transcriptional activity
Gli1 Transcriptional Activity is Negatively Regulated by AKT2 in Neuroblastoma
... Gli1 transcriptional activity by PI3K/AKT2 signal transduction ...Gli1 transcriptional activity in neuroblastoma cells, whereas, overexpression of an inactive form of PI3K subunit, p85, ...
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Variable Transcriptional Activity of Endogenous Retroviruses in Human Breast Cancer
... consistent transcriptional levels, indicating comparable RNA quality for all 46 RNA ...Differential transcriptional activity was observed, ranging from HERV taxa with ubiquitous or frequent ...
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A temporal switch model for estimating transcriptional activity in gene expression
... of transcriptional activity from time series mRNA expression ...a transcriptional inhibitor, such as actinomycin D, or translational inhibitor, such as ...
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Focal Transcriptional Activity of Murine Cytomegalovirus during Latency in the Lungs
... scripts during latency could thus result from an overall low level of transcriptional activity during latency in combination with a generally low abundance and/or stability of the IE3 mRNA. It is important ...
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Mechanisms that regulate androgen receptor transcriptional activity
... AR transcriptional activity may result from thermodynamic effects on protein structure and protein-ligand interactions ...the activity of T and weaker adrenal ...
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Transcriptional activity of avian retroviral long terminal repeats directly correlates with enhancer activity.
... After we had demonstrated that the FSV LTR is intermediate in transcriptional activity between the LTRs of the endogenous and other exogenous avian retroviruses, it was of interest to de[r] ...
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Prenylation inhibitors stimulate both estrogen receptor α transcriptional activity through AF 1 and AF 2 and estrogen receptor β transcriptional activity
... ER transcriptional activity, using the C3 ...scriptional activity in MCF-7 ...ER-mediated transcriptional activity, many farnesylated proteins are potential candidates for the ...
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Genome-wide predictors of NF-κB recruitment and transcriptional activity
... and stage 2 (AUC = 0.71, MCC = 0.31) enhancers. We found that some codes were ro- bust predictors of p65 binding (Fig. 2d, Additional file 1: Methods). Motif presence has the largest standardized coefficient (log-odds ...
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Gas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehog
... E10.5 and E11.5, sagittal sections demarcated Shh in the pharyngeal endoderm, diencephalon, and facial ectoderm of WT embryos. (C, D, H, and I) Ptc1 and Gli1 demonstrated a gradient of transcriptional ...
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Signal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6
... ferase activity compared with vector ...STAT5b transcriptional activity, and the K219M Brk was also able to significantly enhance this activity (Figure ...STAT5b transcriptional ...
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Simvastatin and downstream inhibitors circumvent constitutive and stromal cell-induced resistance to doxorubicin in IGHV unmutated CLL cells
... and transcriptional activity of HIF-1α are regulated by growth factors and cytokines through the activation of kinase pathways, such as the Ras/ERK1–2 and the PI3k/Akt pathways ...its transcriptional ...
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PES1 promotes breast cancer by differentially regulating ERα and ERβ
... ERβ transcriptional activ- ...tional activity of ERα but enhances that of ERβ should be better than the currently used endocrine drugs tamoxifen or ...
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Cop1 constitutively regulates c Jun protein stability and functions as a tumor suppressor in mice
... lymphomagenesis. Further analysis revealed that c-Jun was a key physiological target for Cop1 and that Cop1 constitutively kept c-Jun at low levels in vivo and thereby modulated c- Jun/AP-1 transcriptional ...
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Nemo like kinase (NLK) acts downstream of Notch/Delta signalling to downregulate TCF during mesoderm induction in the sea urchin embryo
... binding activity, acts primarily as an antagonist of the Wnt ...the transcriptional activity of TCF in the sea urchin embryo, we performed a TCF reporter gene assay using the TOP FLASH construct that ...
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Varicella-zoster virus open reading frame 4 encodes a transcriptional activator that is functionally distinct from that of herpes simplex virus homology ICP27.
... First, it is possible that the upstream elements merely function to boost the basal transcriptional activity of the promoter and that activation by the ORF4 gene product is not discerned[r] ...
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Intrinsic disorder and coiled coil formation in prostate apoptosis response factor 4 (Par 4) : submitted in fulfilment of the requirements of the degree of Doctor of Philosphy, Institute of Fundamental Sciences, Massey University, New Zealand
... As inhibition of NFκB transcriptional activity is not sufficient to induce apoptosis in androgen-independent prostate cancer cells, parallel activation of the Faspathway is essential for[r] ...
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Ebola Virus VP30 Is an RNA Binding Protein
... the transcriptional activity of EBOV requires VP30 and the presence of sequences surrounding the transcription initiation site of NP gene in the leader region ...binding activity for the stem-loop ...
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Eating disorder predisposition is associated with ESRRA and HDAC4 mutations
... the transcriptional activity of ESRRA using an in vitro system to measure ESRRA- induced changes in mRNA levels of known target ...PGC-1α-ESRRA transcriptional activity, indi- cating that ...
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EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer
... inhibited transcriptional activity of the NTD-Gal4 hybrid (Figures 1E, 1F, and Supplementary Figure ...line-specific transcriptional activity, likely due to inefficient expression in PCa cell ...
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Glycogen Synthase Kinase-3β (GSK-3β) and Nuclear Factor Kappa-B (NFKB) in Childhood Acute Lymphoblastic Leukemia
... The activity of GSK-3 can be inhibited by Akt-mediated phosphorylation at Ser21 in GSK-3α and at Ser9 in ...the transcriptional activity of hematopoietic nuclear factor kappa-light-chain-en- hancer ...
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