Transcription and Splicing
Functional coupling of transcription and splicing
... of splicing is not completely ...for splicing factor accumulation and instead a more complex and dynamic mechanism for recruitment that involve direct interactions with the nascent RNAs may occur (Kotovic ...
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Murine leukemia virus RNA dimerization is coupled to transcription and splicing processes
... by splicing of the genomic RNA and also by direct transcription of a splice- associated retroelement of MLV ...and splicing events on RNA ...either splicing or transcription from ...the ...
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Alternative Splicing And Transcription Diversity Database
... alternative splicing and transcription diversity database of protein function that as from prediction that the percentage of ...of transcription diversity database of sciences at other developmental ...
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c-MYC empowers transcription and productive splicing of the oncogenic splicing factor Sam68 in cancer
... (pre-mRNA) splicing is oper- ated by the spliceosome, a complex ribonucleoprotein ma- chinery that removes introns and ligates exons to yield the mature mRNA ( 10 ...trans-acting splicing factors ( 10 ). ...
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Alternative splicing of transcription factors genes in muscle physiology and pathology
... These splicing patterns are regulated in a temporal and cell-specific manner by the expression of specialized pre-mRNA binding proteins (RBPs) ...mis-regulated splicing events directly correlate with ...
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Studies on mammalian pre-mRNA splicing : connections to transcription and cancer
... of transcription factors, which, according to some estimates number up to 2500 (Tupler et ...containing splicing factor without an apparent RNA binding domain participates in the regulation of CD44 variable ...
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Rotavirus Infection Alters Splicing of the Stress-Related Transcription Factor XBP1
... stress-regulated transcription factor also involved in mamma- lian host defenses and innate immune ...RNA splicing during rotavirus infection revealed that an additional XBP1 RNA (XBP1es) that corresponded ...
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Biogenesis of intronic mirnas located in clusters by independent transcription and alternative splicing
... independent transcription units, while intronic miRNAs are believed to be processed from the introns of their hosting transcription units and hence share common regulatory mechanisms and expression patterns ...
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Mesenchymal stem cell contact promotes CCN1 splicing and transcription in myeloma cells
... increased transcription and induction of splicing of intron-retaining CCN1 pre-mRNA when cultured in contact with ...induce splicing of CCN1 pre-mRNA in a concentration-dependent ...mRNA ...
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Extensive Alternative Splicing of the Repressor Element Silencing Transcription Factor Linked to Cancer
... silencing transcription factor (REST) is a coordinate transcriptional and epigenetic regulator which functions as a tumor suppressor or an oncogene depending on cellular context, and a truncated splice variant ...
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In Vivo Role of Alternative Splicing and Serine Phosphorylation of the Microphthalmia-Associated Transcription Factor
... microphthalmia-associated transcription factor (MITF) is a basic helix-loop-helix leucine zipper protein that plays major roles in the development and physiology of vertebrate melanocytes and melanoma ...
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Transcription Factors in Cancer: When Alternative Splicing Determines Opposite Cell Fates
... alternative splicing, LEDGF/p75 (exons 1–15) and LEDGF/p52 (exons 1–9 and part of intron ...as transcription co-activators, but they display distinct nuclear patterns, owing to different binding partners ...
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Cellular Splicing and Transcription Regulatory Protein p32 Represses Adenovirus Major Late Transcription and Causes Hyperphosphorylation of RNA Polymerase II
... of splicing of mRNAs derived from the adenovirus major late transcription unit (MLTU) also during a virus ...MLTU transcription was accompanied by an accumulation of both Ser 5- and Ser ...
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Pseudoexfoliation syndrome-associated genetic variants affect transcription factor binding and alternative splicing of LOXL1
... differential transcription factor binding and alternative pre-mRNA splicing, and identified the transcription factor RXRa and regulated coupling of alternative splicing and NMD as a mechanism ...
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The nuclear receptor ERβ engages AGO2 in regulation of gene transcription, RNA splicing and RISC loading
... gene transcription and RNA splicing and ...biogenesis, splicing, and maturation, also pleiotropic factors controlling key functions in the cell, such as CNOT1 (CCR4-NOT transcription complex ...
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Alternative splicing of mouse transcription factors affects their DNA binding domain architecture and is tissue specific
... alternative splicing on protein structure and sheds light on how alternative splicing might regulate transcription factor function in a tissue-specific ...alternative splicing to regulation of ...
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H3K4 demethylase KDM5B regulates global dynamics of transcription elongation and alternative splicing in embryonic stem cells
... for splicing machinery to rec- ognize alternatively spliced exons in the final ...of transcription-coupled splic- ing, where decreased rates of elongating RNAPII Ser2P may lead to dysregulated ...
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Alternative Splicing of Vascular Related Transcription Factors 6 is a Negative Regulator for Wood Associated NACs in Populus trichocarpa.
... alternative splicing is a frequent phenomenon that involves the production of multiple distinct transcript isoforms from a single ...alternative splicing of mRNA often produces a truncated protein rather ...
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Puf4 Regulates both Splicing and Decay of HXL1 mRNA Encoding the Unfolded Protein Response Transcription Factor in Cryptococcus neoformans
... unconventional splicing of the HXL1 mRNA encoding the UPR transcription factor but also HXL1 mRNA ...mRNA splicing represents a novel role for a PUF ...mRNA splicing and stability allows a ...
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Radiation-induced alternative transcription and splicing events and their applicability to practical biodosimetry
... Ellina Macaeva 1,2 , Yvan Saeys 3,4 , Kevin Tabury 1 , Ann Janssen 1 , Arlette Michaux 1 , Mohammed A. Benotmane 1 , Winnok H. De Vos 2,5 , Sarah Baatout 1,2 & Roel Quintens 1 Accurate assessment of the individual ...
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