Transglutaminase 2
Transglutaminase 2 mediates the biomechanical properties of the colorectal cancer tissue microenvironment that contribute to disease progression
... Abstract: Colorectal cancer is the third most common cancer worldwide, and the fourth leading cause of malignancy-related mortality. This highlights the need to understand the processes driving this disease in order to ...
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Original Article Auxo-action of tissue transglutaminase 2 on tumors in hepatitis B virus-related HCC
... Abstract: It has been reported that tissue transglutaminase-2 (TGM2) possesses the potential to assist in early diagnosis of HCC. The aim of this study was to explore the effects of TGM2 expression on ...
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The Role of Transglutaminase 2 (TG2) in Definition of Cancer Hallmarks
... [55]. Transglutaminase 2 is involved in the modulation of apoptosis and cell fate through many crucial cellular functions (as reviewed in the previous ...
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Evidence that GTP binding domain but not catalytic domain of transglutaminase 2 is essential for epithelial to mesenchymal transition in mammary epithelial cells
... Figure 6 GTP-binding function of transglutaminase 2 is essential for promoting the stem cell phenotype. (A) Fluorescence-activated cell sorting analysis for the mammary stem cell antigenic markers CD44 and ...
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Transglutaminase 2 facilitates the distant hematogenous metastasis of breast cancer by modulating interleukin 6 in cancer cells
... ≤ 2 cm versus > 2 cm), histologic grade (1, 2 versus 3), lymph node status (positive versus negative), and hormone-receptor status (positive versus ...
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Sourdough fermentation of wheat flour does not prevent the interaction of transglutaminase 2 with α2-gliadin or gluten.
... Abstract: The enzyme transglutaminase 2 (TG2) plays a crucial role in the initiation of celiac disease by catalyzing the deamidation of gluten peptides. In susceptible individuals, the deamidated peptides ...
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Transglutaminase 2 cross linking activity is linked to invadopodia formation and cartilage breakdown in arthritis
... Transglutaminase 2 (TG2) is a multifunctional enzyme that has been associated with wound healing and inflam- matory diseases (for review, see ...Ca 2+ ...its transglutaminase (TGase) activity, ...
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Airway epithelial cells initiate the allergen response through transglutaminase 2 by inducing IL-33 expression and a subsequent Th2 response
... Transglutaminase 2 (TG2) is a post-translational pro- tein-modifying enzyme that catalyzes the transamidation reaction, producing crosslinked or polyaminated ...
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Transglutaminase 2 in cartilage homoeostasis: novel links with inflammatory osteoarthritis.
... Osteoarthritis (OA) remains the major disease causing joint degeneration and disability worldwide (Cross et al. 2014). OA is a strongly age-related disorder; however, it can affect young to middle-aged individuals or ...
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The metastatic tumor antigen 1 transglutaminase 2 pathway is involved in self limitation of monosodium urate crystal induced inflammation by upregulating TGF β1
... Gouty arthritis (GA) is a characteristically intense acute inflammatory reaction, which is initiated by precipitation of monosodium urate (MSU) crystals [1]. An attack of is a paradigm for acute sterile self-limited ...
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Transglutaminase-2 interaction with heparin: identification of a heparin binding site that regulates cell adhesion to fibronectin-transglutaminase-2 matrix
... of guanine nucleotide or adenine nucleotide binding (28, 29). In its active conformation, which was resolved on TG2 bound to irreversible active-site inhibitors, Ca 2 ⫹ binding involves a large conformational ...
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Tissue transglutaminase 2 expression is epigenetically regulated in human lung cancer cells and prevents reactive oxygen species-induced apoptosis
... added prior to siRNA transfection of A549 cells (wild-type p53) and H1299 cells of the TP53-null genotype followed by Annexin V/PI staining flow cytometry analysis (Figure 4A). Inhibition of caspase-8 partially reduces ...
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Genomic variants reveal differential evolutionary constraints on human transglutaminases and point towards unrecognized significance of transglutaminase 2
... LOF transglutaminase genes with disease phenotype in the case of F13a (bleeding disorder, prevalence 1 in 2 millions) [60, 61, 62, 77, 78], TGM1 (lamellar ichthyosis, prevalence 1 in 150 thousands) [63, ...
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One click closer to understanding transglutaminase 2
... substrate 2 or BPA as described ...substrate 2 was more efficient than in the previous one (Figure 4, compare lanes 10-12 in panel A with 7-9 in panel ...
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Expression analysis of transglutaminase 2 in premalignant lesions of the cervix
... Methods: This study included 146 patients with suspected LSIL or HSIL detected in routine conventional Papanicolaou tests. The presence of HPV DNA and viral typing was defined by the polymerase chain reaction method ...
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Novel transglutaminase inhibitors reverse the inflammation of allergic conjunctivitis
... A 2 (PLA 2 ), including uteroglobin and lipocortin-1 (annexin ...PLA 2 . Subsequent research showed that PLA 2 is activated by transglutaminase 2 (TGase ...TGase 2 ...
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Plasmodium falciparum liver stage antigen 1 is cross linked by tissue transglutaminase
... hepatocytes and undergo pre-erythrocytic developmental schizogony forming tens of thousands of merozoites per hepatocyte. Shortly after hepatocyte invasion, the parasite starts to produce Liver Stage Antigen-1 (LSA-1), ...
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Anti-transglutaminase 6 antibodies in children and young adults with cerebral palsy.
... Objectives. We have previously reported a high prevalence of gluten-related serological markers (GRSM) in children and young adults with cerebral palsy (CP). The majority had no enteropathy to suggest coeliac disease ...
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Transglutaminase binding fusion protein linked to SLPI reduced corneal inflammation and neovascularization
... Background: To study the effect of topical administration of a fusion protein (PF-MC) made up of N-terminal portion of the protease inhibitor Trappin-2 (which is a substrate of transglutaminasa-2) and SLPI ...
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Effects of Cystamine, a Transglutaminase Inhibitor, in a Mouse Model of Progressive Supranuclear Palsy
... The derivatized samples were separated by a polyacrylamide gel (12%) electrophoresis at 200 volts and transferred onto a nitrocellulose membrane at 100 volts for 2 hours at 16°C. The membranes were then blocked ...
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