Translational repression
Selective translational repression of HIV 1 RNA by Sam68DeltaC occurs by altering PABP1 binding to unspliced viral RNA
... noprecipitated, the immunoprecipitates run out on SDS- PAGE gels, and the gels exposed to a phosphorscreen over- night (Fig. 2g). The 55 kDa Gag polyprotein (p55) was not detected in the immunoprecipitates from the mock ...
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Keeping a lid on nodal : transcriptional and translational repression of nodal signalling
... Nodal is an evolutionarily conserved member of the transforming growth factor- b (TGF-b) superfamily of secreted signalling factors. Nodal factors are known to play key roles in embryonic development and asymmetry in a ...
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Translational repression of HIF2α expression in mice with Chuvash polycythemia reverses polycythemia
... by dietary Tempol supplementation repressed Hif2α expression, decreased EPO production, ameliorated erythrocytosis/poly- cythemia, and increased the lifespans of these mice (Figure 6). Until recently, phlebotomy therapy ...
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Cell type specific translational repression of Cyclin B during meiosis in males
... under translational repression by action of two interacting factors expressed under control of the germ cell developmental program during meiosis I in male germ cells in ...
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zif 1 translational repression defines a second, mutually exclusive OMA function in germline transcriptional repression
... specific translational repressors in oocytes to global transcriptional repressors in embryos, together effectively repressing transcription in all germline ...
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A single KH domain in Bicaudal C links mRNA binding and translational repression functions to maternal development
... Bicaudal-C (Bicc1) is a conserved RNA-binding protein that represses the translation of selected mRNAs to control development. In Xenopus embryos, Bicc1 binds and represses specific maternal mRNAs to control ...
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A gradient of maternal Bicaudal C controls vertebrate embryogenesis via translational repression of mRNAs encoding cell fate regulators
... Bicc1 translational repression Embryos depleted of Bicc1 developed with expanded dorsal- anterior structures ...Bicc1-mediated repression using a luciferase reporter mRNA assay described in our ...
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Mutant HSPB1 causes loss of translational repression by binding to PCBP1, an RNA binding protein with a possible role in neurodegenerative disease
... its translational repressive ...mediate translational repression through interaction with an RNA binding protein further supporting its role in neurodegenerative ...
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Puf3p induces translational repression of genes linked to oxidative stress
... Puf3p translational control in yeast linked to mitochon- drial function (67), targeting many nuclear encoded genes involved in mitochondrial protein ...mediated translational repression contributing ...
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Vinca alkaloid drugs promote stress-induced translational repression and stress granule formation
... the translational machinery to adapt/ survive chemotherapy treatments [7, ...of translational repression and SG formation, despite the lack of previous reports implicating VA involvement in RNA ...
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Identification of GCD14 and GCD15, Novel Genes Required for Translational Repression of GCN4 mRNA in Saccharomyces cerevisiae
... Identification of GCD14 and GCD15, Novel Genes Required for Translational Repression of GCN4 mRNA in Saccharomyces cerevisiae.. Rafael Cuesta,* Alan G.[r] ...
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Inhibitory Effects of Securinine and Related Compounds on Toxoplasma gondii and Mechanistic Insights into Transcript-Specific Translational Repression in the Bradyzoite Developmental Stage
... 42 eIF2B, thereby turning it into a competitive inhibitor of the nucleotide exchange factor (Sonenberg and Hinnebusch, 2009). In turn, this reduces the turnover of eIF2-GDP, limiting the pool of ternary complex available ...
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Translational Repression of the RpoS Antiadapter IraD by CsrA Is Mediated via Translational Coupling to a Short Upstream Open Reading Frame
... It is well established that RNA binding proteins and RNA structural features present in the 5= leader region of mRNA can regulate translation initiation (20, 21). In some cases, the bound protein directly competes with ...
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miR 122 mediated translational repression of PEG10 and its suppression in human hepatocellular carcinoma
... Previous studies shown that PEG10 highly expressed in hepatoma cell lines and miR-122 downregulated in HCC tissue [4, 7, 39, 40]. These findings imply that expression of miR-122 and PEG10 is inversely related in HCC. We ...
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A Pumilio Domain That Forms Heritable Amyloid Aggregates in Yeast Can Regulate Pumillio-Mediated Translational Repression in Drosophila
... For example, when the amyloid-forming domains of a yeast prion, Sup35, were purified and allowed to form aggregates in vitro at different temperatures, two different [Psi+] phenotypes,[r] ...
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La autoantigen alleviates translational repression by the 5' leader sequence of the human immunodeficiency virus type 1 mRNA.
... Mutational analysis of the 5' non-coding region of human immunodeficiency virus type 1: effects of secondary structure on translation.. Sonen- Downloaded from http://jvi.asm.org/ on Nove[r] ...
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Coronavirus Infection Modulates the Unfolded Protein Response and Mediates Sustained Translational Repression
... We have investigated the UPR during MHV infection. Here, we show that both the IRE1 and ATF6 ␣ pathways are acti- vated during MHV infection; however, only minimal induction of UPR target genes occurs in MHV-infected ...
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The Mechanism of Translational Repression by Iron Regulatory Protein
... A nalogously, the binding of IRP to ferritin, eALAS and m itochondrial aconitase m RNAs leads to low ered iron storage, decreased haem synthesis and increased citr[r] ...
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Translational Control of the Oogenic Program by Components of OMA Ribonucleoprotein Particles in Caenorhabditis elegans
... OMA-1/2-mediated translational repression, dependent on sequences in their 39-untranslated regions ...include translational repressors and activators, and some of these proteins bind directly to ...
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Translational Control of the SigR Directed Oxidative Stress Response in Streptomyces via IF3 Mediated Repression of a Noncanonical GTC Start Codon
... of translational control of the sigma factor SigR and its cognate antisigma factor RsrA that may have broader implications for understanding the expression of other sigma-antisigma ...to repression of SigR ...
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