TRIALS WITH RADIOTHERAPY ALONE
Original Article Radiotherapy plus procarbazine, lomustine, and vincristine versus radiotherapy alone for glioma: a meta-analysis of randomized controlled trials
... controlled trials (RCTs) have explored the efficacy of radiotherapy combined PCV in treatment of gliomas [8, ...RT alone for glioma patients after ...
9
A systematic review of randomised controlled trials of radiotherapy for localised prostate cancer
... controlled trials were included when they reported on adult men (>18 years) with prostate cancer, treated with any form of radiotherapy (EBRT and/or BT), alone or in combination with HT or RP, in ...
23
Late normal tissue effects in the arm and shoulder following lymphatic radiotherapy: Results from the UK START (Standardisation of Breast Radiotherapy) trials.
... testing radiotherapy versus surgery of the axilla after a positive sentinel node biopsy, lymphoedema was reported less often when defined as an increase in arm circumference of ≥10% (6% rate at 5 years) compared ...
25
Prolongation of overall treatment time as a cause of treatment failure in early breast cancer: An analysis of the UK START (Standardisation of Breast Radiotherapy) trials of radiotherapy fractionation.
... in radiotherapy exists for squamous carcinomas of the head and neck, where at least ...adjuvant radiotherapy following primary surgery for early breast cancer, where studies are limited to exploring the ...
18
Study protocols of three parallel phase 1 trials combining radical radiotherapy with the PARP inhibitor olaparib
... radical radiotherapy regi- men including a radiosensitiser that potentially even worsens ...radical radiotherapy are clinically accepted [ 59 ...accelerated radiotherapy, only ex- cluding HPV ...
14
<p>Moderate hypofractionated radiotherapy vs conventional fractionated radiotherapy in localized prostate cancer: a systemic review and meta-analysis from Phase III randomized trials</p>
... tionated radiotherapy (H-RT) delivered fewer fractions each with a higher dose, which significantly increased resource use and improved patient convenience, and thus had been a promising treatment in the past ...
10
Health care and research: Clinical trials in cancer radiotherapy
... Many elements are Involved In properly conducting a clinical trial. Among the most Important are the research protocol. It needs to define the trial's objectives; tumour type; stage of d[r] ...
5
Current clinical trials testing the combination of immunotherapy with radiotherapy
... Another approach for enhancing anti-tumor immunity is vaccination through presentation of tumor antigens on recombinant viral vectors. The combination of tumor vac- cines with RT has shown promise in preclinical settings ...
20
Accelerated or hyperfractionated radiotherapy for esophageal carcinoma: a meta-analysis of randomized controlled trials
... acute tracheitis 1.04 0.33 esophageal perforation 0.33 0.75 esophagorrhagia 0.23 0.83 Various schedules of HF and AF of RT in randomized clinical trials have proven to be superior to standard frac- tionation in ...
11
Adverse events reporting in stage III NSCLC trials investigating surgery and radiotherapy.
... Therefore, exact knowledge of side effects of oncological treatment is crucial. In our collective, only 27 studies (22.69%) reported whether patients did not have any AEs (equal to CTCAE “grade 0”). There was a ...
9
Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial
... Trial Design and Treatment NOA-08 (German Cancer Trials Registry ID 386 and NCT01502241) was approved by the ethics committees (EC) of all 23 participating sites. The study was conducted from May 15 2005 through ...
31
Concurrent chemoradiotherapy versus radiotherapy alone for locoregionally advanced nasopharyngeal carcinoma in the era of intensity-modulated radiotherapy: a meta-analysis
... Previous published meta-analyses showed that the addi- tion of concurrent chemotherapy improved prognosis in LANPC patients in the era of 2D-RT. For example, it was reported that the 5-year OS was significantly improved ...
10
Chemotherapy alone versus chemotherapy plus radiotherapy for early stage Hodgkin lymphoma
... involved-field radiotherapy (IF-RT) ( Diehl 2005 ; Engert 2007 ; Meyer 2005 ; MSKCC trial #90-44 ...of radiotherapy and chemotherapy ( Aleman 2003 ; Bhatia 2003 ; Dores 2002 ; Franklin 2005 ; Green 2000 ; ...
97
Bevacizumab plus hypofractionated radiotherapy versus radiotherapy alone in elderly patients with glioblastoma: the randomized, open-label, phase II ARTE trial
... Abstract: Background The addition of bevacizumab to temozolomide-based chemoradiotherapy (TMZ/RT → TMZ) did not prolong overall survival (OS) in patients with newly diagnosed glioblastoma in phase III trials. ...
26
Original Article A Meta-analysis evaluating stereotactic radiotherapy combined with WBRT versus SRT alone for the NSCLC patients with brain metastases
... The inclusion criteria were diagnosis of NSCLC, newly diagnosed brain metastases and no prior radiotherapy, surgery, or other treatments. A literature search was carried out for random- ized controlled ...
9
Comparison of the efficacy between concurrent chemoradiotherapy with or without adjuvant chemotherapy and intensity-modulated radiotherapy alone for stage II nasopharyngeal carcinoma
... IMRT alone group, which mainly manifested in aspects like leucopenia, neutropenia, anemia, liver dysfunction, gastrointestinal reaction, and weight loss; while there were no statistically significant differences ...
10
Concurrent weekly single cisplatin vs triweekly cisplatin alone with radiotherapy for treatment of locally advanced cervical cancer: a meta-analysis
... Dovepress Triweekly vs weekly cisplatin plus concurrent RT in LACC the 1990s. However, in an RCT by Ryu et al triweekly single CDDP chemotherapy concurrent with RT was associated with better 5-year survival and lower ...
11
Comparison of long-term survival between temozolomide-based chemoradiotherapy and radiotherapy alone for patients with low-grade gliomas after surgical resection
... Dovepress gai et al with PCV + RT. On account of its easy administration and a favorable quality-of-life profile, 16 TMZ has been studied more extensively in recent years. A few trials have demon- strated its ...
5
Surgery Alone Versus Surgery Followed by Chemotherapy and Radiotherapy in Resected Extrahepatic Bile Duct Cancer: Treatment Outcome Analysis of 336 Patients
... Due to its rarity, conduct of randomized controlled trials for EHBDC is difficult [1,4]. Few randomized controlled tri- als evaluating adjuvant treatment have been reported, and most reports are retrospective ...
13
Effect of intensity-modulated radiotherapy versus two-dimensional conventional radiotherapy alone in nasopharyngeal carcinoma
... 2DCRT alone in a large scale cohort of NPC patients using propensity score matching and multivariate ...or radiotherapy boost was not specially evaluated herein, because it had been previously confirmed on ...
10