Toll-like receptor 4 polymorphism
Association of Toll-like receptor 4 polymorphism with age-dependent systolic blood pressure increase in patients with coronary artery disease
... SBP starting from the age of 70 years. Other studies in- vestigating genetic variants which influence on blood pressure did neither detect an association with TLR4 [24] nor the SNP rs4986790 [25]. This is explained by ...
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Association of coronary artery disease with toll-like receptor 4 genetic variants: A meta-analysis
... ature search was implemented in the online databases Web of Science, Embase, Scopus, PubMed, and Wanfang Med Online to search for case-control studies evaluating the relationship of the TLR4 polymorphisms rs4986790 and ...
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Toll-Like Receptor 4 Gene Polymorphism C1196T in Polish Women with Postmenopausal Osteoporosis – Preliminary Investigation
... and bone mineral density and osteoporotic frac- ture incidence in Polish postmenopausal women with osteoporosis. In 2004, Johnson et al. showed the association of C1196T and A896G polymor- phisms of the TLR4 gene with ...
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Association of Toll-like receptor 2, 4, and 9 gene polymorphism with high altitude induced thrombosis patients in Indian population
... diseases like atherosclerosis, thrombosis, congestive heart failure and cardiac dysfunction in sepsis ...TLR polymorphism and their susceptibility to cardiovascular diseases is ...2, 4 and 9 genes in ...
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Functional Consequences of Toll-like Receptor 4 Polymorphisms
... Africa migration approximately 55,000 to 60,000 years ago. Nowadays, human populations from Africa have a 10- to 20- fold higher frequency of the Asp299Gly haplotype than those from the other con- tinents. In contrast, ...
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Toll like receptor polymorphisms and cerebral malaria: TLR2 Δ22 polymorphism is associated with protection from cerebral malaria in a case control study
... a receptor for parasite derived GPI, TLR2 is likely involved in dis- ease pathogenesis [3], however, a previous study exam- ining single nucleotide polymorphisms (SNPs) within TLR2 could not detect an association ...
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Association between toll-like receptors 9 (TLR9) gene polymorphism and risk of pulmonary tuberculosis: meta-analysis
... recognition receptor in leukocytes endo- some, especially in B cells, plasmacytoid dendritic cells (pDCs) and ...The Toll- IL-1 receptor (TIR) domain of TLR9 in intracellular space associates with ...
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Association between Toll Like Receptor 4 (Thr399Ile and Asp299Gly), Toll Like Receptor 2 196 174 Deletion Polymorphisms with cryptosporidiosis
... TLR 4 Thr_399_Ile and TLR 4 Asp_299_Gly and TLR2 196 to 174 del polymorphisms, using previously described primers and conditions [12] ...TLR 4 Thr_399_Ile and TLR 4 Asp_299_Gly ...- 4% ...
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The regulatory toll like receptor 4 genetic polymorphism rs11536889 is associated with renal, coagulation and hepatic organ failure in sepsis patients
... gram-negative sepsis [3]. Excessive amounts of gut- derived LPS released during intestinal hypo-perfusion have also been implicated in sepsis caused by gram- positive and fungal infections [4,5]. LPS signaling is initi- ...
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Phylogenetic variation and polymorphism at the Toll like receptor 4 locus (TLR4)
... Although LPS was once thought to exert its effects through intercalation into biological membranes, or to bind to many different receptors on the cell surface, it has been clear for nearly three decades that there is, in ...
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Candidate role for TLR3 L412F in disease progression in Idiopathic Pulmonary Fibrosis (IPF) during bacterial and viral infection
... and 4 respectively is attenuated in Leu/Phe IPF ...2, 4, 5, 6, and 9 recognise specific bacterial PAMPs, while TLRs 3, 7, 8 and 9 recognise viral ...
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Toll-like receptor 2 plays a critical role in pathogenesis of acne vulgaris
... glycoprotein receptor, composed with an extracellular domain (ECD), a single transmembrane domain, and an intracellular Toll/interleu- kin-1 receptor (TIR) domain (Jin and Lee 2008; Akira and Takeda ...
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Structural characterisation of Toll-like receptor 1 (TLR1) and Toll-like receptor 6 (TLR6) in elephant and harbor seals
... (2016) 'Structural characterisation of Toll-like receptor 1 (TLR1) and Toll-like receptor 6 (TLR6) in elephant and harbor seals', Veterinary Immunology and.. Immunopathology, 169, 10-14[r] ...
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Expression of functional toll like receptor 4 in estrogen receptor/progesterone receptor negative breast cancer
... Additional file 2: Figure S1. A Annexin V staining of MDA-MB-231 cells using flow cytometry to investigate apoptosis of MDA-MB-231 cells transfected with negative control (nc) siRNA, or siRNA directed against TLR2 mRNA ...
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Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium
... ventralizing Toll mutants were formed in Drosophila by removal of the extracellular LRR and cysteine-enriched flanking sequences, Medzhitov et ...active Toll homologue consisting of a CD4 extracellular ...
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Toll like receptor 9 (TLR9) polymorphism associated with symptomatic malaria: a cohort study
... In this cohort study, the intronic polymorphism rs352139 (G + 1174A) GG genotype was significantly associated with increased risk for symptomatic malaria and high parasitaemia. Previous functional study has ...
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Toll and Toll like receptor signalling in development
... via Toll-3 and Toll-9 to trigger, via Dorsal and Dif, the Reaper-induced apoptosis of loser mutant cells, or via Toll-2, -4, -8 and -9 to induce the apoptosis of loser wild-type cells via ...
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Toll-like receptor 4 deficiency: Smaller infarcts, but nogain in function
... Innate immunity is involved in myocardial ischemia/ reperfusion (MI/R) injury, specifically through activation of TLR4, which was originally proposed to solely recog- nize lipopolysaccharide (LPS) [3]. Other cell ...
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Toll-like receptor cascade and gene polymorphism in host–pathogen interaction in Lyme disease
... by Toll-like receptors ...nucleotide polymorphism-related functional alterations are postulated to be linked to disease development and posttreatment persistent ...
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Lipopolysaccharide and toll-like receptor 4 in dogs with congenital portosystemic shunts
... degree of portal blood flow and significantly increases following partial CPSS. 495[r] ...
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