transmembrane domain
Residues in the Hendra Virus Fusion Protein Transmembrane Domain Are Critical for Endocytic Recycling
... F transmembrane domain (TMD) residues S490 and Y498 were found to be important for correct Hendra virus F recycling, with the hydroxyl group of S490 and the aromatic ring of Y498 important for this ...
13
Structure and activation of the TSH receptor transmembrane domain
... lular domain (ECD) and a transmembrane domain ...N-terminal domain, a leucine- rich repeat domain (LRD) and a hinge region or cleavage ...
18
Role of the Coronavirus E Viroporin Protein Transmembrane Domain in Virus Assembly
... the domain. Insertion of an ala- nine residue into a transmembrane ␣ -helix causes all amino acids on its carboxy side to be rotated by ⬃ 100 degrees, which disrupts the potential helix-helix packing ...
11
Analysis of the Transmembrane Domain of Influenza Virus Neuraminidase, a Type II Transmembrane Glycoprotein, for Apical Sorting and Raft Association
... the transmembrane and cytoplasmic tail, the GPI anchor is responsible for directing the protein to the apical membrane by associating with the detergent-insoluble lipids in the ...and transmembrane proteins ...
8
Epidermal growth factor, latrophilin, and seven transmembrane domain-containing protein 1 marker, a novel angiogenesis marker
... seven transmembrane domain-containing protein 1 on chromosome 1 (ELTD1), an orphan adhesion G-protein coupled receptor, was reported as a regulator of angiogenesis, also involved in cancer progression and ...
8
Evidence for Recycling of Invariant Surface Transmembrane Domain Proteins in African Trypanosomes
... In C. elegans, RME-8 localizes to the limiting membrane of MVBs and is involved in prelysosomal trafficking (17), while Dro- sophila RME-8 colocalizes with multiple compartments, includ- ing clathrin-, Rab5-, and ...
13
A GXXXA Motif in the Transmembrane Domain of the Ebola Virus Glycoprotein Is Required for Tetherin Antagonism
... FIG 1 Mutation of a GXXXA motif in the EBOV-GP TMD is dispensable for GP expression and particle incorporation but slightly reduces GP-driven host cell entry. (A) Sequence of the GXXXA motif in the EBOV-GP wt and LXXXL ...
12
Transmembrane domain interactions in carnitine palmitoyltransferase I
... TM2 domain of rCPT1B behaved very differently from its counterpart in CPT1A, forming dimers and trimers as opposed to the hexamers formed by rCPT1A ...TM2 domain was found to have key role in forming ...
170
Transmembrane Domain Determinants of CD4 Downregulation by HIV-1 Vpu
... from HeLa cells expressing FLAG-Ub and no Vpu or HA-tagged versions of wild-type Vpu, Vpu-S52,56N, or Vpu-W22L, with or without human CD4, were subjected to immunoprecipitation using an antibody to the HA peptide. ...
16
A Transmembrane Domain and GxxxG Motifs within L2 Are Essential for Papillomavirus Infection
... TM domain near the N terminus of L2, consisting of residues 45 to 67 ...TM domain lies just downstream of the epitope for the broadly cross-neutralizing antibody RG-1, comprised of residues 17 to 36 (14), ...
10
Investigation and characterisation of transmembrane domain interactions in Carnitine Palmitoyltransferase 1 Isoforms
... LexA* domain are relatively minor and result in only a few amino acid changes from wildtype LexA so there was potential here for a loss in specificity (Dmitrova, et ...
199
Toxicological analysis on EGFR Protein Inhibitors (Clerodane and Iressa 2) using TOPKAT analysis
... a transmembrane receptor with an extracellular ligand-binding domain, a helical transmembrane domain, and an intracellular tyrosine kinase ...extracellular domain is the first step in a ...
5
Cancer chemotherapy: targeting folic acid synthesis
... mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake. A [r] ...
9
Activation of Lymphocyte Signaling by the R1 Protein of Rhesus Monkey Rhadinovirus
... toplasmic domain (R1C) and deletion mutants derived from it were fused to the extracellular and transmembrane domains of CD8 in order to analyze the contributions of the various ty- rosine-containing ...
10
Search | Preprints
... pass transmembrane protein, consisting of an extracellular domain, a transmembrane domain, a juxtamembrane (JM) segment, a kinase domain, and a C-terminal regulatory tail (Figure 1) ...
24
Generation of a functional, soluble tapasin protein from an alternatively spliced mRNA
... high degree of homology to tapasin and were acquired from the UK HGMP resource centre (www.hgmp.mrc. ac.uk) and sequenced. One of the clones revealed a 2202 bp sequence (Genbank, accession AF067286) that was identical to ...
8
Regulation of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Fusion by a Membrane-Interactive Domain in the gp41 Cytoplasmic Tail
... membrane-spanning domain and the CT was neces- sary for CD4-independent fusion on CXCR4, although addi- tional mutations in gp120 that flanked the coreceptor binding site were also required (28, 29, ...binding ...
11
Cytoplasmic Domain of Sendai Virus HN Protein Contains a Specific Sequence Required for Its Incorporation into Virions
... hydrophobic transmembrane domain, with most of the protein (the external domain) extending extracellularly and a small tail region (the cytoplasmic domain) protruding from the inner surface of ...
8
Meiser, Andrea (2003): Presentation of Recombinant Proteins in Modified Vaccinia Virus Ankara Extracellular Enveloped Virions. Dissertation, LMU München: Fakultät für Biologie
... N-terminal domain on the cytosolic side and expose the C-terminal domain on the extracellular ...extracellular domain of CDV.H and the transmembrane domain of the EEV specific VV ...
111
The Domains of Glycoprotein D Required To Block Apoptosis Depend on Whether Glycoprotein D Is Present in the Virions Carrying Herpes Simplex Virus 1 Genome Lacking the Gene Encoding the Glycoprotein
... ectodomain, transmembrane domain, and cytoplasmic domain, were required to block the fragmentation of cellular DNA induced by the gD⫺/⫺ mutant virus stock and that the three domains need not be ...
7