Transporter Proteins
Molecular dynamics study of neurotransmitter reuptake mechanism on modeled transporter proteins
... The crystal structure of DAT, SERT and NET wasn’t available at the PDB[41].The amino acid sequence of DAT, SERT and NET were retrieved from Uniprot [42] server. The three dimensional structures of the obtained sequences ...
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Contributions of Aspergillus fumigatus ATP-Binding Cassette Transporter Proteins to Drug Resistance and Virulence
... (ABC) transporter proteins has been found to be increased and correlates with a concomitant elevation in azole drug ...fumigatus proteins that share high sequence similarity with ...ABC ...
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Immunolocalization and Cellular Expression af Key Abc Transporter Proteins and Their Correlation with the Grades and Subtypes of Canine Mammary Tumour
... Canine mammary tumour (CMT) is the second most common neoplasm after skin tumours [1-4], and nearly half of them are malignant [3-5]. Their clinicopathological and histopathological features, and hormonal behaviour are ...
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The responses of zebrafish (Danio rerio) to high external ammonia and urea transporter inhibition: nitrogen excretion and expression of rhesus glycoproteins and urea transporter proteins
... Rh proteins are necessary to move ammonia throughout, as well as out of, the ...Rh proteins used by fish and where they occur appear to be highly ...
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Stability of multiple alignments and phylogenetic trees: an analysis of ABC-transporter proteins family
... One reason for the instabilities of the alignments con- structed for the set of ABC transporters under investiga- tion is the repetitive structure of three of its sequences. In a last step, we will therefore decompose ...
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The dual role of Escherichia coli in the course of ulcerative colitis
... [25]. Hydroxyl radicals can react with almost all sub- stances and can cause the peroxidation of lipids, the dis- ruption of cell membranes, and the inhibition of enzymes that transport Ca 2+ and Mg 2+ ions across mem- ...
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Cancerous multi drug resistance is reduced by Leptomycin B treatment in CCRF CEM/Taxol cellsCancerous multi drug resistance is reduced by Leptomycin B treatment in CCRF CEM/Taxol cells
... Increasing drug efflux predominantly via ATP-driven extrusion pumps frequently of the ATP-banding cassette (ABC) superfamily may be the major of modalities of chemotherapeutic drug resistance. P-glycoprotein (P-gp) and ...
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Expression and regulation of drug transporters in vertebrate neutrophils
... drug transporter proteins Figure ...SLC transporter proteins in zebrafish (branch lengths are not proportional to genetic distance; see Supplementary ...expressed proteins are marked ...
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Targeting the Zinc Transporter ZIP7 in the Treatment of Insulin Resistance and Type 2 Diabetes
... zinc transporter proteins that control subcellular organelle zinc and cytosolic intracellular zinc concentrations ...the proteins that transport this metal ion have been linked to ER stress and ...
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Control of Plasma Membrane Permeability by ABC Transporters
... The vast majority of phenotypes caused by loss of the ABC trans- porters Pdr5 and Yor1 involve increased sensitivity to many chemically dissimilar drugs (62). Our finding here of the large increase in resistance to the ...
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The peptide transporter 1a of the zebrafish Danio rerio, an emerging model in nutrigenomics and nutrition research: molecular characterization, functional properties, and expression analysis
... The question whether or not teleost PepT1a-type trans- porters are functional has been answered recently, with first cloning, analysis of sequence, tissue expression of Atlantic salmon pept1a ( slc15a1a ), and its ...
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Effects of galacto-oligosaccharides on growth and gut function of newborn suckling piglets
... A good mechanical barrier can effectively prevent bacteria, endotoxins, and other harmful substances from penetrating the intestinal mucosa, and in terms of infrastructure, it functions as a tight junction be- tween the ...
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Bioinformatic Survey of S Layer Proteins in Bifidobacteria
... acidic proteins or glycoprote- ins, contain 40% - 60% hydrophobic amino acids, and possess few or no sul- fur-containing amino acids ...the proteins range from 4 to 6. However, pIs of the S-layer ...
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Dynamic interaction of genetic risk factors and cocaine abuse in the background of Parkinsonism – a case report
... We detected only one genetic risk variant, which was previously associated with PD. The presence of this homozygous LRRK2 polymorphism (S1647 T) has a very mild association with PD, with a low odds ratio (in our cohort ...
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Important genetic checkpoints for insulin resistance in salt-sensitive (S) Dahl rats
... inflammatory proteins such as tumor necrosis factor-alpha (TNF-α), c-Jun Terminal Kinase (JNK) and nuclear factor-kappa B, (NF-kappa B) which increases oxygen consumption and produce many reactive oxygen species ...
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The use of SMALPs as a novel membrane protein scaffold for structure study by negative stain electron microscopy
... of proteins from membranes with potentially destabilising detergents and their subsequent reconstitution into a non-natural lipid environment, the use of styrene maleic acid co- polymer (SMA) enables ...
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Identification of Residues in the Lipopolysaccharide ABC Transporter That Coordinate ATPase Activity with Extractor Function
... ABSTRACT The surface of most Gram-negative bacteria is covered with lipopolysaccharide (LPS), creating a permeability bar- rier against toxic molecules, including many antimicrobials. To assemble LPS on their surface, ...
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Expression of the Genes OsNRT1 1, OsNRT2 1, OsNRT2 2, and Kinetics of Nitrate Uptake in Genetically Contrasting Rice Varieties
... To analyze the expression of the nitrate transporter genes with low (OsNRT1.1) and high affinity (OsNRT2.1 and OsNRT2.2) and to determine the uptake kinetics parameters, four genetically contrasting rice varieties ...
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cocaine piperidine based analogs sar 2 pdf
... The synthesis and monoamine transporter activity of additional members of a series of 3,4- disubstituted piperidines (truncated analogues of the WIN series) are described. All members of this series were prepared ...
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Sotagliflozin, the first dual SGLT inhibitor: current outlook and perspectives
... Sotagliflozin is a dual sodium–glucose co-transporter-2 and 1 (SGLT2/1) inhibitor for the treatment of both type 1 (T1D) and type 2 diabetes (T2D). Sotagliflozin inhibits renal sodium–glucose co-transporter ...
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