Toll like receptor
Toll-like receptor 2 and type 2 diabetes
... AP-1, activator protein 1; CRP, C-reactive protein; DAMPs, damage-associated molecular patterns; IRF, interferon regulatory factor; JAK-STAT, Janus kinase-signal transducer and activator of transcription; LDL, ...
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MicroRNAs and Toll-like Receptor/Interleukin-1 Receptor Signaling
... disorders like rheumatoid arthritis, systemic lupus erthematosus, experimental autoimmune encephalomyelitis, and inflammatory ...on toll-like receptor (TLRs) and interleukin-1 β (IL-1 β ) ...
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Toll Like Receptor 3/TRIF Dependent IL 12p70 Secretion Mediated by Streptococcus pneumoniae RNA and Its Priming by Influenza A Virus Coinfection in Human Dendritic Cells
... ABSTRACT A functional immune response is crucial to prevent and limit infections with Streptococcus pneumoniae. Dendritic cells (DCs) play a central role in orchestrating the adaptive and innate immune responses by ...
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Single Nucleotide Polymorphisms of Toll Like Receptor 7 and Toll Like Receptor 9 in Hepatitis C Virus Infection Patients from Central China
... of toll-like receptor 7 (TLR7) (rs179009) and toll-like receptor 9 (TLR9) (rs187084) in hepatitis C virus (HCV) infections in the Han ...
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Toll like receptor downstream signaling
... Drosophila, Toll was initially identified as an essential protein for the determination of dorsoventral polarity during early ...mutant Toll gene are highly susceptible to fungal infection because of a ...
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Expression and activation of toll-like receptor 3 and toll-like receptor 4 on human corneal epithelial and conjunctival fibroblasts
... Interestingly, activation of HCE TLR3 and TLR4 by poly I:C and LPS, while stimulating secretion of pro- inflammatory cytokines and the up-regulation of their respective genes, was found to decrease TLRs surface ex- ...
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Genipin Attenuates Sepsis by Inhibiting Toll-Like Receptor Signaling
... failure. Toll-like receptor (TLR) signaling is crucial for induction of hyperinflammatory responses and tissue injury during ...the Toll/interleukin-1 receptor domain-containing adaptor ...
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Emerging role of Toll-like receptor 4 in hepatocellular carcinoma
... Abstract: Toll-like receptor (TLR) signaling has been implicated in inflammatory-related cancers. The upregulation of TLR signaling in hepatocellular carcinoma (HCC) suggests that it may play an ...
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The Toll Like Receptor 4 Antagonist Eritoran Protects Mice from Lethal Filovirus Challenge
... ABSTRACT The 2013-2016 outbreak of Ebola virus (EBOV) in West Africa, which has seen intermittent reemergence since it was officially declared over in February of 2016, has demonstrated the need for the rapid development ...
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Functional Consequences of Toll-like Receptor 4 Polymorphisms
... Toll-like receptor 4 (TLR4) is an important pathogen recognition receptor that recognizes mainly lipopolysaccharide (LPS) of Gram- negative bacteria, but also structures from fungal and ...
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Association between Toll Like Receptor 4 (Thr399Ile and Asp299Gly), Toll Like Receptor 2 196 174 Deletion Polymorphisms with cryptosporidiosis
... The Toll-Like Receptor 2 (TLR2)-196 to -174 Del/Ins Polymorphism Affects Viral Loads and Susceptibility to Hepatocellular Car- cinoma in Chronic Hepatitis ...
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Structural characterisation of Toll-like receptor 1 (TLR1) and Toll-like receptor 6 (TLR6) in elephant and harbor seals
... (2016) 'Structural characterisation of Toll-like receptor 1 (TLR1) and Toll-like receptor 6 (TLR6) in elephant and harbor seals', Veterinary Immunology and.. Immunopathology, 169, 10-14[r] ...
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A Fast Procedure for the Detection of Defects in Toll-like Receptor Signaling
... in Toll-like receptor signaling are recently described pri- mary immunodeficiencies that predispose affected children to life-threatening ...interleukin-1 receptor-associated kinase-4 ...
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Signal transduction by the lipopolysaccharide receptor, Toll like receptor 4
... the receptor for LPS – Toll-like receptor 4 (TLR4) – but also in a better appre- ciation of the complexity of the signalling pathways activated by ...a receptor complex in response to ...
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Chemoproteomics reveals Toll-like receptor fatty acylation
... Bioinformatic classification of alk-16-labeled proteins commonly identified in both MEFs and DC2.4 cells We identified 121 alk-16-labeled proteins that were com- mon to both DC2.4 cells and MEFs (listed in Additional ...
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Toll-like receptor cascade and gene polymorphism in host–pathogen interaction in Lyme disease
... Abstract: Lyme disease (LD) risk occurs in North America and Europe where the tick vectors of the causal agent Borrelia burgdorferi sensu lato are found. It is associated with local and systemic manifestations, and has ...
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Modulation of atherosclerosis in mice by Toll like receptor 2
... Epidemiologic evidence has established a relationship between microbial infection and atherosclerosis. Mam- malian TLRs provide clues on the mechanism of this inflammatory cascade. TLR2 has a large ligand repertoire that ...
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Toll like receptor polymorphisms in malaria endemic populations
... as Toll-Interleukin-1 Receptor domain-containing Adaptor Protein, TIRAP) is a down- stream adaptor protein common to both the TLR2 and TLR4 signaling pathways ...
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Are Toll-like receptor gene polymorphisms associated with prostate cancer?
... Toll-like receptors (TLRs) constitute a family of receptors that recognize pathogen- associated and damage-associated molecular patterns, consequently playing a key role in innate and adaptive immune ...
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Differential Toll like receptor dependent collagenase expression in chondrocytes
... Cadherin adhesion molecules, structurally typified by their immunoglobulin-like extracellular (cadherin) domains rigidified as an extended chain by interdomain calcium binding, mediate cellular adhesion by binding ...
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