogen activator induces opening of the blood brain barrier via the LDL receptor–related protein
... endogenous tissue-type plasminogen activator (tPA) activity in the perivascular tissue following cerebral ischemia induces opening of the BBB via a mechanism that is independent of both ...
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Localization of the binding site of tissue type plasminogen activator to fibrin
... of tissue-type plasminogen ...two-chain tissue-type plasminogen activator, however, destroyed both the binding and catalytic ...of tissue-type ...
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Recombinant plasminogen activator inhibitor 1 reverses the bleeding tendency associated with the combined administration of tissue type plasminogen activator and aspirin in rabbits
... The major side effect of thrombolytic therapy is bleeding; however, the pathogenesis of this potential complication is not well understood. Accordingly, we examined the effects of aspirin and recombinant human ...
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Influence of the fast acting inhibitor of plasminogen activator on in vivo thrombolysis induced by tissue type plasminogen activator in rabbits Interference of tissue derived components
... of plasminogen activator (PA-inhibitor) on thrombolysis was investigated in rabbits with a jugular vein ...human tissue-type plasminogen activator (t-PA) produced similar degrees ...
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alpha Fucose mediated binding and degradation of tissue type plasminogen activator by HepG2 cells
... Binding and degradation of tissue-type plasminogen activator by the human hepatoma cell line HepG2.. Interactions between tissue-type plasminogen activator and extracellular matrix assoc[r] ...
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39 kD protein inhibits tissue type plasminogen activator clearance in vivo
... Tissue-type plasminogen activator (t-PA) is a plasma serine protease that catalyzes the initial and rate-limiting step in the fibrinolytic ...
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Interaction between plasminogen activator inhibitor type 1 (PAI 1) bound to fibrin and either tissue type plasminogen activator (t PA) or urokinase type plasminogen activator (u PA) Binding of t PA/PAI 1 complexes to fibrin mediated by both the finger and the kringle 2 domain of t PA
... complexes of u-PA and PAI-1 dissociate from the fibrin matrix and are encountered in the fluid phase. In contrast, t-PA/PAI-1 complexes remain bound to fibrin. By employing recombinant t-PA deletion-mutant proteins, that ...
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Fibrinolysis regulation by platelets retaining plasminogen and tissue-type plasminogen activator on their surface
... of plasminogen and tissue plasminogen activator, after 60 min of incubation, residual amidolytic activity of plasmin was observed, which may be a result of activation by endogenous activators ...
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Management of Plastic Bronchitis With Topical Tissue-type Plasminogen Activator
... Plastic bronchitis or cast bronchitis is a rare disease of unclear etiology characterized by formation of airway casts that can lead to life- threatening airway obstruction. There is currently limited data regard- ing ...
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Preventing graft restenosis after coronary artery bypass grafting with tissue-type plasminogen activator
... 24. Tardiff BE, Califf RM, Morris D, Bates E, Woodlief LH, Lee KL, Green C, Rutsch W, Betriu A, Aylward PE, Topol EJ. Coronary revascularization surgery after myocardial infarction: impact of bypass surgery on survival ...
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Detection and partial characterization of an inhibitor of plasminogen activator in human platelets
... conclusion is supported by a number of observations. For example, extracts of washed, gel- filtered human platelets contain an inhibitor of similar activity and size, and physiological concentrations of thrombin induce ...
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Extracellular proteolysis in the adult murine brain
... the plasminogen activator/plasmin system in the adult murine central nervous ...system. Tissue-type plasminogen activator is synthesized by neurons of most brain regions, while ...
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Tissue plasminogen activator promotes platelet disaggregation in plasma
... We studied the disaggregation of human platelets by tissue-type plasminogen activator (t- PA). When added to a suspension of human platelets induced to aggregate in plasma with adenosine ...
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Inhibition of angiogenesis by platelets in systemic sclerosis patients
... endothelin-1, tissue type plas- minogen activator, plasminogen activator inhibitor type 1, and platelet-derived growth factor in patients with Raynaud’s phenomenon associated ...
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