Toll-like receptor agonist
Combination of the toll like receptor agonist and α-Galactosylceramide as an efficient adjuvant for cancer vaccine
... [11–13]. Toll-like receptors (TLRs) play an important role in the innate recognition of pathogen- associated molecular patterns (PAMPs) and initiation of immune responses in dendritic cells (DCs) ...single ...
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Dendritic cell vaccination with a toll-like receptor agonist derived from mycobacteria enhances anti-tumor immunity
... of toll-like receptor (TLR) ligand agonists as adjuvants in an anti-viral vaccine significantly enhanced the functional avidity of the T cells, rather than increasing their numbers, markedly ...
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Biomarkers can predict potential clinical responders to DIMS0150 a toll-like receptor 9 agonist in ulcerative colitis patients
... DIMS0150 is a fully synthetic oligodeoxynucleotide and its mode of action is thought to be triggered by the interaction with TLR9, which stimulates the production of specific chemokines and cytokines from mucosal im- ...
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Synthetic Toll-Like Receptor 4 Agonist Enhances Vaccine Efficacy in an Experimental Model of Toxic Shock Syndrome
... TLR4 agonist E6020 is a synthetic mimic of LPS that has many features in common with the naturally produced TLR4 agonist yet may cir- cumvent the safety concerns associated with LPS ...TLR4 agonist ...
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The FomA Porin from Fusobacterium nucleatum Is a Toll-Like Receptor 2 Agonist with Immune Adjuvant Activity
... Many bacterial components selectively activate immune and nonhematopoietic target cells via Toll-like receptor (TLR) signal- ing; modulation of such host responses defines the immune adjuvant ...
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An Intranasally Delivered Toll-Like Receptor 7 Agonist Elicits Robust Systemic and Mucosal Responses to Norwalk Virus-Like Particles
... TLR agonist used as an NV VLP vaccine adjuvant in this study, has been previously shown to enhance the maturation of antigen-pre- senting cells and the secretion of proinflammatory Th1-like cytokines, ...
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Toll Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection
... TLR3 agonist poly(I:C) and the TLR4 agonist lipopolysaccharide (LPS) are protective against SARS-CoV infection in mice when administered prophylactically, although poly(I:C) is more effective than LPS ...
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FSL 1, a bacterial derived toll like receptor 2/6 agonist, enhances resistance to experimental HSV 2 infection
... TLR2/6 agonist FSL-1 is capable of significantly increasing resistance to HSV-2 infection in mice through induction of a specific cytokine response ...TLR agonist interventions and will aid in improving the ...
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Flagellin A Toll-Like Receptor 5 Agonist as an Adjuvant in Chicken Vaccines
... Chicken raised under commercial conditions are vulnerable to environmental exposure to a number of pathogens. Therefore, regular vaccination of the flock is an absolute requirement to prevent the occurrence of infectious ...
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Toll Like Receptor 3/TRIF Dependent IL 12p70 Secretion Mediated by Streptococcus pneumoniae RNA and Its Priming by Influenza A Virus Coinfection in Human Dendritic Cells
... tigate whether this cytokine boost is caused by an IAV-triggered upregulation of TLR3 expression. We found an increase in TLR3 expression, which peaked at 8 h post-IAV infection, both in IAV singly infected DCs as well ...
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High-dose irradiation in combination with toll-like receptor 9 agonist CpG oligodeoxynucleotide 7909 downregulates PD-L1 expression via the NF-κB signaling pathway in non-small cell lung cancer cells
... Objectives: Irradiation resistance appears as local recurrence and distant metastasis in advanced stages of non-small cell lung cancer (NSCLC). High-dose irradiation combined with immunotherapy improved overall survival ...
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Poly (I:C), an agonist of toll like receptor 3, inhibits replication of the Chikungunya virus in BEAS 2B cells
... CHIKV transmission is rapid and extensive; however, humans are not defenseless, and in fact, CHIKV is effi- ciently cleared within 4–7 days after infection in vivo [20-22]. As a typical adaptive immune response, such as ...
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Promising Role of Toll-Like Receptor 8 Agonist in Concert with Prostratin for Activation of Silent HIV
... (PKC) agonist prostratin, with a Toll-like receptor 8 (TLR8) agonist, resulted in greater reversion of HIV latency than any sin- gle ...TLR8 agonist in reversing HIV latency when ...
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Molecular cloning of Peking duck Toll like receptor 3 (duTLR3) gene and its responses to reovirus infection
... molecules that are formed during viral genome replica- tion or transcription and localizes exclusively in intracel- lular vesicles such as endosomes and the endoplasmic reticulum, in which viruses undergo un-coating ...
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Roflumilast improves corticosteroid resistance COPD bronchial epithelial cells stimulated with toll like receptor 3 agonist
... Figure 4 Roflumilast N-oxide inhibited IL-8 release in human bronchial epithelial cells and demonstrated additive anti-inflammatory properties in corticosteroid resistance conditions. Human bronchial epithelial cells ...
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Perspectives for immunotherapy: which applications might achieve an HIV functional cure?
... In particular, in order to achieve a more efficient HIV cure, immunotherapy strategies could be combined with new types of drug such as the toll-like receptor 7 TLR7 agonist, which can i[r] ...
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Differential toll-like receptor 3 (TLR3) expression and apoptotic response to TLR3 agonist in human neuroblastoma cells
... TLR3 agonist, the NB cells (seeded at 3 × 10 4 cells/cm 2 in 60-mm dishes) were treated with Poly(I:C) (Invivogen; San Diego, CA) in DMEM with 10% FBS at indicated doses for 24 ...
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Enhancement of Serum and Mucosal Immune Responses to a Haemophilus influenzae Type B Vaccine by Intranasal Delivery
... a Toll-like receptor 4 (TLR4) agonist as an adjuvant significantly increased the levels of IgA specific for the PRP capsule antigen in blood serum, saliva, and mucosal secretion ...TLR4 ...
7
Expression and activation of toll-like receptor 3 and toll-like receptor 4 on human corneal epithelial and conjunctival fibroblasts
... Interestingly, activation of HCE TLR3 and TLR4 by poly I:C and LPS, while stimulating secretion of pro- inflammatory cytokines and the up-regulation of their respective genes, was found to decrease TLRs surface ex- ...
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Cigarette smoke increases TLR4 and TLR9 expression and induces cytokine production from CD8+T cells in chronic obstructive pulmonary disease
... Toll-like receptors (TLR), a key component of the innate immune system, sense foreign microbes via pathogen-associated molecular patterns. Although lar- gely found on innate immune and structural cells ...
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