Transcriptional network
Identification of a dynamic core transcriptional network in t(8;21) AML that regulates differentiation block and self-renewal
... interacting transcriptional network (Figure ...different network nodes clustered by overlapping but distinct Gene Ontology (GO) terms and KEGG pathways (Figures S4D and S4F; Table S2), indicating ...
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A transcriptional network controlling glial development in the Drosophila visual system
... underlying transcriptional network we silenced all genes encoding predicted DNA-binding proteins in glial cells using ...a network of transcriptional regulators controlling the progression of ...
10
Identification of a dynamic core transcriptional network in t(8;21) AML that regulates Differentiation block and self renewal
... core transcriptional network of t(8;21) AML cells, and then characterized changes in these networks upon RUNX1/ETO ...core transcriptional network, RUNX1/ETO-bound loci are predominantly ...
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BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice
... closely adjacent to but excluded from the proliferative cells (Fig. 6A-B ′ ), suggesting that Klf4 may promote cell differentiation. Moreover, we found that Klf4 expression was restricted to the pre-odontoblast region ...
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Th9 cell development requires a BATF regulated transcriptional network
... factor network downstream of the Th9-inducing signals from IL-4 and ...Th9 transcriptional signature arises from the balanced activity of multiple transcription factors during ...
14
A conserved transcriptional network regulates lamina development in the Drosophila visual system
... Thus, three domains can be distinguished along the lamina differentiation path: 1 NE progenitor cells that express hth and low levels of eya/so anterior to the LF; 2 lamina precursor cel[r] ...
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MED12 regulates a transcriptional network of calcium-handling genes in the heart
... MED12 facilitates cooperative transcription of calcium-handling genes in the heart. To gain an understanding of how MED12 regulates gene expression in the heart, we performed Ingenuity Pathway upstream regu- lator ...
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A Pbx1 dependent genetic and transcriptional network regulates spleen ontogeny
... Heterodimers of Pbx and other TALE proteins of the Meinox family, such as Meis (Bischof et al., 1998; Chang et al., 1997) and Pknox/Prep1 (Berthelsen et al., 1998; Knoepfler et al., 1997; Fognani et al., 2002), form ...
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Dynamic regulation of VEGF inducible genes by an ERK/ERG/p300 transcriptional network
... targeting ERG phosphorylation could be of interest to quell ERG oncogenic activity. Previous studies identified a role for another ETS factor, TEL (ETV6), in the repression, rather than the activation, of DLL4 (Roukens ...
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A bHLH transcriptional network regulating the specification of retinal ganglion cells
... ATH5 transcriptional targets should help answer the question of whether ATH5 is dedicated solely to the production of RGCs or whether it also promotes the development of other retinal ...
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BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network
... Several homeodomain (HD) proteins are critical for skeletal patterning and respond directly to BMP2 as an early step in bone formation. RUNX2, the earliest transcription factor proven essential for commitment to ...
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Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen regulated transcriptional network
... the network is yet to be addressed in detail at the molecular ...the network by regulating the extent and timing of expression of certain transcription factors within the neural tube ...of ...
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Global analysis of the transcriptional network controlling Xenopus endoderm formation
... regulatory network controlling Xenopus endoderm ...that transcriptional repression by Mixer plays a greater role than previously appreciated and that extensive autoregulatory loops exist between Sox17 and ...
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meyerTheseDistrib
... a network inferred from microarray data can be interpreted as a transcriptional regulatory ...network. Transcriptional regulatory network inference aims at giving a global picture of ...
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SIRT1 Deacetylates FOXA2 and Is Critical for Pdx1 Transcription and β-Cell Formation
... the transcriptional network of pancreatic endocrine pro- genitor cells and that PDX1 deficiency blocks pancreas formation, suggesting that PDX1 is essential for pan- creas development and β-cell formation ...
13
Characterization of genome-wide TFCP2 targets in hepatocellular carcinoma: implication of targets FN1 and TJP1 in metastasis
... comprehensive transcriptional network of genes under the control of the transcription factor TFCP2 in HCC cell lines, and identified the direct targets of TFCP2, as well as a number of indirect targets that ...
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Intragraft transcriptional profiling of renal transplant patients with tubular dysfunction reveals mechanisms underlying graft injury and recovery
... intragraft transcriptional network related to proximal tubular dysfunction (PTD) after 12 months of follow-up ...(t12). Network genes were obtained by comparing the intragraft transcriptional ...
12
The HMG box transcription factors Sox1a and Sox1b specify a new class of glycinergic interneuron in the spinal cord of zebrafish embryos
... KEY WORDS: sox1a, sox1b, Spinal cord, Mouse V2c interneuron, Transcriptional network, Development, Zebrafish, Notch, gata2a, gata3, Glycinergic neurotransmission, Axonal projections.. Th[r] ...
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Morphogens, modeling and patterning the neural tube: an interview with James Briscoe
... computational/theoretical. But this was one of a series of papers that we have published over the last 2 or 3 years and in other papers we have combined theoretical/model- ing work and experimental data. For example, the ...
5
delaPena_unc_0153D_14698.pdf
... respective transcriptional network are involved in epigenetic modifications affecting CD4 + T cell differentiation. We postulated that the preferential development of Th2 response in infants is due to ...
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