Transplant tolerance
Development of a cross platform biomarker signature to detect renal transplant tolerance in humans
... and tolerance (17) has been clearly established, the role of B cells and the mechanisms whereby they may contribute to the tolerant state have yet to be ...transplantation tolerance induced by anti-CD45RB ...
15
Constitutive expression of the anti apoptotic Bcl 2 family member A1 in murine endothelial cells leads to transplant tolerance
... of transplant vascular disease ...reduced transplant arteriosclerosis in a mouse aorta, to carotid artery, allograft model ...towards transplant tolerance ...
23
IL 34 is a Treg specific cytokine and mediates transplant tolerance
... (10). However, studies have demonstrated that IL-34 and M-CSF display distinct biological activity and signal activation (11), in part due to their differing spatial and temporal expression (12). Up to now, IL-34 ...
14
Transient antibody targeting of CD45RC induces transplant tolerance and potent antigen-specific regulatory T cells
... induced transplant tolerance associated with inhibition of allogeneic humoral responses but maintained primary and memory responses against cognate ...donor-specific tolerance to grafted ...
21
Th1 cytokines, programmed cell death, and alloreactive T cell clone size in transplant tolerance
... for tolerance induction across multiple minor histocompatibility ...peripheral tolerance to fully allogeneic transplants by T cell cos- timulatory blockade (8, 10–12, ...achieve transplant ...
10
Immunostimulatory Tim 1–specific antibody deprograms Tregs and prevents transplant tolerance in mice
... Discussion In a study of the allograft response, we demonstrate that administration of 3B3 agonist anti–Tim-1 mAb prevents the induction of peripheral-type transplant tolerance by a enha[r] ...
8
Mesenchymal stem cells overexpressing IL-35: a novel immunosuppressive strategy and therapeutic target for inducing transplant tolerance
... allograft tolerance may be induced by changing the Th1/Th2 balance ...kidney transplant- ation has been gradually ...allograft tolerance by the induction of Tregs and, to some extent, this is ...
8
Identification of a B cell signature associated with renal transplant tolerance in humans
... renal transplant recipients, as defined by stable graft function and receiving no immunosuppression for more than 1 year, and compared their gene expression profiles and peripheral blood lymphocyte subsets with ...
13
Working toward immune tolerance in lung transplantation
... Long-term allograft survival is a major challenge facing solid organ trans- plantation. Recent studies have shown a negative correlation between infil- tration of memory T cells and allograft survival. Furthermore, ...
5
Single-cell transcriptomics reveal that PD-1 mediates immune tolerance by regulating proliferation of regulatory T cells
... during transplant tolerance is not ...peripheral tolerance as PD-1 knockout mice spontaneously develop autoimmunity with markedly augmented proliferation of conventional T cells ...
14
Influences of Donor and Recipient Gene Polymorphisms on Tacrolimus Dosing and Pharmacokinetics in Asian Liver Transplant Patients
... multi-organ transplant; 3) there was evidence of graft rejection (acute cellular, ductopenia or chronic) within 3 months prior to study participation; 4) they had active infection, auto- immune hepatitis or active ...
9
Illness, normality and identity:the experience of heart transplant as a young adult
... IPA requires that assumptions and preconceptions are bracketed off to prevent them from influencing the research process 28 . The first author (who conducted the interviews and led the analysis) recorded her thoughts, ...
26
Rapid Recovery of Diabetes Two Months after Discontinuation of Tacrolimus (FK-506) in a Single Lung Transplant Patient
... renal transplant patients within three years after the procedure, contributes to post-transplant morbidity and mortality by increasing the risk of infection and cardiovascular ...lung transplant ...
5
Association of depression and anxiety before heart transplant with mortality after transplant: a single-center experience
... explanation is that patients with a pre-transplant history of hypertension tolerate higher doses of angiotensin-converting enzyme inhibitors and β -blockers and that this confers some “carryover” benefit to the ...
8
The transplant iron score as a predictor of stem cell transplant survival
... the transplant setting, we sought to methodically examine iron status among transplant ...resulting Transplant Iron Score assigns a point for each of the following variables: (1) greater than 25 red ...
9
Isolation and Characterisation of Candida Species From Post- Renal Transplant Recipients with Urinary Tract Infection with Special Reference to Echinocandins
... RENAL TRANSPLANT RECIPIENTS WITH URINARY TRACT INFECTION WITH SPECIAL REFERENCE TO ECHINOCANDINS”is the bonafide work done by me at Institute of Microbiology, Madras Medical College under the expert guidance and ...
132
Between the two parties to a deceased donor transplant: analysis of a transplant coordinator's ethical position between the recipient and the donor's family
... their transplant and donor families with their ...the transplant gives them a good feeling and satisfaction about their decision to donate the organ (Colarusso, 2006; Lopez Martinez et ...the ...
7
Intrapulmonary Recombinant Factor VIIa for Diffuse Alveolar Hemorrhage in Children
... Treatment of diffuse alveolar hemorrhage after allogeneic bone marrow transplant with recombinant factor VIIa. Bone Marrow Transplant[r] ...
7
Barriers to living donor kidney transplantation in the United Kingdom : a national observational study
... kidney transplant recipi- ents were recruited at the time of transplantation from all 23 UK renal transplant ...kidney transplant recipient population (data not shown) ...
12
Study the Results of combination therapy with Thalidomide - Dexamethasone in Newly Diagnosed patients with Multiple Myeloma.
... of days of antibiotics Post ASCT status of myeloma Post transplant progressive disease Post transplant relapse date Post ASCt maintenance Post transplant maintenance duration Post transp[r] ...
111