Transcriptional Silencing
MGA2 and SPT23 Are Modifiers of Transcriptional Silencing in Yeast
... Transcriptional silencing at the HM loci and telomeres in yeast depends on several trans-acting factors, including Rap1p and the Sir ...restore silencing to strains deficient in one or more of these ...
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Importance of the Sir3 N Terminus and Its Acetylation for Yeast Transcriptional Silencing
... that bind specific proteins, ORC, Rap1, and Abf1, which Previous work from our lab suggested that the N ter- in turn attract the silent information regulator proteins, minus of Sir3 is important for the function of the ...
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tRNA Gene Sequences Are Required for Transcriptional Silencing in Entamoeba histolytica
... There remain questions about the specific properties of HM-1:IMSS (2411) that enable transcriptional silencing in this particular strain but not in others. So far, various attempts to identify ...
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Studies on Trans Generational Transcriptional Silencing of cry1Ac Gene in Tobacco Transgenics
... of transcriptional silencing of one specific gene in a transgene ...transgene silencing in higher plants is widely ...gene silencing in plants is a way of warding off potential threat-much ...
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Mcm10 Is Required for the Maintenance of Transcriptional Silencing in Saccharomyces cerevisiae
... RANSCRIPTIONAL silencing in the budding yeast Saccharomyces cerevisiae renders large regions of the genome inactive in a fashion similar to that in hetero- chromatic regions in higher eukaryotes (G rewal and E ...
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Histone H1 of Saccharomyces cerevisiae Inhibits Transcriptional Silencing
... A yeast screen for high-copy modifiers of barrier activity identifies histone H1: To identify yeast proteins involved in transcriptional insulation we designed a genetic screen. It involved a previously described ...
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General transcriptional silencing by a Polycomb response element in Drosophila
... incomplete silencing of miniwhite is the fact that the miniwhite gene in the reporter construct also served as transformation marker to isolate transgenic lines harboring the reporter gene and, hence, only lines ...
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Asynchronous transcriptional silencing of individual retroviral genomes in embryonic cells
... find and act on the multiple loci in a coordinated, syn- chronous manner. The timing of these regulatory events can be tightly synchronous, but there is some inherent noise or variability in the regulatory machinery, and ...
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Mechanisms of Transcriptional Silencing by the Nuclear Piwi Protein in Drosophila Germ Cells
... Zucchini-dependent, phased piRNA biogenesis.. The rhino-deadlock-cutoff complex licenses noncanonical transcription of dual-strand piRNA clusters in Drosophila. RNAi- independ[r] ...
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Epigenetic Inheritance of Transcriptional Silencing and Switching Competence in Fission Yeast
... or clr4 are mutated or deleted but not dramatically so. Im- pairing these functions does not allow much expression of the mating-type genes from the normally silent loci ei[r] ...
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Rational re engineering of a transcriptional silencing PreQ1 riboswitch
... aptamer, at just 34 nucleotides in length (Figure 1A), and is selective for queuosine precursors 7-aminomethyl-7-deazagua- nine (PreQ 1 ) and 7-cyano-7-deazaguanine (PreQ 0 ). 21 Ligand binding stabilizes a H-type ...
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Spt10 and Spt21 Are Required for Transcriptional Silencing in Saccharomyces cerevisiae
... in silencing in ...impair silencing near telo- meres and at the HML ␣ mating type locus, while strength- ening silencing at the ...cause silencing defects, suggesting that Spt10 and Spt21 ...
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Gene-Environment Interactions and Epigenetic Basis of Human Diseases
... Transcriptional silencing by DNA methylation involves a variety of regulatory proteins including DNMTs, methyl-binding domain proteins (MBDs), histone deacetylases (HDACs) and other chromatin remodeling ...
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Rebelo de Andrade, Goncalo N N S (2008): Khd1p, a protein with multiple roles in mRNA localization and telomeric silencing. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... gene transcriptional silencing assay elicited some very interesting results (discussed ...influence transcriptional silencing in Δ rpd3 mutant ...
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Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1
... mediates transcriptional silencing through organizing a higher-order three-dimensionally contracted repressive chromatin compartment (Terranova et ...
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The Nuts and Bolts of Transcriptionally Silent Chromatin in Saccharomyces cerevisiae
... for silencing and whether other deacetylases could substi- tute for Sir2, silent chromatin was assembled in vivo with Hos3, an Rpd3-family deacetylase that neither consumes NAD nor produces OAADPr (Chou et ...
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Understanding the molecular mechanisms of RNA interference in Caenorhabditis elegans
... for transcriptional silencing in the gonad and that loss of rha-1 leads to defects in histone modifications, consistent with a role downstream of siRNA production ...
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Vol 68, No 3 (2016)
... subsequently silencing the expression of a target gene or ...by silencing the target genes has changed the view of gene regulation and this in itself is proposed to be very relevant in practical application ...
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Targeted p16Ink4a epimutation causes tumorigenesis and reduces survival in mice
... fewer spontaneous tumors and ex- hibited significantly longer tumor- free survival. To ascertain the role of p16 promoter methylation in the oncogenic pathway in vivo, we measured p16 promoter methyla- tion and gene ...
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The prognostic potential and oncogenic effects of PRR11 expression in hilar cholangiocarcinoma
... Although the current study sheds light on the pattern of PRR11 expression in six gastrointestinal tumors and potential clinical significance of PRR11 in HC, the potential functions and underlying mechanisms of PRR11 ...
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