Treg function
TSLP directly impairs pulmonary Treg function: association with aberrant tolerogenic immunity in asthmatic airway
... pulmonary Treg were incu- bated with 50 pg/ml TSLP for 18 hours before being subjected to downstream ...ary Treg did not exhibit increased proliferation (Addi- tional file 1, Figure ...pulmonary Treg ...
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High self-reactivity drives T-bet and potentiates Treg function in tissue-specific autoimmunity
... of Treg lineage commitment during thymocyte development, as Tregs generally express TCRs with stronger self-reactivity in comparison with conventional T cells (Tconvs) (10, ...for Treg-suppressive ...
15
OX40L/OX40 axis impairs follicular and natural Treg function in human SLE
... with Treg dysfunction in patients with active ...affects Treg function, we hypothesized that OX40L signals may also effect the suppressive func- tion of Tfr ...
14
Review Article Regulatory T cells and B cells: implication on autoimmune diseases
... Foxp3+ Treg cells, and compared their reactivi- ty to those derived from healthy ...defective Treg function does not impact central B-cell ...
7
Genetic and epigenetic studies of FOXP3 in asthma and allergy
... addition, a positive correlation was observed between FOXP3 methylation and exposure to chronic diesel ex- haust particles (DEP) (4.01 %, 95 % CI 1.83–6.18 %; in- crease in FOXP3 methylation per interquartile range ...
10
<p>The Role Of PD-1/PD-L1 Axis In Treg Development And Function: Implications For Cancer Immunotherapy</p>
... immunosuppressive function of Treg is modulated by plenty of mechanisms, including direct engagement with cells through costimulatory signals via OX40, PD-1 and their ligands and indirectly by cytokine ...
9
Physical activity, black carbon exposure, and DNA methylation in the FOXP3 promoter
... lung function, particularly in individuals with asthma, by suppressing pro-allergic immune responses via the T regulatory (Treg) cell pathway [10, ...and function of Tregs isolated from the lung and ...
12
Tuning mTOR activity for immune balance
... diet. Treg cells mediate immune tolerance toward these antigens, preventing effec- tor T cell activation and undesired intes- tinal ...impaired Treg function and stability under inflammatory condi- ...
5
Cyclin-Dependent Kinase 2 Regulates Foxp3 and Regulatory T Cell Function
... and function of regulatory T cells ...Foxp3+Treg function, but the mechanism by which this occurred was not ...increased function compared to cells transduced with wild-type Foxp3 as measured ...
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How to detour Treg cells in T cell-based antitumor immune therapy
... the Treg cell able to sense the peripheral abundance of effector immune cells, and would the load of effector cells have feedback on Treg function? Does the increased Treg portion in the ...
5
Phenotypic and functional testing of circulating regulatory T cells in advanced melanoma patients treated with neoadjuvant ipilimumab
... immunosuppressive function through pro- duction of adenosine [19], and they have been found in increased levels in cancer patients ...of Treg fre- quency after treatment and the Treg suppressive ...
8
Original Article Regulatory function of TH17/Treg ratios in the children suffering from adenoidal hypertrophy with complications
... and Treg cells showed significant changes in children with ...of Treg cells. Whether the changes of Treg and Th17 ratios are different from those of RORγT and Foxp3 transcription factors complicated ...
10
Epigenome targeting by probiotic metabolites
... ity of probiotics and their metabolites are associated with chromatin remodeling as a function of intrinsic histone deacetylase inhibition. Modulation of gene tran- scription is an essential component of many ...
5
The roles of serum CXCL16 in circulating Tregs and gastrointestinal stromal tumor cells
... All experiments were performed in triplicate, and the results were expressed as the mean ± standard deviation. Data were analyzed using GraphPad Prism 5 software (GraphPad Software Inc., La Jolla, CA, USA). Statistical ...
11
hPMSC transplantation restoring ovarian function in premature ovarian failure mice is associated with change of Th17/Tc17 and Th17/Treg cell ratios through the PI3K/Akt signal pathway
... diseases. Treg cells secrete immunosuppressive cytokines to suppress the immune response, while Th17 cells can in- crease the immune response via the release of inflamma- tory cytokines [14, ...cytotoxic ...
14
The changes and its significance of Th17 and Treg cells and related cytokines in patients with tuberculosis pleurisy
... cells, and some previous researches indicated that IL-23 and IL-17 could inhibit the function of Treg cells [19,20]. But we found no theoretical basis to support that idea. IL-6 is a cytokine secreted by ...
6
Expanded B cell population blocks regulatory T cells and exacerbates ileitis in a murine model of Crohn disease
... To test regulatory cell function in the well characterized CD45RBhiCD4+ and CD25+CD4+ T cell adoptive transfer models 14 using Treg populations that overlap with the αE+CD4+ population 1[r] ...
11
Therapeutic Effect of Ergotope Peptides on Collagen-Induced Arthritis by Downregulation of inflammatory and Th1/Th17 Responses and Induction of Regulatory T Cells
... immunosuppressive function of CD4 + CD25 + regulatory T cells (Treg) from the group treated with ergotope peptides was significantly in- creased when we cocultured them with CD4 + CD25– effect T cells ...by ...
13
Interleukin-35 on B cell and T cell induction and regulation
... mouse IL-35R differed from traditional cytokine receptors. IL-35R is composed of dimers which are IL-12Rβ2 homo- dimers, gp130 homodimers or IL- IL-12Rβ2/gp130 het- erodimer [6]. IL-35 binds to IL-35R and initiates ...
7
Signals Controlling Regulatory T Cell Differentiation and Homeostasis
... preferential Treg division increased significantly with the addition of GM-CSF (Figure ...on Treg division (Figure ...the Treg division that is observed in GM-CSF-treated splenocyte cultures may ...
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