TP53 mutation
Original Article A case of secondary chondrosarcoma with TP53 mutation arising from fibrous dysplasia
... and TP53 muta- tions in this ...the TP53 followed by direct sequencing with previ- ously described primer pairs [8, 9] was also performed on the tumor, FD area, and corre- sponding non-tumoral ...the ...
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TP53 mutation characteristics in therapy-related myelodysplastic syndromes and acute myeloid leukemia is similar to de novo diseases
... [17,19,23], TP53 mutations were highly associated with a complex karyotype and frequent deletions involving chromosome 5 in ...that TP53 mu- tation correlated with a higher number of structural and ...
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WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma
... for TP53 wild- type patients was 86.8% ± 4.7% versus 36.6% ± 8.7% for TP53 mutant ones (p < ...the TP53 wild-type and 100% for the TP53 mutant cases (p = ...between TP53 mutant and ...
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Number of rare germline CNVs and TP53 mutation types
... the TP53 DNA binding domain site (DBD) relative both to controls and to carriers of the mild TP53 Brazilian ...penetrant TP53 mutation provides a plausible explan- ation for anticipation in ...
6
TP53 mutation hits energy metabolism and increases glycolysis in breast cancer
... between mutation in the commonly mutated tumor suppressor gene TP53 and ...comprising mutation and RNA-seq expression data of the TCGA repository and performed receiver operating characteristics ...
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Recurrence pattern and TP53 mutation in upper urinary tract urothelial carcinoma
... (TP53 mutation with A:T to T:A SBS), NAT group (TP53 mutation with only other than A:T to T:A SBS), and WT group (wild- type TP53), ...of TP53 mutation patterns was shown ...
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Psychosocial morbidity in TP53 mutation carriers: is whole-body cancer screening beneficial?
... germline TP53 mutation on their lives and their families was apparent, irrespective of the ...a TP53 mutation impacted on the whole family system and meant those interviewed could often not ...
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Baseline results from the UK SIGNIFY study: a whole-body MRI screening study in TP53 mutation carriers and matched controls.
... in TP53 mutation carriers with no cancers identified in controls ...in TP53 mutation carriers is around 3% [21] therefore the prevalence in study of ...included TP53 mutation ...
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Case Report Sarcomatous transformation of EGFR and TP53 mutation-positive metastatic adenocarcinoma of the lungs, masquerading as a primary pleomorphic sarcoma of the proximal femur
... Non-small cell lung cancer (NSCLC) accounts for a significant number of cancer-related deaths in the world. Recently, epidermal growth factor receptor (EGFR) tyrosine kinase inhibi- tors (TKIs), such as gefitinib and ...
9
Novel high-grade serous epithelial ovarian cancer cell lines that reflect the molecular diversity of both the sporadic and hereditary disease
... BRCA1/BRCA2 mutation harboring cell lines (OV4485 and OV4453) also each have a somatic TP53 mutation, and they were the only cell lines that exhibited robust tumorigenic potential in SCID ...BRCA1 ...
21
Mutation of Tp53 contributes to the malignant phenotype of Abelson virus-transformed lymphoid cells.
... when only wild-type p53 was detectable and later when mutant p53 was present. When tumors developed, animals were sac- rificed and DNA prepared from the tumor was analyzed to confirm the presence of the Ab-MLV ...
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Mutation spectrum of TP53 gene predicts clinicopathological features and survival of gastric cancer
... of TP53 mutations as well as their relationship to clinicopathological features in GC [14], which may be partly due to difference of patient constitutions or the method for detection of ...of TP53 gene were ...
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TP53 gene mutation analysis in chronic lymphocytic leukemia by nanopore MinION sequencing
... of TP53 occur in about 10 % of untreated CLL patients [6, 7], but up to 50 % in relapsed or refrac- tory cases [8, ...carry TP53 mutations in the remaining allele [10, ...all TP53 defects, while sole ...
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Mutational Analysis of KRAS, BRAF, and TP53 Genes of Ovarian Serous Carcinomas in Korean Women
... 20.0% of low-grade serous carcinomas and 70.6% of high- grade serous carcinomas, which is significantly greater than the incidence of low-grade serous carcinoma, but similar to the incidence of high-grade serous ...
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Clinical outcomes based on multigene profiling in metastatic breast cancer patients
... the TP53 tumor suppressor protein is frequently mutated in ...22] TP53 mutations have been found to confer a poor prognosis in several tumor ...the TP53 is mutated in about 30% of breast ...of ...
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Survival of patients with structurally-grouped TP53 mutations in ovarian and breast cancers
... a TP53 mutation, TP53 mutation type, genomic and codon locations, TP53 DNA CNA, relative TP53 mRNA and p53 protein expression levels, and total number of mutations (considering ...
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Neoantigen screening identifies broad TP53 mutant immunogenicity in patients with epithelial cancers
... each TP53 mutation and flanked by 12 amino acids of WT ...mutated TP53; 12–16 minigenes each) or pulsed with individual WT or mutated peptides corresponding only to the autologous TP53 ...
7
Elevated TNFRSF4 gene expression is a predictor of poor prognosis in non-M3 acute myeloid leukemia
... of TP53 muta- ...with TP53 mutation (N = 15) than TP53 wide type (N = 142, p = ...FLT3 mutation (ITD and point mutations) (N = 45) than in patients carrying FLT3 wild type (N = 112, p = ...
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Immunohistochemical correlates of TP53 somatic mutations in cancer
... for TP53 mutation ...predict TP53 mutation status ...with TP53 missense mutations in the exons 5 to 8 region in prostatic adenocarcinoma ...predicting TP53 status and may ...
11
Baseline Surveillance in Li-Fraumeni Syndrome Using Whole-Body Magnetic Resonance Imaging: A Meta-analysis.
... cancers among TP53 mutation carriers in the National Cancer Institute Li-Fraumeni. 449.[r] ...
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