Translational control mediated by the primary sequence
Key contribution of eIF4H-mediated translational control in tumor promotion
... in translational control and can promote cellular transformation by preferentially regulating the translation of potent growth and survival factor mRNAs, indicating that eIF4H is a promising new molecular ...
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Translational control of cytomegalovirus gene expression is mediated by upstream AUG codons.
... We show that the presence of either of these two AUG codons delays expression of a downstream ORF for several hours in uninfected human fibroblast cells and that during viral infection t[r] ...
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Quantitative principles of cis translational control by general mRNA sequence features in eukaryotes
... mRNA sequence isoforms used for gener- ating sequence features were those used in the original publications for determining TR and mRNA abundance values for ...
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Translational control of cyclins
... E2F- mediated transcription in late G1, and its protein level is down-regulated by the ubiquitin-proteasome pathway during S ...cause translational inhibition during mitosis ...
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Cytoplasmic polyadenylation mediated translational control of maternal mRNAs directs maternal to zygotic transition
... ABSTRACT In the earliest stages of animal development following fertilization, maternally deposited mRNAs direct biological processes to the point of zygotic genome activation (ZGA). These maternal mRNAs undergo ...
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Virus Mediated Compartmentalization of the Host Translational Machinery
... host translational apparatus to synthesize viral ...the translational machinery within virus-induced inclusions known as viral factories ...the primary site of viral translation within the viral ...
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High-Amplitude Circadian Rhythms in Drosophila Driven by Calcineurin-Mediated Post-translational Control of sarah
... Sin Ho Kweon,* Jongbin Lee,* Chunghun Lim, †,1 and Joonho Choe* ,1 *Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea and † School of Life Sciences, ...
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Translational control of cardiac fibrosis
... following primary antibodies (1:500): alpha-smooth muscle actin (ACTA2, ab7817, abcam), Collagen I (ab34710, abcam) and periostin (POSTN, ab14041, abcam), followed by incubation with the appropriate AlexaFluor 488 ...
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MicroRNAs Act as Cofactors in Bicoid-Mediated Translational Repression
... (A) Sensors carrying the Tribolium castaneum and Haematopota caudal 3 0 UTRs were assayed for their ability to mediate Bcd-dependent repression. The Tribolium caudal 3 0 UTR sensor showed no significant difference in the ...
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Post-Translational Regulation of FAS-Mediated PPARα Activation
... experiment. There was no discernible change in the distribution of FAS between membrane and cytoplasm when cells were treated with insulin (Figure 3C). Given the presence of a putative open reading frame (with a ...
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Translational Control during Calicivirus Infection
... interactions mediated by the caliciviruses VPg and the identification of the determinants required to mediate reinitiation ...mRNA translational reprogramming and (iii) the role of the mTOR pathway in ...
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Translational Control in Plasmodium and Toxoplasma Parasites
... the primary infection may occur in response to various cellular stresses encountered in the new host, such as heat shock (fever), oxidative stress (reactive oxygen species produced from im- mune effector cells), ...
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Nucleotide sequence of the small double-stranded RNA segment of bacteriophage phi 6: novel mechanism of natural translational control.
... (43), who have shown that the neomycin phosphotransferase gene (neo) of transposon Tn5, which is not translated in gram-positive bacteria be- cause it does not have a good gram-positive [r] ...
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Sequence analysis of dolphin ferritin H and L subunits and possible iron-dependent translational control of dolphin ferritin gene
... and translational levels by oxidative stress and cellular iron conditions, respectively ...IRE sequence was present, dolphin leuko- cyte genomic DNA was used because the stem loop formed by the IRE hinders ...
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Translational control mechanisms in the p53 response network
... During my PhD, I collaborated to a project focused on the cooperative interaction between two transcription factors, p53 and NFκB. Indeed, cellular responses to changes in the microenvironment require coordinated ...
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Translational control in the endoplasmic reticulum stress response
... to control translation in response to ER stress ...and translational control are likely to be the first line of defense against ER ...PERK-mediated translational repression is global, ...
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Post-Translational Control of Retinoblastoma Protein Phosphorylation
... Previous work in our lab has identified a specific mutation in the pRB C-terminus, identified as R876F/ F877R, which is able to disrupt Protein Phosphatase 1 binding while retaining CDK2 binding in the analogous region ...
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TRANSCRIPTIONAL AND TRANSLATIONAL CONTROL OF ZEBRAFISH MESODERMAL DEVELOPMENT
... of translational frameshifting is especially interesting to consider in the context of proteome ...protein sequence, structure and ...Regulated translational frameshifting is an additional viable ...
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Determining the Role of Secondary Structure in Translational Control
... in translational regulation a few more transgenic lines need to be ...mutated sequence in the loop, SL1-LM and SL10-LM, need to be analyzed to determine if the sequence of the stem loops is needed ...
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Relief of microRNA-Mediated Translational Repression in Human Cells Subjected to Stress
... Table S1 ). PB enrichment of the mRNA was abolished when cells were transfected with the anti-miR-122 but not control oligonucleotide ( Figure 6 B), indicating that the localization was dependent on miR-122. ...
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