Transplant rejection
The challenge to detect heart transplant rejection and transplant vasculopathy non-invasively - a pilot study
... Early detection of acute heart transplant rejection is important, as immediate treatment contributes to a lower incidence of rejection complications. The diagnostic gold standard is still an ...
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Tacrolimus in preventing transplant rejection in Chinese patients – optimizing use
... Chinese transplant patients; its in vivo pharmacokinetics, treatment regimen, dose and administration, and adverse- effect profile are influenced by multiple factors, such as genetics and the spectrum of primary ...
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Haptoglobin activates innate immunity to enhance acute transplant rejection in mice
... transplantation have not been identified. Here, we show that haptoglobin, an acute phase protein, is an initiator of this MyD88-dependent inflammatory process in a mouse model of skin transplantation. Necrotic lysates ...
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Cardiovascular magnetic resonance in the diagnosis of acute heart transplant rejection: a review
... platforms, transplant tech- niques and anti-rejection ...tologic rejection [29,30,40-45] and ex-vivo myocardial water content [29,30,40,41] (Table ...in transplant rejection could be ...
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Local expression of B7 H1 promotes organ specific autoimmunity and transplant rejection
... In summary, our findings support the notion that B7-H1 upregu- lation in some peripheral tissues can promote T cell priming and T cell–dependent tissue destruction rather than facilitate T cell toler- ance. The apparent ...
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Predicting outcome of acute kidney transplant rejection using
... acute rejection correlates with the patient’s risk of renal allograft loss over ...acute rejection episodes, which contain relatively low numbers of S100 positive myeloid cells, are resolved less adequately ...
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Quantitative characterization of T-cell repertoire and biomarkers in kidney transplant rejection
... cell-mediated rejection (TCMR) is the most com- mon cause of acute rejection [12], and is a major cause of allograft dysfunction and failure ...of rejection as early as possible, so it can be treated ...
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Nanomedicines in renal transplant rejection – focus on sirolimus
... acute rejection, chronic graft failure, and graft loss associated with this sirolimus- based therapy were 19%, 14%, and 10%, respectively (Kahan ...moderate rejection risk may consider stopping cyclosporine ...
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Prevention trumps treatment of antibody mediated transplant rejection
... heart transplant recipients develop chronic rejection within 10 years — a daunting statistic, particularly for young patients expecting to achieve longevity by enduring the rigors of a ...graft ...
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Ferumoxytol-based Dual-modality Imaging Probe for Detection of Stem Cell Transplant Rejection
... Figure 1: Design and mechanism of a caspase-3-cleavable probe with fluorescence “light-up” signature based on ferumoxytol NPs. (a) The chemical structure of the activated caspase-3-cleavable peptide, KKKKDEVD-AFC, and ...
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T cell immunohistochemistry refines lung transplant acute rejection diagnosis and grading
... lung transplant rejection, which is often overlooked, misgraded, misdiagnosed with conventional H&E examinations, could be improved in sensitivity and specificity ...in rejection grading between ...
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Chronic lung allograft dysfunction following lung transplantation: challenges and solutions
... Chronic rejection is a major cause of death after the first year following lung trans- ...chronic rejection, termed “chronic lung allograft dysfunction”, has been used to encompass a more inclusive ...
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Effect of the adjuvanted (AS03) A/H1N1 2009 pandemic influenza vaccine on the risk of rejection in solid organ transplant recipients in England: a self-controlled case series
... 26 transplant centres in the USA, infections resulted in hospitalisation in 71%, admission to an intensive care unit in 16%, and death in 4% of ...clinical rejection were also reported in SOT recipients ...
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Transplant coronary heart disease: challenges and solutions
... CAV and rejection can occur even in patients without measurable HLA antibodies. Therefore, other antigens that can trigger an immune response injury have been sought. Other antibodies against antigens such as ...
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Etiology and determinants of allograft dysfunction.
... Replication of BK virus, with shedding of infected uroepithelial cells (decoy cells) into the urine occurs in more than one third of renal transplant recipients. [31] The clinical features associated with such ...
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Eliciting preferences using discrete choice experiments in healthcare : willingness to pay, stakeholder preferences, and altruistic preferences
... xxv we sent out questionnaires to the patient, carer, donor, and healthcare worker respondents. In addition to this I organized a separate mailing to live donors and relatives of deceased donors via the British Organ ...
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Design of the DRAGET Study: a multicentre controlled diagnostic study to assess the detection of acute rejection in patients with heart transplant by means of T2 quantification with MRI in comparison to myocardial biopsies
... the fi rst year. 1 These biopsies are usually performed, during day hospitalisation, through a large central venous catheter introduction system (>9 Fr) under radi- oscopy (irradiation). There are con fl icting data on ...
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Eculizumab to Treat Antibody-Mediated Rejection in a 7-Year-Old Kidney Transplant Recipient
... plasmapheresis can be cumbersome, and it can be associated with several complications. The use of a short course of eculizumab (eg, only 2 doses of 600 mg each) could be considered cost-effective for the treatment of ...
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... renal transplant recipients with functioning grafts were enrolled in this study in the period from Janury to December ...renal transplant recipients were identified using a multivariable logistic regression ...
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Eculizumab to Treat Antibody-Mediated Rejection in a 7-Year-Old Kidney Transplant Recipient
... antibody-mediated rejection (ABMR) in a highly sensitized kidney transplant ...kidney transplant in the presence of low donor-specific antibodies ...after transplant, the child continues to ...
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