TLR-ligands
Using 3 TLR ligands as a combination adjuvant induces qualitative changes in T cell responses needed for antiviral protection in mice
... TLR ligands are promising candidates for the development of novel vaccine adjuvants that can elicit protec- tive immunity against emerging infectious ...utilizing ligands for 3 TLRs (TLR2/6, TLR3, ...
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Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)
... of TLR ligands. We chose to examine ligands for TLR2, TLR3, TLR4, TLR7/8, and TLR9 based on three ...Finally, ligands for these TLRs induced a reproducible cytokine response in BV-2 ...the ...
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Muramyl dipeptide activation of nucleotide binding oligomerization domain 2 protects mice from experimental colitis
... The mechanisms underlying the susceptibility of individuals with caspase recruitment domain 15 (CARD15) mutations and corresponding abnormalities of nucleotide-binding oligomerization domain 2 (NOD2) protein to Crohn ...
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Effects of budesonide on toll-like receptor expression in alveolar macrophages from smokers with and without COPD
... time point. It cannot be denied that the stimulated effects may take place after a longer stimulation. Despite this, we found significant effects of TLR ligands or endogenous ligand stimulation in the ...
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αvβ3 Integrin Boosts the Innate Immune Response Elicited in Epithelial Cells through Plasma Membrane and Endosomal Toll-Like Receptors
... cells were transfected with small interfering RNA (siRNA) specific to  6 or  8 integrin (Dharmacon) (11), together with TLRs and luciferase plasmids, as above. Cells were exposed to gD ⫺/⫺ HSV or to specific TLR ...
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Antigen-Dependent and -Independent Mechanisms of T and B Cell Hyperactivation during Chronic HIV-1 Infection
... Costimulation by HIV-1 proteins and TLR ligands. The HIV-1 envelope glycoprotein gp120 has been shown to co- stimulate activation of CD4 ⫹ T cells if provided simultaneously with suboptimal TCR stimulation ...
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Toll like receptor 2 controls expansion and function of regulatory T cells
... Proliferation of PAM-expanded Tregs. (A) TLR2 and TCR signals cooperate to increase CD25 expression on Tregs. Tregs were incubated with either PAM, anti-CD3, or a combi- nation of both in IL-2–supplemented medium. CD25 ...
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Characterization of Toll-like receptors in primary lung epithelial cells: strong impact of the TLR3 ligand poly(I:C) on the regulation of Toll-like receptors, adaptor proteins and inflammatory response
... of TLR ligands under well controlled in vitro conditions, we have chosen pri- mary small airway epithelial cells (SAEC) as a model to study the inflammatory response of the lung ...the TLR ...
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Eosinophils in glioblastoma biology
... that TLR-ligand activated dendritic cells or mast cells encourage CD8+ T cell recruitment ...IgE, TLR ligands, IL-4) may propel innate and adaptive immune responses toward tumor ...
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Effect of Ligands to Toll Like Receptors (TLR) 3, 7 and 9 on Mice Infected with Mouse Hepatitis Virus A59
... Mice infected with mouse hepatitis virus A59 (MHV-A59), an enveloped, positive-strand RNA Co- ronavirus, induce hepatitis, thymus involution, IgG2a-restricted hypergammaglobulinaemia, transaminase release and ...
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Original Article Macrophages polarization is mediated by the combination of PRR ligands and distinct inflammatory cytokines
... each TLR ligand was also ...between TLR ligands and NOD ligands were ...single TLR ligand, co-stimulation with NOD li- gand resulted in diverse responses with respect of different ...
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Human Skin Endothelial Cells Can Express All 10 TLR Genes and Respond to Respective Ligands
... for TLR expression by real-time ...of TLR functionality, endothelial cells were challenged with TLR ligands, and after the TLR downstream signaling, MyD88 recruitment as well as early ...
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Molecular mechanisms of autoimmunity triggered by microbial infection
... respective ligands [21,30]. In macrophages and antigen-presenting cells, TLR ligation induces the phagocytic capacity as an important component of pathogen control and antigen-processing ...Upon TLR ...
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Toll like receptors in the endangered Tasmanian devil and devil facial tumour disease
... TLR7 ligands and antigen (Hu et al. 2016), supporting the use of these ligands in a DFTD ...these ligands for human ...these ligands as vaccine adjuvants in the Tasmanian ...with TLR ...
314
Plasmacytoid Dendritic Cells Mediate Synergistic Effects of HIV and Lipopolysaccharide on CD27+ IgD– Memory B Cell Apoptosis
... to TLR ligands alone is not sufficient to result in B cell apoptosis and humoral immunodeficiency, arguing for additional mechanisms of B cell dysfunction in HIV ...
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Development of a Clinical Assay To Evaluate Toll-Like Receptor Function
... of TLR ligand-induced TNF production in pa- tients with NEMO deficiency. TLR ligand-induced TNF pro- duction is likely to be most useful in identifying deficient TLR responses resulting from genetic ...
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Adjuvanting a Simian Immunodeficiency Virus Vaccine with Toll-Like Receptor Ligands Encapsulated in Nanoparticles Induces Persistent Antibody Responses and Enhanced Protection in TRIM5α Restrictive Macaques
... NP-encapsulated TLR ligands and demonstrated their efficacy as vaccine adjuvants in mice ...NP-encapsulated TLR ligands induce robust and persistent antibody responses against SIVmac239 Env ...
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Association between <em>TLR-9</em> polymorphisms and colon cancer susceptibility in Saudi Arabian female patients
... glands that protects the body from foreign invaders. Therefore, an optimized immune system is the key to health and longevity, and the immune system plays a crucial role in preventing cancer. Toll-like receptors (TLRs) ...
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The 3′ CCACCA Sequence of tRNAAla(UGC) Is the Motif That Is Important in Inducing Th1-Like Immune Response, and This Motif Can Be Recognized by Toll-Like Receptor 3
... with TLR agonists by a TLR agonist kit (Invivogen, CA) with human TLR3 agonist poly(I:C), human TLR7 agonist imiquimod, human TLR8 agonist ssRNA40, and human TLR9 agonist ODN2006 were ...
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Regulation of Toll-like receptor 1 and -2 in neonatal mice brains after hypoxia-ischemia
... a TLR-4- and MyD88-dependent pathway ...stimulated TLR-3 and induced an immune response ...studies, TLR-4 has been found to be up-regulated after cerebral ischemia reperfusion [15] and mice lacking ...
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