translocator protein
Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis
... The translocator protein (18 kDa) (TSPO), previously known as the peripheral benzodiazepine receptor, is an integral part of the outer mitochondrial membrane [1] where it forms a complex with other ...
13
Promising potential of new generation translocator protein tracers providing enhanced contrast of arthritis imaging by positron emission tomography in a rat model of arthritis
... Imaging of subclinical arthritis by targeting the translocator protein TSPO on activated macrophages is feasible using R-[11C] PK11195-based positron emission tomography PET, but clinica[r] ...
9
Original Article Expression of 18 KDa translocator protein by microglia in spinal cord and hippocampus in rats with neuropathic pain
... Neuropathic pain (NPP) is spontaneous pain that derives from injury to nervous tissue. The damage changes the structure and function of the nervous system, often leading to a decrease in pain threshold, enhancement of ...
8
Antidepressant-like effects of translocator protein (18 kDa) ligand ZBD-2 in mouse models of postpartum depression
... binding protein; CRH: Corticotropin-releasing hormone; E: Estrogen; EPM: Elevated plus maze; ER: Estrogen receptor; FST: Forced swimming test; GABA: γ -aminobutyric acid; Gln: Glutamine; Glu: Glutamate; HPA: ...
10
Comparison of four 11C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176—based on recent publications that measured specific-to-non-displaceable ratios
... the inflammatory marker translocator protein 18 kDa (TSPO) in several brain disorders. Since then, many sec- ond-generation radioligands have been developed, but un- certainty exists as to whether these are ...
5
A translocator protein 18 kDa agonist protects against cerebral ischemia/reperfusion injury
... The translocator protein 18 kDa (TSPO) is a trans- membrane protein that is primarily localized on the outer mitochondrial membrane [4]. TSPO was first identified as a peripheral-type benzodiazepine ...
9
PET radioligand binding to translocator protein (TSPO) is increased in unmedicated depressed subjects
... jects. Translocator protein 18 kDa (TSPO) is a mitochon- drial protein that transports cholesterol to an enzyme that synthesizes pregnenolone, which is a precursor for ste- roids and neurosteroids ...
9
The Mitochondrial Translocator Protein, TSPO, Inhibits HIV-1 Envelope Glycoprotein Biosynthesis via the Endoplasmic Reticulum-Associated Protein Degradation Pathway
... cellular protein expression in NKR cells and discovered that levels of the mitochondrial translocator protein TSPO were upregulated by ...viral protein expression, and, interestingly, we ...
11
Development of a novel radioligand for imaging 18-kD translocator protein (TSPO) in a rat model of Parkinson’s disease
... 18-kD translocator protein (TSPO), a transmembrane protein, is previously identified as a peripheral benzodi- azepine receptor (PBR), and located in the outer mem- brane of mitochondria of microglia ...
9
Current paradigm of the 18-kDa translocator protein (TSPO) as a molecular target for PET imaging in neuroinflammation and neurodegenerative diseases
... There is accumulating evidence that neuroinflammation plays a crucial role in the development and progression of many neurodegenerative disorders such as MS, AD and HD. Collateral neuronal damage is clearly inherent to ...
9
Evaluation of age-related changes in translocator protein (TSPO) in human brain using 11C-[R]-PK11195 PET
... SPM analysis of SUV images, carried out between adult and children, showed significantly higher PK11195 SUV in adults in the region of the thalamus and the midbrain only ( P = 0.001, cor[r] ...
11
The translocator protein as a potential molecular target for improved treatment efficacy in photodynamic therapy
... In the biosynthetic pathway of heme, coproporphyrinogen III traverses the channel from the matrix to the cytosol [72]. It is theorized by Furre et al. [71] that HAL-induced endogenous PP IX may also advantageously use ...
30
Assessment of safety, efficacy, and dosimetry of a novel 18-kDa translocator protein ligand, [11C]CB184, in healthy human volunteers
... The initial findings of the present study in a small group of subjects indicated that [ 11 C]CB184 PET is feasible for imaging TSPO expression in the brain with an acceptable radiation d[r] ...
9
Targeting translocator protein (18 kDa) (TSPO) dampens pro-inflammatory microglia reactivity in the retina and protects from degeneration
... acidic protein (dilution 1:200; G9269, Sigma, USA), mouse anti-glutamine synthetase (dilution 1:200; MAB302, Millipore, Darmstadt, Germany), and rabbit anti-cone arrestin (Millipore, Darmstadt, ...
12
The Use of Translocator protein 18 kDa (Tspo) as a Biomarker in Various Human Cancers
... Tspo mRNA transcription is observed within specific cell types in normal and cancer tissues of different 65.. organs 66.[r] ...
20
Augmented expression of TSPO after intracerebral hemorrhage: a role in inflammation?
... acidic protein; Hb, hemoglobin; Iba1, ionized calcium binding adaptor molecule 1; ICH, intracerebral hemorrhage; IL-6, interleukin 6; LPS, lipopolysaccharide; NeuN, neuronal nuclei; PBS, phosphate-buffered saline; ...
14
[18F]FEBMP: Positron Emission Tomography Imaging of TSPO in a Model of Neuroinflammation in Rats, and in vitro Autoradiograms of the Human Brain
... roethoxy-2-oxo-1,3-benzoxazol-3(2H)-yl)-N-methyl- N-phenylacetamide; HAB, high-affinity binder; % ID/g, percentage of the injected dose per gram of wet tissue; Ki, binding affinity; LAB, low-affinity binder; MAB, ...
9
PubMedCentral-PMC4769676.pdf
... the translocator protein TSPO serves as a downstream portal for cholesterol to move to the inner mitochondrial membrane where the side chain of cholesterol is cleaved by ...
34
Activated Microglia in the Brain: Mitochondrial and Cell Membrane Associated Targets for Positron Emission Tomography
... kDa translocator protein (TSPO; originally classified as peripheral benzodiaze- pine receptor = PBR) [32] is not restricted to peripheral organs, but also present in CNS, glial and ependymal ...
32
Cessation of anti-VLA-4 therapy in a focal rat model of multiple sclerosis causes an increase in neuroinflammation
... 18-kDa translocator protein (TSPO) binding radioligand [ 18 F]GE-180 to detect changes in a chronic multiple sclerosis-like focal delayed-type hypersensitivity experimental autoimmune encephalomyelitis ( f ...
9