TRICARBOXYLIC ACID
Synthesis and Potent Antioxidant Activity of Benzene-1, 3, 5-Tricarboxylic Acid Derived Schiff Base Analogues
... toxic and highly active antioxidant compounds that demonstrate measurable health benefits. Based on the above facts and in continuation of our drug development program, the present work involves the synthesis of a new ...
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Nutritional Intervention with Tricarboxylic Acid Cycle Intermediates Modulates Mitochondrial Flux and Respiratory Chain Complex Abundance in C2C12 Myoblast Cells
... malic acid, when provided as single component additions, to the cells produced significantly lower extracellular lactate levels than glucose (p ≤ ...pyruvic acid was directly supplied to myocytes, indicated ...
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A Dysfunctional Tricarboxylic Acid Cycle Enhances Fitness of Staphylococcus epidermidis During β Lactam Stress
... ABSTRACT A recent controversial hypothesis suggested that the bactericidal action of antibiotics is due to the generation of en- dogenous reactive oxygen species (ROS), a process requiring the citric acid cycle ...
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Kinetic modeling of tricarboxylic acid cycle and glyoxylate bypass in Mycobacterium tuberculosis, and its application to assessment of drug targets
... the tricarboxylic acid (TCA) cycle and glyoxylate bypass, isocitrate dehydrogenase (ICD), involved in the TCA cycle, and ICL, involved in the glyox- ylate bypass, compete for the same substrate, namely ...
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Structural Basis for the Interaction of 14 3 3β with Tricarboxylic Acid Cycle Intermediate Malate
... a Tricarboxylic Acid Cycle in- termediate Malate bond model might offer a new approach to further analyze insulin-independent 14-3-3/ChREBP pathway of de novo fat synthesis in the ...
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Blocks in Tricarboxylic Acid Cycle of Salmonella enterica Cause Global Perturbation of Carbon Storage, Motility, and Host-Pathogen Interaction
... ABSTRACT The tricarboxylic acid (TCA) cycle is a central metabolic hub in most cells. Virulence functions of bacterial pathogens such as facultative intracellular Sal- monella enterica serovar Typhimurium ...
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An inherited defect affecting the tricarboxylic acid cycle in a patient with congenital lactic acidosis
... hydratase appeared normal. The binding of citrate to aconitate hydratase and the activities of the NAD- and NADP-linked isocitrate dehydrogenases were also normal, while the activity of citrate synthase was slightly ...
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Genetic Evidence for Two Carbon Fixation Pathways (the Calvin-Benson-Bassham Cycle and the Reverse Tricarboxylic Acid Cycle) in Symbiotic and Free-Living Bacteria
... algae, and many bacteria is the Calvin-Benson-Bassham (CBB) cycle. The six alternative pathways include among others the reverse tricarboxylic acid (rTCA) cycle and the recently discovered reversed ...
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Stochastic Variation in Expression of the Tricarboxylic Acid Cycle Produces Persister Cells
... energy levels. These cells showed considerably higher antibiotic tolerance after being sorted out from a growing population, showing that they are persisters. Importantly, dropping ATP to stationary-phase levels with ...
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Genetic and Biochemical Interactions Involving Tricarboxylic Acid Cycle (TCA) Function Using a Collection of Mutants Defective in All TCA Cycle Genes
... The eight enzymes of the tricarboxylic acid (TCA) cycle are encoded by at least 15 different nuclear genes in Saccharomyces cerevisiae. We have constructed a set of yeast strains defective in these genes as ...
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Monolayers of biphenyl 3,4',5 tricarboxylic acid formed on Cu and Ag from solution
... isophthalic acid moiety as a base unit on UPD-Cu ...isophthalic acid moiety enforces a characteristic row structure where the intrarow and interrow distances are determined by the periodicity of the ...
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Tricarboxylic acid cycle enzymes and bicarbonate fixation in morphogenesis of Blastocladiella emersonii.
... During the early period of exponential growth, RS plants, like OC plants, do not utilize glucose. Beginning at 24 hours and continuing for the next 24 hours, they consume 43 % of the total glucose, a value which ...
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Analysis of organic acids of tricarboxylic acid cycle in plants using GC-MS, and system modeling
... fumaric acid would occur) to the 12th cycle, was used to estimate the rate transfer coefficients of the difference equations (Table ...succinic acid, fumaric acid, and malic acid and the ...
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Rational modification of tricarboxylic acid cycle for improving l-lysine production in Corynebacterium glutamicum
... According to the above results, the sufficient biomass in the fermentation system is crucial to increase the l-lysine yield and productivity (Table 3 and Additional file 1: Table S5). As a growth-stimulating factor, ...
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Metabolic engineering of Bacillus amyloliquefaciens for enhanced production of S-adenosylmethionine by coupling of an engineered S-adenosylmethionine pathway and the tricarboxylic acid cycle
... Bacillus species, especially Bacillus subtilis, Bacillus amyloliquefaciens and Bacillus licheniformis, have been widely applied in the fields of medicine, food, cosmet- ics and agriculture [21, 22]. Due to the rapid ...
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A Lanthanide Luminescent Cation Exchange Material Derived from a Flexible Tricarboxylic Acid 2,6-Bis(1,2,3-triazol-4-yl)pyridine (btp) Tecton.
... 13. (a) Zou, J.-Y.; Gao, H.-L.; Shi, W.; Cui, J.-Z.; Cheng, P., "Auxiliary ligand-assisted structural diversities of three metal-organic frameworks with potassium 1H-1,2,3-triazole-4,5- dicarboxylic acid. ...
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Development and Characterization of a Condensed Reverse Tricarboxylic Acid Cycle for Use in Plants.
... amino acid metabolism, lipid metabolism, and a number of other metabolic processes, as well as activating ferredoxin-thioredoxin reductase (FTR) which has an important regulatory role for the CBB cycle and other ...
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THE EXCRETION OF l MALIC ACID IN RELATION TO THE TRICARBOXYLIC ACID CYCLE IN THE KIDNEY
... These observations on the several mechanisms of malic acid excretion in the kidney raise several important points about the nature of the phenomena themselves and their relation to the l[r] ...
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Roles of microRNA on cancer cell metabolism
... MicroRNAs (miRNAs) are endogenous ~22 nt RNAs that can play important regulatory roles in a variety of biological processes. They are genome-encoded, endogenous negative regulators of translation and mRNA stability ...
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