Total Body Irradiation
Clinical significance of high-dose cytarabine added to cyclophosphamide/total-body irradiation in bone marrow or peripheral blood stem cell transplantation for myeloid malignancy
... AML: acute myelogenous leukemia; BMT: bone marrow transplantation; CBT: cord blood transplantation; CI: confidence interval; CY: cyclophosphamide; GVHD: graft-versus-host disease; GVL: graft versus leukemia; HCT: ...
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Low Dose Total Body Irradiation (600 cGy) as a Conditioning Regimen in Allogenic Hematopoietic Stem Cell Transplant in Children with Acute Lymphoblastic Leukemia
... [8] Van Kempen-Harteveld, M.L., Brand, R., Kal, H.B., Verdonck, L., Hofman, P., Schattenberg, A., Van der Maazen, R., Corneissen, J., Eijkenboom, W., van der Lelie, J., Oldenburger, F., Barge, R., van Biezen, A., Vossen, ...
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Predictive formulas expressing relationship among dose rate, duration of exposure and mortality probability in total body irradiation in humans
... Levin, Young and Stohler [37] published an estimate of the median lethal dose on humans exposed to ionizing total body irradiation and not subsequently treated for radiation sickness. The median ...
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Haploidentical hematopoietic stem cell transplantation without total body irradiation for pediatric acute leukemia: a single-center experience
... utilized with myeloablative (MA) preparative regimen to achieve long-term survival compared to HLA-matched transplantation. Future directions will focus on optimizing conditioning regimens and enhancing ...
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Predictive formulas expressing relationship between dose rate and survival time in total body irradiation in mice
... in total body irradiation without medical support in humans as a function of dose rate and dura- tion of exposure [12]; the formula of the function is con- structed on the basis of animal-model ...
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Total body irradiation
... This factsheet gives information on total body irradiation. This is a radiation treatment that you have been advised to have as part of your conditioning treatment before your stem cell or bone ...
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Low Dose Total Body Irradiation for Relapsed Low Grade Non Hodgkin’s Lymphoma: Experience of National Cancer Institute, Cairo
... Background and Purpose: The relapsed low grade non-Hodgkin’s lymphoma (LG-NHL) is currently incurable disease and the optimal treatment regimen has not determined yet. Low dose total body irradiation ...
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A Clinical Dosimetry Analysis of Total Body Irradiation for Leukemia Patients
... 129 total body irradiation (TBI) on leukemia and bone marrow transplant patients treated in our clinic from 2008 to 2011 and to find out if there is any indication of the necessity of developing a ...
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Pharmacokinetics and dose adjustment of etoposide administered in a medium-dose etoposide, cyclophosphamide and total body irradiation regimen before allogeneic hematopoietic stem cell transplantation
... Allogeneic stem cell transplantation (allo-SCT) has been used to treat patients with hematological malignancies. High-dose intravenous etoposide (ETP) is commonly used with a standard conditioning regimen of cyclophos- ...
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Astaxanthin attenuates total body irradiation-induced hematopoietic system injury in mice via inhibition of oxidative stress and apoptosis
... Astaxanthin (ATX), a natural anti-oxidant, is pre- dominantly found in marine organisms and is the only known carotenoid that can be transported into the brain by transcytosis through the blood–brain barrier [13]. It ...
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THE EFFECTS OF TOTAL BODY IRRADIATION ON SOME ASPECTS OF HUMAN IRON METABOLISM
... Stable baseline levels of Fe59 in red cells were obtained 1 It is felt that a total of approximately 400 ml i.e., 10 plasma radioiron disappearance studies during a period of 50 days did[r] ...
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RADIATION DOSE-RATE EFFECTS ON SELECT BIOMARKERS IN A MOUSE TOTAL-BODY IRRADIATION MODEL
... Bertho and Roy have shown the utility of using Flt3L measurements to assess radiation accident victims in Dakar [14]. In this accident, an iridium-192 source was stored close to a work place for approximately 8 weeks ...
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Allogeneic hematopoietic stem cell transplantation in adult acute lymphoblastic leukemia: potential benefit of medium-dose etoposide conditioning
... The outcomes of adult acute lymphoblastic leukemia (ALL) patients with chemotherapy or autologous hematopoietic stem cell transplantation (HSCT) are unsatisfactory. Therefore, allogeneic (allo) HSCT has been applied to ...
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Non-myeloablative allogeneic hematopoietic cell transplantation following fludarabine plus 2 Gy TBI or ATG plus 8 Gy TLI: a phase II randomized study from the Belgian Hematological Society
... Methods: Here, we report the results of a phase II multicenter randomized study comparing non-myeloablative allo-HCT from HLA-identical siblings (n = 54) or from 10/10 HLA-matched unrelated donors (n = 40) with either ...
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Novel conditioning regimens for bone marrow transplantation
... Total body irradiation was the first conditioning method developed from research of radiation exposure and has been widely used in the conditioning regimens for its powerful immunosuppressive effects ...
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Canine Cyclic Neutropenia: A STEM CELL DEFECT
... Two normal collie dogs were given 1,200 R total body irradiation followed by successful marrow grafts from their grey collie littermates with cyclic hematopoiesis. During observation periods of 97 ...
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Is Use of Radiation Hormesis the Missing Link to a Better Cancer Treatment?
... Low-dose Total-Body Irradiation (TBI) therapy offers radiation treatment to cancer patients using the concepts of radiation horme- sis and show very good success ...
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Advances in the pathophysiology and treatment of relapsed/refractory Hodgkin’s lymphoma with an emphasis on targeted therapies and transplantation strategies
... High-dose chemother- apy with or without total body irradiation followed by autologous bone marrow and/or peripheral blood stem cell transplantation for patients with relapsed and refr[r] ...
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Treatment and biological dosimetry of exposed persons. Post-Chernobyl action. Final report. EUR 12558 EN. Radiation Protection Series
... Organisation and logistics Although there hospitals is where presently an patients are increasing number of well equiped treated with high dose total body irradiation and bone marrow tra[r] ...
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Cancer immunotherapy: are we there yet?
... Cancer immunotherapy has already entered the main- stream of oncology [23]. Existing strategies focus on en- hancing immune destruction of cancer cells by a variety of means (Table 1). One of the most successful and ...
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