Topoisomerase II
Topoisomerase II Inhibitors Induce DNA Damage Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion
... Doxorubicin and daunorubicin induce IFN by an ATM-dependent mechanism. Doxorubicin has pleiotropic effects on cells. Among its activities, it is a topoisomerase II poison that intercalates into DNA, ...
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In silico identification and evaluation of hits for the inhibition of topoisomerase-ii enzyme via structure based pharmacophore mapping and virtual screening
... cancer topoisomerase II enzyme including rational discovery of potential agents based on non- competitive binding, structure based virtual screening, ligand based virtual screening, synthesizing rationally ...
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Polyomavirus minichromosomes: associated DNA topoisomerase II and DNA ligase activities.
... When DNA topoisomerase II activity arbitrary units based on the appearance of completely unknotted bacteriophage P4 DNA molecules was computed relative to the total number of polyomaviru[r] ...
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The role of NF Y in the transcriptional regulation of human topoisomerase II¯ : a thesis presented to Massey University in partial fulfilment of the requirement for the degree of Master of Science in Biochemistry
... Resistance to various topoisomerase targeting drugs has been observed with factors as candidates for the production of resistant cancer cells with respect to topoisomerase II targeted dr[r] ...
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Hypersensitive Inhibition of the Proliferation of Cells with Mutated DNA Repair Related Genes by the Catalytic Topoisomerase II Inhibitor 20 O IngenolEZ
... Topoisomerase II (topo II) is essential for the survival of proliferating cells, and it is involved in recombination, chromosome condensation, and decatenation of sister chromatids before anaphase of ...
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The ATP dependent chromatin remodelling enzyme Uls1 prevents Topoisomerase II poisoning
... Topoisomerase II (Top2) is an essential enzyme that decatenates DNA via a transient Top2-DNA cova- lent intermediate. This intermediate can be stabilized by a class of drugs termed Top2 poisons, resulting ...
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Topoisomerase II cleavage of herpes simplex virus type 1 DNA in vivo is replication dependent.
... Figure 8 summarizes the cleavages mapped in vivo in this DISCUSSION Topoisomerase II consensus sequences are distributed throughout the HSV-1 genome, and some of these sites are recogniz[r] ...
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Assessment of drug induced genotoxicity in mammalian cells and the contribution of topoisomerase II inhibition
... or topoisomerase II ...research, topoisomerase II inhibition is a particularly interesting genotoxic mechanism, as the enzyme is used as a target for both oncology and anti-infective ...some ...
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cGAS/STING axis mediates a topoisomerase II inhibitor–induced tumor immunogenicity
... DNA topoisomerase II inhibitor, could induce high-mobility group box 1 (HMGB1) release and type I IFN signaling in tumor cells and that teniposide-treated tumor cells could activate antitumor T cell ...
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SIZ1/SIZ2 Control of Chromosome Transmission Fidelity Is Mediated by the Sumoylation of Topoisomerase II
... The results showing that the simultaneous loss of Siz1p and Siz2p activity is epistatic to the top2 SNM al- leles and yields an unmodified Top2p suggest that the role of SUMO E3 in chromosome segregation could be limited ...
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The significance of Epstein Barr Virus (EBV) & DNA Topoisomerase II alpha (DNA-Topo II alpha) immunoreactivity in normal oral mucosa, Oral Epithelial Dysplasia (OED) and Oral Squamous Cell Carcinoma (OSCC)
... anti-human Topoisomerase II α protein (DAKO, clone: Ki-S1, isotype: IgG2a) were ...Topo II α antibody provided in liquid form as purified IgG diluted in ...
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Topoisomerase II and other DNA-delay and DNA-arrest mutations impair bacteriophage T4 DNA packaging in vivo and in vitro.
... Temperature shift and in vitro packaging experiments with the am39 mutant indicated that packaging of normal DNA occurs in the absence of topoisomerase II function, yet in vivo and in vi[r] ...
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Identification within the simian virus 40 genome of a chromosomal loop attachment site that contains topoisomerase II cleavage sites.
... This region contains topoisomerase II cleavage sites, exhibits sequence similarity with cellular MARs, and recognizes the same evolutionarily conserved, abundant nuclear binding sites se[r] ...
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Maternal topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of zebrafish top2a / mutants
... topoisomerases II paralogues are also important as targets of anti-cancer ...blocks topoisomerase II-mediated ATP hydrolysis which is required to regenerate its active enzymatic form ...a ...
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The role of NF Y in the transcriptional regulation of human topoisomerase II¯ : a thesis presented to Massey University in partial fulfilment of the requirement for the degree of Master of Science in Biochemistry
... Resistance to various topoisomerase targeting drugs has been observed with factors as candidates for the production of resistant cancer cells with respect to topoisomerase II targeted dr[r] ...
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Association between the p170 form of human topoisomerase II and progeny viral DNA in cells infected with herpes simplex virus type 1.
... In the present study, we show that topoisomerase II activity persists in HSV-1-infected cells and that both forms are present throughout the infection; however, only p170 topoisomerase I[r] ...
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Human cytomegalovirus induces expression of cellular topoisomerase II.
... By measuring the abundance of topoisomerase II RNA and protein in infected cells at various times after infection, we hoped to determine whether HCMV might fulfill its need for topoisome[r] ...
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Prognostic Values of Filamin-A Status for Topoisomerase II Poison Chemotherapy
... Topo II poisons, including etoposide and ...Topo II poisons than those with defective filamin-A, and filamin-A proficient xenograft mel- anomas have better response to etoposide treatment than the filamin-A ...
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Genetic analysis of the gyrase A-like domain of DNA topoisomerase II of Saccharomyces cerevisiae.
... used tetrad analysis to group the extragenic suppres- sor mutations. Tetrad analysis showed that seven of the 16 tos mutations fell into one linkage group, which we refer to[r] ...
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Topoisomerase II beta interacts with cohesin and CTCF at topological domain borders
... polymerase II as well as topoisomerase I and II proteins ...ase II and TOP2 ...polymerase II inhibitor alpha-amanitin; ...by topoisomerase inhibition when transcrip- tion is ...
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