TLR-Agonists
TNF α and TLR agonists increase susceptibility to HIV 1 transmission by human Langerhans cells ex vivo
... In contrast to the other TLR agonists, Pam3CSK4 enhanced transmission in all donors tested. Pam3CSK4 is a synthetic tripal- mitoylated lipopeptide that mimics the acetylated amino termi- nus of bacterial ...
14
Effects of TLR agonists on maturation and function of 3 day dendritic cells from AML patients in complete remission
... synthetic TLR agonists could be identified so ...of TLR-agonists was not only based on in vitro evidence of effective DC activation but also upon consideration of GMP availabil- ity for usage ...
14
Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer
... including TLR agonists, are under active investigation in the treatment of solid tumors ...(28–31). TLR agonists initiate innate immune activation in the TME and break immunosup- pression and ...
19
Attenuating regulatory T cell induction by TLR agonists through inhibition of p38 MAPK signaling in dendritic cells enhances their efficacy as vaccine adjuvants and cancer immunotherapeutics
... a TLR agonist as adjuvant, are consistent with these ...of TLR ligands secrete either IFN- ␥ only or IFN- ␥ with IL-10 and neutralization of IFN- ␥ at the initiation of culture allowed expansion of T cells ...
10
Adjuvant effects of different TLR agonists on the induction of allergen specific Th2 responses
... of agonists followed by two OVA aerosol ...the agonists used. All TLR agonists increased allergen-specific IgG2a, and with the exception of poly(I:C), reduced allergen-specific IgE levels in ...
8
The fungal T-2 toxin alters the activation of primary macrophages induced by TLR-agonists resulting in a decrease of the inflammatory response in the pig
... specific TLR-agonists during 16 h at ...with TLR-agonists. TLR-agonists were used with the following concentrations: TLR2-L (HKLM) [10 μg/mL], TLR4-L (LPS) [10 μg/mL], TLR2/6-L ...
11
Overexpression of TLR2 and TLR9 on monocyte subsets of active rheumatoid arthritis patients contributes to enhance responsiveness to TLR agonists
... Little is known about the stimuli capable of triggering signals that result in synovial tissue damage. In addition to cell debris, viral infection has long been speculated to be a potential factor in RA. Several viruses ...
14
Age-Dependent Maturation of Toll-Like Receptor-Mediated Cytokine Responses in Gambian Infants
... 4. TLR agonists induce greater cytokine production in Gambian newborns at 1 month compared to at ...the TLR agonists and cytokine production (pg/mL) in supernatants was measured as described ...
13
Vaccine induced protective immunity to Bordetella pertussis
... three TLR agonists (MALP2, poly (I:C) and CpG) were used in combination as adjuvants for an HIV peptide vaccine, the protective efficacy conferred with the vaccine was significantly enhanced compared with a ...
227
Influence of PapMV nanoparticles on the kinetics of the antibody response to flu vaccine
... through TLR agonists has been shown to increase antigen-spe- cific and neutralizing ...Since TLR agonists induce innate immunity and have been shown to be linked to an increased adaptive ...
9
Bench to bedside review: Natural killer cells in sepsis guilty or not guilty?
... Regarding functional studies, NK cells were shown to have reduced cytotoxic activity in sepsis patients [51,52] and in SIRS patients following thermal and traumatic injury [53,54]. However, a recent review suggested a ...
6
The 3′ CCACCA Sequence of tRNAAla(UGC) Is the Motif That Is Important in Inducing Th1-Like Immune Response, and This Motif Can Be Recognized by Toll-Like Receptor 3
... with TLR agonists by a TLR agonist kit (Invivogen, CA) with human TLR3 agonist poly(I:C), human TLR7 agonist imiquimod, human TLR8 agonist ssRNA40, and human TLR9 agonist ODN2006 were ...
7
Activation of myeloid dendritic cells, effector cells and regulatory T cells in lichen planus
... In PBMCs, the activation of TLRs is primarily thought to affect antigen-presenting cells by inducing an innate immune response that can subsequently activate the adaptive immune system. However, an increasing amount of ...
11
Reactivation of latent HIV 1 in central memory CD4+T cells through TLR 1/2 stimulation
... Thus, TLR-2 can form heterodimers with TLR-1 or TLR-6. TLR-1/2 complexes recognize triacylated lipopeptides whereas TLR-2/6 complexes recognize diacylated lipo- peptides ...addition, ...
15
The Virion Host Shutoff Protein of Herpes Simplex Virus 1 Blocks the Replication-Independent Activation of NF-κB in Dendritic Cells in the Absence of Type I Interferon Signaling
... stocks via quantitative real-time (qRT)-PCR. Further, no virus growth was ob- served during Vero cell plaque assay. Recombinant NDV B1 was generated from the B1 Hitchner avian vaccine strain as previously described (40). ...
11
Toll-Like Receptor Expression and Induction of Type I and Type III Interferons in Primary Airway Epithelial Cells
... of TLR activation and differential IFN production in specific cell populations other than antigen- presenting cells have not yet been fully ...investigated TLR expression and polarization in airway epi- ...
10
Toll-like receptor stimulation increases phagocytosis of Cryptococcus neoformans by microglial cells
... induction of unintended neuronal injury. It may be ne- cessary to design milder strategies for microglial acti- vation in order to increase the infection resistance of the CNS without causing neuronal injury. In conclu- ...
7
Combination therapy targeting toll like receptors 7, 8 and 9 eliminates large established tumors
... There are several mechanisms by which TLR agonists can support the elimination of established tumors. CD28 is a co-stimulatory molecule that enhances the prolifera- tion, cytokine production and survival of ...
10
Toll-Like Receptor 7/8 (TLR7/8) and TLR9 Agonists Cooperate To Enhance HIV-1 Envelope Antibody Responses in Rhesus Macaques
... “hidden” TLR agonists enhances the immunogenicity of FDA-approved vaccines directed against Streptococcus pneumoniae ...trigger TLR pathways during the time of abortive infection that induces ...
11
Identification and Investigation of Conserved Innate Immune Response Genes Between Zebrafish and Humans.
... human TLR orthologs and their adaptor proteins in zebrafish (Jault et ...different TLR agonists: PAM3CSK4 (5 μg/ml), PolyI:C (10μg/ml), and LPS (10 μg/ml), by ...
178