TOR signaling
TOR signaling in plants: conservation and innovation
... TORC1 signaling plays a central role in stem-progenitor cell regulation in response to nutrient and energy availability in plants, mice and ...AtTOR signaling generates metabolic signals transmitted within ...
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Spargel/dPGC-1 Is a New Downstream Effector in the Insulin–TOR Signaling Pathway in Drosophila
... growth signaling through mito- chondrial biogenesis: Based on the above observations, we propose an extension of the insulin–TOR signaling pathway in which Spargel is incorporated as a new terminal ...
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An emerging role for TOR signaling in mammalian tissue and stem cell physiology
... metabolism. TOR exists in two complexes, TOR complex 1 (TORC1) and TOR complex 2 (TORC2), which are functionally conserved in ...of TOR, whereas TORC2 has been implicated in cytoskeletal ...
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Dual role for Insulin/TOR signaling in the control of hematopoietic progenitor maintenance in Drosophila
... IIS signaling diminishes larval ...the TOR pathway in the fat ...disrupts TOR signaling and is sufficient to mimic diet restriction (Colombani et ...IIS/TOR signaling is active ...
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Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in Drosophila
... by TOR, could account for a portion of the effect of TOR on protein synthesis and cell size in S2 cells, although not the total effect (Figure ...and TOR, is a non-essential gene product that has ...
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Somatic stem cell differentiation is regulated by PI3K/Tor signaling in response to local cues
... PI3K/Tor signaling – a prerequisite for differentiation – ...PI3K/Tor signaling, suggesting that differentiation signals play a key role in downregulating stem cell ...
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The role of juvenile hormone and insulin/TOR signaling in the growth of Manduca sexta
... insulin/TOR signaling also regulates the terminal growth period in the black ...insulin/TOR signaling and JH signaling provide two distinct mechanisms for determining the final size of ...
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Rhb1 Regulates the Expression of Secreted Aspartic Protease 2 through the TOR Signaling Pathway in Candida albicans
... Recent research links the small GTPase Rhb1 to TOR signaling in C. albicans (72). Rhb1 was first identified in mammals and functions as a positive regulator of mammalian Tor (mTOR) ki- nases (42). In ...
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Drosophila larvae lacking the bcl-2 gene, buffy, are sensitive to nutrient stress, maintain increased basal target of rapamycin (Tor) signaling and exhibit characteristics of altered basal energy metabolism
... Although Tor sig- naling normally inhibits autophagy, the high level of phosphorylated S6K maintained by the mutant was required for precocious starvation-induced ...normal Tor signaling, provided ...
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Genomic Identification of the TOR Signaling Pathway as a Target of the Plant Alkaloid Antofine in the Phytopathogen Fusarium graminearum
... ABSTRACT Antofine, a phenanthroindolizidine alkaloid, is a bioactive natural prod- uct isolated from milkweeds that exhibits numerous biological activities, including anticancer, antimicrobial, antiviral, and ...
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The TOR Signaling Pathway in Spatial and Temporal Control of Cell Size and Growth
... (TOR) signaling pathway regulates cellular metabolic status and growth in response to numerous ...of TOR pathway activity is pivotal for both cell mass built up as well as cell cycle progression and ...
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Rheb may complex with RASSF1A to coordinate Hippo and TOR signaling
... The TOR pathway is a vital component of cellular homeostasis that controls the synthesis of proteins, nucleic acids and ...the TOR kinase. Activation of the TOR pathway suppresses autophagy, which ...
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The Human Gut Microbial Metabolome Modulates Fungal Growth via the TOR Signaling Pathway
... The transcriptional profile of C. albicans cells challenged with the GM resembles nutrient starvation and TOR pathway inhibition. As shown above, the microbiota- secreted metabolites restrained the growth of C. ...
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Sestrins Link Tumor Suppressors with the AMPK TOR Signaling Network
... growth, stimulate mTORC1 via inhibitory phosphorylation of TSC2 by AKT[3]. Insulin/IGF1 stimulate Insulin/IGF1 receptor (In/IGF1R), which through the engagement of insulin receptor substrate-1 (IRS1) tethers and ...
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Multifaceted roles of PTEN and TSC orchestrate growth and differentiation of Drosophila blood progenitors
... common TOR- and 4EBP-dependent ...increases TOR signaling and causes LG overgrowth by increasing the number of actively dividing cells that accumulate high levels of phosphorylated (p) 4EBP during a ...
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The TOR pathway interacts with the insulin signaling pathway to regulate C elegans larval development, metabolism and life span
... the Tor mutant ...daf-2 signaling enhances transcription of daf-15, which further stimulates TOR signaling to respond to the elevated nutrients ...of TOR activity and DAF-16- mediated ...
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Targeting TOR dependence in cancer
... First, we need a greater understanding of the mecha- nism of action of TORC1/2 kinase inhibitors in cancer cells. Which cellular processes regulated by TORC1 and/ or TORC2 are relevant to the therapeutic effects? These ...
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Rapamycin enhances survival in a Drosophila model of mitochondrial disease
... of TOR inhibition is the induction of autophagy, a mechanism of bulk degradation in which cytoplasmic cargo are engulfed by double-membraned autophagosomes and trafficked to the lysosome for ...conditions, ...
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Food-Dependent Plasticity in Caenorhabditis elegans Stress-Induced Sleep Is Mediated by TOR–FOXA and TGF-β Signaling
... TOR signaling is active during periods of ample nutrient availability and has myriad effects on cell growth, metabolism, and stress-responsive transcription (Wullschleger et ...that TOR ...
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The Phosphatase Subunit Tap42 Functions Independently of Target of Rapamycin to Regulate Cell Division and Survival in Drosophila
... mediated signaling in yeast, but its role in higher eukaryotes has not been ...to TOR signaling in Drosophila, as disruption of the Tap42 gene does not cause defects in cell growth, metabolism, or ...
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