toll-like receptor
Alternate transcription of the Toll like receptor signaling cascade
... The Irak family of receptor-associated kinases are important mediators of Tlr and IL-1 receptor signaling. Four members of the murine Irak family have been described, and functional studies have ...
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Differential Toll like receptor dependent collagenase expression in chondrocytes
... Cadherin adhesion molecules, structurally typified by their immunoglobulin-like extracellular (cadherin) domains rigidified as an extended chain by interdomain calcium binding, mediate cellular adhesion by binding ...
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Single Nucleotide Polymorphisms of Toll Like Receptor 7 and Toll Like Receptor 9 in Hepatitis C Virus Infection Patients from Central China
... of toll-like receptor 7 (TLR7) (rs179009) and toll-like receptor 9 (TLR9) (rs187084) in hepatitis C virus (HCV) infections in the Han ...
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Posttranslational Modification of HOIP Blocks Toll Like Receptor 4 Mediated Linear Ubiquitin Chain Formation
... alter the intrinsic enzymatic activity of HOIP (see Fig. S1F in the supplemental material). These experiments collectively demon- strate that HOIP is ubiquitinated at the K1056 by multiple types of ubiquitin chains and ...
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Role of polymorphisms of toll like receptor (TLR) 4, TLR9, toll interleukin 1 receptor domain containing adaptor protein (TIRAP) and FCGR2A genes in malaria susceptibility and severity in Burundian children
... of toll-like receptors (TLRs) ...extracellular receptor modules and initiating inflammatory signalling pathways through an intracellular domain ...the Toll- interleukin 1 receptor ...
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Expression of functional toll like receptor 4 in estrogen receptor/progesterone receptor negative breast cancer
... Most studies of TLRs in breast cancer have been per- formed using the ER + cell line MCF-7 and the TN cell line MDA-MB-231 [5]. To our knowledge, a detailed comparison between ER + and TN cell lines or cancers has not ...
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Signal transduction by the lipopolysaccharide receptor, Toll like receptor 4
... the receptor for LPS – Toll-like receptor 4 (TLR4) – but also in a better appre- ciation of the complexity of the signalling pathways activated by ...a receptor complex in response to ...
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Myocardial ischemia/reperfusion injury is mediated by leukocytic toll like receptor 2 and reduced by systemic administration of a novel anti toll like receptor 2 antibody
... Our study also demonstrates that IgG isotype antibody, used as a negative control in our experiments, has several nonsignificant antiinflammatory effects. It does not reduce IS; however, compared with saline treatment, ...
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Association between Toll Like Receptor 4 (Thr399Ile and Asp299Gly), Toll Like Receptor 2 196 174 Deletion Polymorphisms with cryptosporidiosis
... Toll-like receptors (TLRs) 2 and 4 specifically recognize lipopolysaccharide motifs on surfaces of microorganisms. Polymorphims in the TLR genes result in structural variations in the proteins, abnormal ...
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The Toll Like Receptor 4 Antagonist Eritoran Protects Mice from Lethal Filovirus Challenge
... ABSTRACT The 2013-2016 outbreak of Ebola virus (EBOV) in West Africa, which has seen intermittent reemergence since it was officially declared over in February of 2016, has demonstrated the need for the rapid development ...
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Toll and Toll like receptor signalling in development
... via Toll-3 and Toll-9 to trigger, via Dorsal and Dif, the Reaper-induced apoptosis of loser mutant cells, or via Toll-2, -4, -8 and -9 to induce the apoptosis of loser wild-type cells via Sarm, Rel ...
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Modulation of atherosclerosis in mice by Toll like receptor 2
... Epidemiologic evidence has established a relationship between microbial infection and atherosclerosis. Mam- malian TLRs provide clues on the mechanism of this inflammatory cascade. TLR2 has a large ligand repertoire that ...
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Molecular cloning of Peking duck Toll like receptor 3 (duTLR3) gene and its responses to reovirus infection
... The innate immune system is a major contributor to acute inflammation induced by microbial infection or tissue damage. The initial sensing of infection is mediated by in- nate pattern recognition receptors (PRRs), which ...
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Toll like receptor 2 (TLR2) plays a role in controlling cutaneous leishmaniasis in vivo, but does not require activation by parasite lipophosphoglycan
... the receptor to that known for bacterial acylated TLR2 ligands, where the ligand-receptor com- plex has been elucidated in more ...the receptor for its ligand, with TLR2/6 recognising triacylated ...
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Expression profiles of genes involved in TLRs and NLRs signaling pathways of water buffaloes infected with Fasciola gigantica
... TLR1 Toll-like receptor 1 TLR2 Toll-like receptor 2 TLR3 Toll-like receptor 3 TLR4 Toll-like receptor 4 TLR5 Toll-like ...
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Toll like receptor and antimicrobial peptide expression in the bovine endometrium
... Microbial infection of the female genital tract is an impor- tant cause of disease, infertility and mortality in mam- mals, particularly cattle and humans. Bos taurus is a biologically relevant model to study female ...
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Structural complementarity of Toll/interleukin 1 receptor domains in Toll like receptors and the adaptors Mal and MyD88
... The Toll/interleukin 1 receptor (TIR) domain is a re- gion found in the cytoplasmic tails of members of the Toll-like receptor/interleukin-1 receptor ...two ...
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Original Article Gallic acid inhibits LPS induced hypertrophic scar inflammation via toll-like receptor 4/nuclear factor-κB/peroxisome proliferator-activated receptor γ signaling
... tential target for treatment of inflammatory dis- eases, such as ulcerative colitis, atherosclero- sis, and rheumatoid arthritis. Furthermore, naturally occurring or synthetic ligands of PPARγ have been shown to inhibit ...
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Interaction between Ebola Virus Glycoprotein and Host Toll-Like Receptor 4 Leads to Induction of Proinflammatory Cytokines and SOCS1
... TAM receptor signaling was shown in a separate report to induce expression of SOCS1, leading to subsequent negative regulation of surface-expressed TLR receptors and TLR-induced cytokine-receptor cascades ...
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Preferential Activation of Toll-Like Receptor Nine by CD46-Utilizing Adenoviruses
... CD46-utilizing Ads preferentially induce TLR9 signaling. In the studies described above, Ad-induced IFN production was analyzed in cells that were permissive only for CD46-utilizing Ad serotypes, and therefore it was not ...
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