TRAIL-R
TRAIL R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis
... for TRAIL as targets for cancer ...for TRAIL in the mouse, suppresses inflammation and ...single TRAIL-R allele on the lymphoma-prone Eµ-myc genetic background significantly reduced median ...
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Review Article Meta analysis for association of TRAIL DR4/TRAIL-R1 and DR5/TRAIL-R2 with hepatocelluar carcinoma prognosis
... Hepatocellular carcinoma (HCC) is the sixth most common cancer, which is attributed to the third cause of cancer-related mortality in overall global [1]. Prognosis of hepatocelluar carcinoma is very poor with a just 14% ...
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TRAIL R deficiency in mice enhances lymph node metastasis without affecting primary tumor development
... that TRAIL-R affects neither skin tumor initiation nor benign tumor ...the Trail-r geno- types (Figure 2E), indicating that TRAIL-R does not play a role in malignant invasion of ...
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The Combination of TRAIL Treatment and Cancer Cell Selective Expression of TRAIL Death Receptor DR4 Induces Cell Death in TRAIL Resistant Cancer Cells
... adenoviral-encoded TRAIL. (A) Morphologic observation of apoptosis. TRAIL-resistant HCE4 cells were infected with either Ad-GFP (GFP) or Ad-hTERT DR4 (DR4), and TRAIL- resistant HCE7 cells were ...
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ER stress regulates myeloid derived suppressor cell fate through TRAIL R–mediated apoptosis
... as TRAIL-R1 and CD261; absent in mice) and DR5 (also known as TRAIL-R2 and CD262), 2 decoy receptors, DCR1 (also known as CD263) and DCR2 (also known as CD264), and 1 soluble receptor, osteoprotegerin (OPG) ...
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TRAIL and TRAIL Receptors as Prognostic Markers in Breast Cancer Patients
... cells. TRAIL binds to two pro-apoptotic receptors known as death receptor 4 (DR4/ TRAIL-R1), death receptor 5 (DR5/TRAIL-R2), and two decoy receptors DcR1 (TRAIL-R3), DcR2 (TRAIL-R4) ...
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Inhibition of TRAIL-Induced Apoptosis and Forced Internalization of TRAIL Receptor 1 by Adenovirus Proteins
... concentrations: TRAIL-R1 (M271), 5 g/ml; Fas MAb (M38), 1:4 dilution of culture supernatant; EGFR MAb (Santa Cruz 528), 1 g/ml; TfnR MAb (OKT9), 1:4 dilution of culture ...
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Trichosanthin enhances sensitivity of non-small cell lung cancer (NSCLC) TRAIL-resistance cells
... to TRAIL-relevant ...on TRAIL resistance has not been revealed in non-small cell lung cancer ...TCS-induced TRAIL sensitivity, we administrated TCS to TRAIL-resistance NSCLC cells, and found ...
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Metastasis suppressor function of tumor necrosis factor-related apoptosis-inducing ligand-R in mice: implications for TRAIL-based therapy in humans?
... apoptosis-inducing TRAIL system. Primary skin carcinomas are initially resistant to TRAIL (R), but become sensitized (S) by ...expressing TRAIL are the likely effector cells that kill detached ...
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Brittingham, Sara (2011): Downregulation of endogenous TRAIL and its effect on the human cancer cell line KELLY. Dissertation, LMU München: Medizinische Fakultät
... 1995). TRAIL remains surface-bound or, alternatively, its extracellular domain is proteolytically cleaved from the cell surface or is released in association with micro vesicles to produce soluble TRAIL ...
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Overcoming tumor immune evasion with an unique arbovirus
... to TRAIL-mediated apoptosis ...to TRAIL-mediated apoptosis by sTRAIL, or effector cells: γδCTL and kpDC, expressing membrane-bound TRAIL receptors ...
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Targeting Tumour-Initiating Cells with TRAIL Based Combination Therapy Ensures Complete and Lasting Eradication of Multiple Myeloma Tumours In Vivo
... with TRAIL and DOX significantly reduced the growth of CD138 2 CD34 2 ...of TRAIL receptors and/or downstream signalling components between samples and cell ...of TRAIL R1 and R2 amongst the cells ...
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Critical roles of TRAIL in hepatic cell death and hepatic inflammation
... to TRAIL-induced apoptosis, indicating that TRAIL may not mediate hepatic cell ...in TRAIL-deficient mice and mice treat- ed with a blocking TRAIL ...both TRAIL and its death receptor 5 ...
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TRAIL-functionalized gold nanoparticles selectively trigger apoptosis in polarized macrophages
... trimerized TRAIL binds to the cell surface death receptor 4 (DR4) and death receptor 5 (DR5) and causes the ...of TRAIL reduces the mammary adenocarcinoma growth in mice without obvious toxic effects that ...
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Bcl-xL inhibition by molecular-targeting drugs sensitizes human pancreatic cancer cells to TRAIL
... of TRAIL and ABT- 737 synergistically reduced the viability of AsPC-1 and Panc-1 cells in vitro, as observed in the case with ABT- 263 (Figure ...with TRAIL (1 μg in 50 μL) and/or intraperitoneally ...of ...
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Trail of a Swarm
... title Trail of a Swarm speaks to all of the elements in the complex conversation happening within this ...world. Trail references the physical traces and marks left upon objects and the landscape that are ...
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Distinct effects of TRAIL on the mitochondrial network in human cancer cells and normal cells: role of plasma membrane depolarization
... that TRAIL exerts distinct effects on the mitochondrial networks in malignant cells and normal ...cells. TRAIL induced heavy fragmentation of mitochondria into punctate and their clustering in multiple ...
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How to Build a Paddle Trail in Your Community: The Development of a Statewide Paddle Trail Model for North Carolina.
... Paddle Trail in Your Community videoconference participants, website, and listserv, North Carolina Cooperative Extension employees, the North Carolina Paddle Trails Association, the NCPlan listserv, the ...
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The Relationship Between Past Experience and Multiple-use Trail Conflict
... Area trail system and the people who use ...Service trail managers and planners better meet the present and future needs of trail ...other trail users who were not surveyed, however, your ...
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Chrysin and its potential antineoplastic effect
... Moreover, propolis extract and chrysin sensitizes A549 human lung adenocarcinoma and HeLa human cancer cell lines to TRAIL-induced apoptosis.. Moreover, the TRAIL sensi[r] ...
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