transcriptional coactivator
Transcriptional Coactivator LEDGF/p75 Modulates Human Immunodeficiency Virus Type 1 Integrase-Mediated Concerted Integration
... Human transcriptional coactivator p75/lens epithelium-derived growth factor (LEDGF) binds human im- munodeficiency virus type 1 (HIV-1) integrase ...
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CARM1 (PRMT4) acts as a transcriptional coactivator during retinoic acid induced embryonic stem cell differentiation
... genes. Coactivator-associated arginine methyltransferase 1 (CARM1, PRMT4) is a protein arginine methyltransferase that also functions as a transcriptional ...
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The Adeno-Associated Virus Type 2 Regulatory Proteins Rep78 and Rep68 Interact with the Transcriptional Coactivator PC4
... described transcriptional coactivator PC4 (18, ...factors. Transcriptional activa- tion by PC4 encompasses different types of activation domains, like the acidic domains of Gal4-AH or VP16, the ...
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The transcriptional coactivator and histone acetyltransferase CBP regulates neural precursor cell development and migration
... Rubinstein-Taybi syndrome (RTS or RSTS; OMIM #180, 849, #613,684), first described in 1963, is a rare but archetypal developmental disorder with multiple con- genital anomalies, intellectual disability and a prevalence ...
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High expression of transcriptional coactivator p300 correlates with aggressive features and poor prognosis of hepatocellular carcinoma
... Transcriptional coactivator p300 has the potential to participate in a variety of cellular functions, such as cell proliferation and differentiation, senescence and apopto- sis ...
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Cellular Transcriptional Coactivator RanBP10 and Herpes Simplex Virus 1 ICP0 Interact and Synergistically Promote Viral Gene Expression and Replication
... To investigate the molecular mechanism(s) by which herpes simplex virus 1 (HSV-1) regulatory protein ICP0 promotes viral gene expression and replication, we screened cells overexpressing ICP0 for ICP0-binding host cell ...
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TRBP maintains mammalian embryonic neural stem cell properties by acting as a novel transcriptional coactivator of the Notch signaling pathway
... Notch transcriptional coactivation complex through C promoter-binding factor 1 (CBF1; RBPJ) and strengthens the association between the Notch intracellular domain (NICD) and CBF1, resulting in increased NICD ...
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The tumor suppressor Nf2 regulates corpus callosum development by inhibiting the transcriptional coactivator Yap
... The corpus callosum connects cerebral hemispheres and is the largest axon tract in the mammalian brain. Callosal malformations are among the most common congenital brain anomalies and are associated with a wide range of ...
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Adeno-Associated Virus Type 2 Rep Protein Inhibits Human Papillomavirus Type 16 E2 Recruitment of the Transcriptional Coactivator p300
... Infection by human adeno-associated virus type 2 (AAV2) is a possible protective factor in the development of cervical carcinomas associated with human papillomaviruses (HPV). The replicative proteins of AAV2 (Rep) have ...
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Identification of Poly(ADP-Ribose) Polymerase as a Transcriptional Coactivator of the Human T-Cell Leukemia Virus Type 1 Tax Protein
... a transcriptional activator, Tax, whose activity is believed to contribute significantly to cellular ...the transcriptional coactivator PC1. PARP functions as a coactivator in our assays at ...
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Epstein-Barr Virus Nuclear Antigen 3C and Prothymosin Alpha Interact with the p300 Transcriptional Coactivator at the CH1 and CH3/HAT Domains and Cooperate in Regulation of Transcription and Histone Acetylation
... the transcriptional coactivator p300 in complexes from EBV-infected ...cellular coactivator p300 with ProT ␣ and demonstrate that the associated activities resulting from this interaction, which ...
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The Human Papillomavirus Type 16 E6 Oncoprotein Can Down-Regulate p53 Activity by Targeting the Transcriptional Coactivator CBP/p300
... a transcriptional activator possibly involved in antiviral cellular responses ...the transcriptional coactivator CBP/p300 to this impressive list of interacting cellular ...important ...
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Recruitment of the Transcriptional Coactivator HCF-1 to Viral Immediate-Early Promoters during Initiation of Reactivation from Latency of Herpes Simplex Virus Type 1
... The transcriptional coactivator host cell factor 1 (HCF-1) is critical for the expression of immediate-early (IE) genes of the alphaherpesviruses herpes simplex virus type 1 (HSV-1) and varicella-zoster ...
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Transcriptional Coactivator CBP Facilitates Transcription Initiation and Reinitiation of HTLV-I and Cyclin D2 Promoter
... CLN-type cyclins (CLN1, CLN2, and CLN3) required for passage through START, the G1 restriction point and transition at G1/S. Three novel types of putative mammalian G1 cyclins were isolated by using human cDNA libraries ...
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Identification of the FHL2 Transcriptional Coactivator as a New Functional Target of the E7 Oncoprotein of Human Papillomavirus Type 16
... a coactivator that enhances transcription at a variety of different promoters, probably through its interaction with several DNA-binding transcription factors (reviewed in reference ...
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Characterization of the ptr6+ Gene in Fission Yeast: A Possible Involvement of a Transcriptional Coactivator TAF in Nucleocytoplasmic Transport of mRNA
... Stutz, F., M. Neville and M. Rosbash, 1995 Identification of a Walker, S. S., W.-C. Shen, J. C. Reese, L. M. Apone and M. R. Green, novel nuclear pore-associated protein as a functional target of 1997 Yeast TAFII145 ...
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Salt inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP dependent hepatic steatosis in mice
... shown in Figure 3E, ChREBP is an acetylated protein, and p300 overexpression enhanced this acetylation. Furthermore, coincuba- tion of HepG2 cells with Lys-CoA-TAT (a cell-permeable p300 HAT inhibitor) abolished the ...
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Polyomavirus Large T Antigen Binds the Transcriptional Coactivator Protein p300
... In contrast to the situation for the binding motifs for pocket proteins, which are present in highly homologous form in E1A, in the T antigens, and in the HPV E7 protein, the status is not as clear with respect to ...
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SCFCdc4 acts antagonistically to the PGC 1alpha transcriptional coactivator by targeting it for ubiquitin mediated proteolysis
... ␣ transcriptional activity was measured directly, indepen- dent of interactions with transcription factors, using a fusion of PGC-1 ␣ to the Gal4-DNA-binding domain (Gal4-DBD) and a Gal4-responsive luciferase ...
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CAPERα Is a Novel Rel-TAD-Interacting Factor That Inhibits Lymphocyte Transformation by the Potent Rel/NF-κB Oncoprotein v-Rel
... selective coactivator for transcrip- tion factors AP-1 and estrogen receptors (26), its association with the v-Rel TAD led us to investigate its effect on v-Rel- mediated ...mediated transcriptional ...
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