Toll-like receptor agonists
Toll-Like Receptor Agonists Synergistically Increase Proliferation and Activation of B Cells by Epstein-Barr Virus
... of Toll-like receptor agonists on the activation and growth transformation of human B cells by EBV, focusing on the early days after ...that agonists for several TLRs enhanced the ...
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Definitive activation of endogenous antitumor immunity by repetitive cycles of cyclophosphamide with interspersed Toll- like receptor agonists
... Many cancers both evoke and subvert endogenous anti-tumor immunity. However, immunosuppression can be therapeutically reversed in subsets of cancer patients by treatments such as checkpoint inhibitors or ...
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Activin A increases phagocytosis of Escherichia coli K1 by primary murine microglial cells activated by toll-like receptor agonists
... A receptor type I; Act-RII: Activin A receptor type II; ANOVA: Analysis of variance; BSA: Bovine serum albumin; CFU: Colony-forming units; CNS: Central nervous system; CpG: Cytosine- guanosine motifs; cRBC: ...
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Analysis of Apoptosis of Memory T Cells and Dendritic Cells during the Early Stages of Viral Infection or Exposure to Toll-Like Receptor Agonists
... We therefore tested the hypothesis that aged mice, which have less IFN-I-induced attrition than young mice, would mount a greater cross-reactive response than would young mice. Young and aged naïve (Fig. 8A) or ...
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CD8+ T Cell Immunodominance in Lymphocytic Choriomeningitis Virus Infection Is Modified in the Presence of Toll-Like Receptor Agonists
... During infections, pAPCs employ various receptors to sense pathogen-associated molecular patterns, e.g., Toll-like recep- tors (TLRs) (6). The interaction of TLRs with their TLR ligands (TLR-L) affects the ...
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Toll-like receptor agonists partially restore the production of pro-inflammatory cytokines and type I interferon in Sézary syndrome
... Although IFN-α secretion levels in SS were restored with the TLR9 agonist (CpGA), this positive regulation was not observed for other cytokines, in direct contrast to the broad activity of CL097. These different effects ...
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A multipeptide vaccine plus toll-like receptor agonists LPS or polyICLC in combination with incomplete Freund’s adjuvant in melanoma patients
... tested agonists for both TLR3 and TLR4. TLR4 agonists have also been studied as vaccine adju- vants, but the classic TLR4 agonist, LPS, has long been considered too toxic for human ...
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Epigallocatechin-3-gallate suppresses proinflammatory cytokines and chemokines induced by Toll-like receptor 9 agonists in prostate cancer cells
... TLR9 agonists like CpG-ODN induce proinflammatory cytokines in DU145, PC3, and LnCap prostate cancer ...TLR9 agonists induce proinflam- matory cytokines and MMPs, and that EGCG suppresses ...
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PPAR Gamma agonists regulate tobacco smoke-induced toll like receptor 4 expression in alveolar macrophages
... of Toll-like receptors (TLRs) can trig- ger AMs to produce inflammatory mediators ...PPARγ agonists in preventing chronic airway inflammation and impairing the AM response to ...PPARγ agonists ...
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Toll-like Receptor 2 and 4 (TLR2 and TLR4) Agonists Differentially Regulate Secretory Interleukin-1 Receptor Antagonist Gene Expression in Macrophages
... Interleukin-1 is one of the most highly inflammatory cyto- kines produced by monocytes/macrophages in response to stim- ulation with LPS. The discovery of a naturally occurring IL-1 receptor antagonist (IL-1Ra) ...
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Accessory-Cell-Mediated Activation of Porcine NK Cells by Toll-Like Receptor 7 (TLR7) and TLR8 Agonists
... TLR agonists may induce the expression of ligands on DCs that interact with receptors on NK cells, enabling the latter to become activated in a cell-cell-dependent ...
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Toll-Like Receptor 7 (TLR-7) and TLR-9 Agonists Improve Hepatitis C Virus Replication and Infectivity Inhibition by Plasmacytoid Dendritic Cells
... anti-TRAIL receptor 1 (DR4), peridinin chlorophyll protein (PerCP) anti-TRAIL receptor 2 (DR5) (R&D Systems), fluorescein isothiocyanate (FITC)-conjugated anti-annexin V (BD Biosciences), and ...
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Modulation of atherosclerosis in mice by Toll like receptor 2
... Epidemiologic evidence has established a relationship between microbial infection and atherosclerosis. Mammalian TLRs provide clues on the mechanism of this inflammatory cascade. TLR2 has a large ligand repertoire that ...
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Toll Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection
... IMPORTANCE Toll-like receptors are a family of sensor proteins that enable the immune system to differentiate between “self” and ...“non-self.” Agonists and antagonists of TLRs have been proposed to ...
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Toll-like receptor 2 and type 2 diabetes
... TLR2 recognizes its ligands in both homodimer and heterodimer (with TLR1 or 6) forms [34]. In its homodimer form, it recognizes lipopolysacharide (LPS), porins, lipoprotein, lipoteichoic acid, bacterial peptidoglycan, ...
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Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium
... driving Toll expression and signaling under these conditions? Unlike the rapid clarification to date of the intracellu- lar signaling pathways used by Toll, the ligand for Toll activation in ...
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RIG-I-Like Receptor and Toll-Like Receptor Signaling Pathways Cause Aberrant Production of Inflammatory Cytokines/Chemokines in a Severe Fever with Thrombocytopenia Syndrome Virus Infection Mouse Model
... (IFN-I) receptor 1-deficient (IFNAR1 ⫺/⫺ ) mice have been established as nonlethal and lethal models of SFTSV in- fection, ...(RIG-I)-like receptor (RLR) and Toll-like recep- tor (TLR) ...
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Arg753gln and Arg677 Trp Polymorphisms of Toll-Like Receptor 2 In Acute Apical Abscess
... in toll/IL-1 receptor (TIR) signaling domain of TLR-2, and lead to reduced signaling activity of the ...this receptor may attenuate the inflammatory immune responses against causative microorganisms ...
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Signal transduction by the lipopolysaccharide receptor, Toll like receptor 4
... LPS receptor complex by initially binding LPS and then forming a ternary complex with CD14, thus en- abling LPS to be transferred to the LPS receptor complex composed of Toll-like ...
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Chemoproteomics reveals Toll-like receptor fatty acylation
... lipomannan, which are microbe-based ligands specifically detected by TLR2 (Figure 3B). Since prolonged exposure to 2-BP can result in off-target effects and cellular toxicity [55,56], we also employed Sendai virus, a ...
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