Transcription Factor 7 Like 2
Genetic associations between Transcription Factor 7 Like 2 rs7903146 polymorphism and type 2 diabetes mellitus: a meta-analysis of 115,809 subjects
... Transcription Factor 7 Like 2 (TCF7L2) gene encodes T cell transcription factor 4, a transcription factor of the Wnt/β-catenin signaling pathway that is ...
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Complex patterns of direct and indirect association between the transcription Factor-7 like 2 gene, body mass index and type 2 diabetes diagnosis in adulthood in the Hispanic Community Health Study/Study of Latinos
... type 2 diabetes (T2D) [1] and this disparity is widening as compared to non-Hispanic Whites ...The transcription factor-7 like 2 gene ( TCF7L2 ) was the first locus to be ...
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Original Article Transcription factor 7-Like 2 rs12255372, rs7903146 and rs290487 polymorphism is associated with the susceptibility to type 2 diabetes mellitus in a Chinese population
... of transcription factor 7-like 2 is observed in fat cells and pancreatic cells, and this protein shows low expression in bone cells and muscle cells ...a transcription ...
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Association of transcription factor 7-like 2 gene polymorphisms with breast cancer risk in northwest Chinese women
... Genetic variations in transcription factor 7-like 2 (TCF7L2) are associated with cancer risk. This study was conducted to establish the relationship between TCF7L2 polymorphisms ...
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Growing pigs developed different types of diabetes induced by streptozotocin depending on their transcription factor 7-like 2 gene polymorphisms
... The different polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene promote variances in diabetes susceptibility in humans. We investigated whether these genotypes also ...
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The transcription factor 7-like 2 (TCF7L2) polymorphism may be associated with focal arteriolar narrowing in Caucasians with hypertension or without diabetes: the ARIC Study
... glucagon like peptide-1 induced insulin secretion [9], which in turn could lead to a lower postprandial insulin secretion, we might expect to see a stronger effect among patients with impaired glucose ...
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GENETIC SUSCEPTIBILITY OF TRANSCRIPTION FACTOR 7 LIKE 2 GENE VARIANT AND RISK OF TYPE 2 DIABETES IN ASIAN INDIANS
... rs7903146 polymorphism in TCF7L2 gene was carried out using allele-specific polymerase chain reaction (PCR) as described in an earlier study [10]. Genotyping was based on differential amplification due to the presence of ...
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ASPirin Intervention for the REDuction of colorectal cancer risk (ASPIRED): a study protocol for a randomized controlled trial
... of transcription factor binding (transcription factor 7-like 2 (TCF7L2)), colonocyte gene expression, including hydroxyprostaglandin dehydrogenase 15-(NAD) ( HPGD ) and ...
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Association between the TCF7L2 rs12255372 (G/T) gene polymorphism and type 2 diabetes mellitus in a Cameroonian population: a pilot study
... T2DM is the most heterogeneous form of diabetes which is due by interactions between genetic and environ- mental factors. Genome-wide association studies have led to the identification of several susceptibility genes for ...
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Association of TCF7L2 Gene Polymorphisms with T2DM in the Population of Juana Koslay, San Luis Province, Argentina
... for transcription factor 7 like 2 (TCF7L2) are recognized as the strongest common genetic risk factors for Type 2 Diabetes Mellitus (T2DM) across multiple eth- ...genotyped ...
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A conjugate of octamer binding transcription factor 4 and toll like receptor 7 agonist prevents the growth and metastasis of testis embryonic carcinoma
... All experiments were routinely performed in groups of 8 mice per group. Mice were immunized and challenged with tumors according to the method reported by Vani et al. [21]. Briefly, mice were administrated (i.p.) with ...
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<p>In vivo Screening of Natural Products Against Angiogenesis and Mechanisms of Anti-Angiogenic Activity of Deoxysappanone B 7,4ʹ-Dimethyl Ether</p>
... growth factor Aa; vegfr, vascular endothelial growth factor receptor; fgfr, fibroblast growth factor receptor; COX-2, cyclooxygenase-2; mmp9, matrix metallopeptidase 9; ptp-rb, protein ...
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Quantification of urinary TIMP 2 and IGFBP 7: an adequate diagnostic test to predict acute kidney injury after cardiac surgery?
... Median CPB time was 127 minutes, and median ACC- time was 76 minutes, both of which were longer, but not significantly so, in the KDIGO 1 or 2 group than in the KDIGO 0 group. Patients received in median one red ...
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Krüppel-like factor 4, a novel transcription factor regulates microglial activation and subsequent neuroinflammation
... BV-2 cells, following treatment were washed twice with 1X PBS and lysed in Trizol reagent (Sigma Aldrich) as per the manufacturer ’ s protocol. The RNA was isolated by phenol-chloroform method and it was ...
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Molecular genetics of atrial fibrillation
... The chain of discoveries in complex trait genomics un- covered over the past 2 years using genome-wide association technology is unprecedented [8]. Currently, susceptibility markers for over 70 diseases have been ...
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Notch signaling in pediatric soft tissue sarcomas
... activating transcription factor 2 (ATF2) ...the transcription of ATF2-induced genes, such as cell cycle regulator and apop- totic genes, resulting in tumor cell ...Complex 2 (PRC2), ...
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Occurrence and Significance of the Nuclear Transcription Factor Krüppel-Like Factor 4 (KLF4) in the Vessel Wall
... Krüppel-like factor, was initially considered an epithelial-specific trans- cription factor which participated in the differentiation and growth of the epithelium, namely in the gut and in the ...
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Targeting insulin-like growth factor axis in hepatocellular carcinoma
... IGF-1R monoclonal antibodies in HCC IMC-A12 was studied as a single agent in patients with advanced HCC as a front line systemic therapy. This study unfortunately was terminated due to futility. The pre-planned primary ...
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The Association of rs7903146(C/T) and rs12255372(G/T) Polymorphisms of the TCF7L2 gene with Type 2 Diabetes Mellitus in Chennai Suburban Population
... Type 2 Diabetes has strong genetic ...risk factor ) but not every person who has that particular genetic abnormality will develop Type 2 Diabetes as other risk factors along with life style choices ...
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Dysfunction of various organelles provokes multiple cell death after quantum dot exposure
... activating transcription factor 4; ATF6, activating transcription factor 6; Bak, Bcl-2 antagonist/killer 1; Bax, Bcl-2-associated X protein; Bcl-2, B-cell ...
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