Topoisomerase IIα
c erbB2 and topoisomerase IIα protein expression independently predict poor survival in primary human breast cancer: a retrospective study
... ase IIα protein ...as topoisomerase II α located near to the c-erbB2 locus on chromosome 17 ...of topoisomerase II α gene alterations (amplification or deletion) was exclusively seen in c- ...
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Cu(II) Benzoylpyridine Thiosemicarbazone Complexes: Inhibition of Human Topoisomerase IIα and Activity against Breast Cancer Cells
... In a fortuitous coincidence, the copper complexes of α-(N)-heterocyclic thiosemicarbazones appear to have high antineoplastic activity through an entirely different mechanism [19]-[21]. Cu(II) acetylpyridine-thiosemi- ...
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Original Article Topoisomerase IIα and BRCA1 expression as predictive factors for anthracycline-based adjuvant chemotherapy response and prognosis in triple-negative breast cancers
... Abstract: Triple-negative breast cancer (TNBC) is an aggressive histologically-defined cancer with a poor outcome for patients because there is a lack of targeted treatments. Anthracycline has an anti-tumor effect ...
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Topoisomerase IIα promotes activation of RNA polymerase I transcription by facilitating pre-initiation complex formation.
... De novo functional PIC formation is also required for activation of Pol I transcription at the majority of rDNA promoters upon refeeding of serum-starved cells, and we discovered that To[r] ...
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Topoisomerase IIα promotes activation of RNA polymerase I transcription by facilitating pre initiation complex formation
... De novo functional PIC formation is also required for activation of Pol I transcription at the majority of rDNA promoters upon refeeding of serum-starved cells, and we discovered that To[r] ...
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Geminin overexpression prevents the completion of topoisomerase IIα chromosome decatenation, leading to aneuploidy in human mammary epithelial cells
... The facts that geminin overexpression decreased Cdc7 expression, that Cdc7 silencing restored stalled chromosome decatenation and/or segregation that is, chromosome bridges [72] in the g[r] ...
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Cu(II) Propionyl Thiazole Thiosemicarbazone Complexes: Crystal Structure, Inhibition of Human Topoisomerase IIα, and Activity against Breast Cancer Cells
... This work expands upon that type research by introducing a previously unknown series of α-N-heterocyclic thiosemicarbazones ligands based on a 2-propionyl-thiazole backbone, and their Cu[r] ...
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Evaluation of the proliferation markers Ki-67/MIB-1, mitosin, survivin, pHH3, and DNA topoisomerase IIα in human anaplastic astrocytomas - an immunohistochemical study
... In conclusion, immunohistochemical determination of proliferative activity in anaplastic astrocytomas using antibodies against Ki-67 antigen, survivin, mitosin, pHH3 and DNA topoisomeras[r] ...
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An investigation into the regulation of the topoisomerase IIα promoter in breast cancer cells exposed to doxorubicin : a thesis presented to Massey University in partial fulfillment of the requirement for the degree of Doctor of Philosophy in Biochemistry
... Topoisomerases are ubiquitous enzymes involved in the manipulation of DNA topology. An understanding of the mechanism of action as well as the regulation of topoisomerases (topo) is crucial, not only to understand DNA ...
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Prognostication of prostate cancer based on TOP2A protein and gene assessment: TOP2A in prostate cancer
... Increased TOP2A is a common, though not specific, oc- currence in malignant cells [19]. According to O’Connor et al. [19], there are several mechanisms to explain this upregulation in these cells. First, both pRB and p53 ...
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... regulate topoisomerase IIα expression, in in-vitro studies they found that p53 has the ability to regulate topoisomerase IIα transcription, by interacting with topoisomerase promoter ...
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Key words
... the topoisomerase I molecule (clone 1D6, Novocastra), and anti-topoisomerase IIα, which reacts with human topoisomerase II alfa (clone 3F6, ...
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A role for topoisomerase II alpha in chromosome damage in human cell lines
... anti-topoisomerase IIα rabbit polyclonal antibody at a dilution of 1:500 (Abcam, Cambridge, UK) in fresh 5% BSA/PBST in a moisture chamber for 1 hour at room temperature before being washed as ...
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Kampik, Theresa (2008): Prognostische Relevanz disseminierter Tumorzellen im Knochenmark sowie tumorbiologischer Faktoren bei 265 Patientinnen mit Mammakarzinom. Dissertation, LMU München: Medizinische Fakultät
... war Topoisomerase IIα nur in zwei Studien von Rudolph et ...von Topoisomerase IIα als prognostischen Faktor zu ...von Topoisomerase IIα scheint ihr prädiktiver Wert zu ...sein. ...
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Top2a identifies and provides epigenetic rationale for novel combination therapeutic strategies for aggressive prostate cancer
... Progression of aggressive prostate cancers (PCa) with androgen receptor splice variants or neuroendrocrine features is currently untreatable in the clinic. Therefore novel therapies are urgently required. We conducted ...
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Protein interactions at the human topoisomerase II[alpha] promoter : a thesis presented to Massey University in partial fulfilment of the requirement for the degree Doctor of Philosophy in Biochemistry
... the topoisomerase IIα ...for topoisomerase IIα expression can only be speculated by comparison with other ...the topoisomerase IIα promoter in vivo, ChIP assays could be carried ...
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Topoisomerase Inhibitors and Types of Them
... of topoisomerase enzymes (topoisomerase I and II), which are enzymes that control the changes in DNA structure by catalyzing the breaking and rejoining of the phosphodiester backbone of DNA strands during ...
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THIOSEMICARBAZONE COMPLEXES AS VERSATILE MEDICINAL CHEMISTRY AGENTS: A REVIEW
... of Topoisomerase II and DNA interactions Topoisomerase is an enzyme found in eukaryotic cells that causes decatenation of DNA and is necessary for DNA ...[139,140]. Topoisomerase II plays important ...
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Topoisomerase 1 Inhibition Promotes Cyclic GMP AMP Synthase Dependent Antiviral Responses
... of topoisomerase 1 (Top1) by low-dose camptothecin (CPT) can suppress transcriptional induction of antiviral and inflammatory genes and protect animals from excessive and damaging inflammatory ...
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Maternal topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of zebrafish top2a / mutants
... blm arises from a nonsense mutation in the top2a gene To determine the genetic locus of the blm mutation we performed bulk segregant analysis. Linkage to the blm phenotype was found on chromosome 12 with flanking ...
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