translation initiation factors 1
Genome-wide microRNA changes in human intracranial aneurysms
... protein translation machinery, including various eukaryotic translation initiation factors and ribosomal proteins, and this finding was highly correlated with our previous transcriptome data ...
11
Recent insights into eukaryotic translation initiation factors 5A1 and 5A2 and their roles in human health and disease
... type 1 (HIV-1) [51], another study showed that eIF5A1 is primarily localized in the cytoplasm in COS-7, NIH3T3, CV-1, and HeLa S3 cells, but is nearly undetectable in the nucleus [52]; how- ever, ...
13
Picornavirus Internal Ribosome Entry Site Elements Target RNA Cleavage Events Induced by the Herpes Simplex Virus Virion Host Shutoff Protein
... ongoing translation to be targeted by vhs (59, ...for initiation factors that function to recruit ribosomes to the ...with translation initiation factors predicts that the 5⬘ cap ...
10
Ribosomal RACK1 promotes chemoresistance and growth in human hepatocellular carcinoma
... Coordinated translation initiation is coupled with cell cycle progression and cell growth, whereas excessive ribosome biogenesis and translation initiation often lead to tumor transformation ...
14
Sumoylation of eIF4A2 affects stress granule formation
... of initiation complexes that are then recruited to specialised bodies, termed stress ...of translation (Anderson and Kedersha, ...other factors, such as conditions that inhibit eIF4A ...
9
Activation of AP-1-Dependent Transcription by a Truncated Translation Initiation Factor
... a translation initiation factor ...such factors have been shown to affect mRNA stability (30), it was important to address the possibility that Int6CT overexpression might in- crease the stability of ...
11
PubMedCentral-PMC4848592.pdf
... the translation “start” codon ...a translation start site, which almost always consists of an AUG methionine codon in a favorable sequence context ...eIF5 initiation factors position the tRNA ...
16
Translation Initiation Factor eIF4B Interacts with a Picornavirus Internal Ribosome Entry Site in both 48S and 80S Initiation Complexes Independently of Initiator AUG Location
... other initiation factors) to the IRES is the small ribosomal subunit able to enter the IRES ...of initiation com- plexes with the FMDV IRES appears to be a rather slow ...than 1 min (2, ...
10
Translation initiation complex eIF4F is a therapeutic target for dual mTOR kinase inhibitors in non-Hodgkin lymphoma
... suppresses translation. Our data show that CC214-1 treatment causes suppression of mRNA polysome levels without much effect in monosomal ...D3 translation through suppression of the highly ...
14
JBC-1998-Greenberg-23485-94.pdf
... Some initiation factors are known to be involved in translation start site selection, and therefore, must be involved in ...in translation start site selection, and conversely, that mutants of ...
10
Foot-and-Mouth Disease Virus 3C Protease Induces Cleavage of Translation Initiation Factors eIF4A and eIF4G within Infected Cells
... This is the first report that the FMDV 3C protease induces the cleavage of cellular translation initiation factors. The evidence from the transient-expression assays showed that FMDV 3C is able to ...
9
RNA Degradation in Saccharomyces cerevisae
... in translation initiation either directly or indirectly destabilize Pab1 binding the poly(A) ...of translation termination. For example, premature translation termina- tion accelerates poly(A) ...
32
VPg of murine norovirus binds translation initiation factors in infected cells
... 2, 5 and 6, top panels). However, the levels of total eIF4GI, irrespective of its phosphorylation status, were similar in mock and infected cell lysates (Figure 3B) sug- gesting that differences in the amount of ...
7
Functional role of eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) in NSCLC
... eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) is related to tumorigenesis and tumor progression in breast cancer ...protein translation by serving as a scaffold and interacting ...
10
Impaired Binding of Standard Initiation Factors Mediates Poliovirus Translation Attenuation
... in translation reactions with the poliovirus IRES RNAs ...6B), translation of the wild-type IRES was slightly improved, re- flecting a slight increase in product concentration according to the equilibrium ...
8
Complex Alternative Cytoplasmic Protein Isoforms of the Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen 1 Generated through Noncanonical Translation Initiation
... and 1% NP-40 and also supplemented with protease inhibitors (Roche) for 30 min on ...incubated 1 h at room tem- perature in blocking buffer (5% nonfat dry milk, 1 ⫻ Tris-buffered saline [TBS]) and ...
12
Avian Reovirus Nonstructural Protein p17-Induced G2/M Cell Cycle Arrest and Host Cellular Protein Translation Shutoff Involve Activation of p53-Dependent Pathways
... tion phase (S phase) and the nuclear division and cell division phase (M phase), separated by two gap periods (G 1 and G 2 ) (44). Cells progress through each of these phases in a tightly regulated and highly ...
13
Genomic RNA of mengovirus. VI. Translation of its two cistrons in lysates of interferon-treated cells.
... The sequences of mengovirus RNA recognized by ribosomes of interferon-treated cells at initiation of translation were compared with those present in initiation complexes formed by riboso[r] ...
6
Translation initiation at a downstream AUG occurs with increased efficiency when the upstream AUG is located very close to the 5' cap.
... To determine whether the short length of the untranslated leader of this mRNA affects the efficiency of translation initiation at the LP1 initiation signal, monkey cells were transfected[r] ...
5
The Biological Roles of Translation Initiation Factor 3b
... eIF3b-mediated translation for tumor treatment, particularly via the phosphorylation of the eIF3 complex at seven phosphorylation sites (Ser-83, Ser-85, Ser-119, Ser-125, Ser-152, Ser-154, and Ser-164) and one ...
6