Triglyceride lipase
Association between skeletal muscle mass and serum concentrations of lipoprotein lipase, GPIHBP1, and hepatic triglyceride lipase in young Japanese men
... Background: Two important regulators for circulating lipid metabolisms are lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL). In relation to this, glycosylphosphatidylinositol anchored ...
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Original Article The expressions of pigment epithelium-derived factor and adipose triglyceride lipase in human kidney and correlation with renal lipid accumulation
... Adipose triglyceride lipase (ATGL, also called patatin-like phospholipase domain-containing protein 2) is the first identified receptor for PEDF [10], which has been demonstrated to catalyze the initial ...
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Effect of heparin induced lipolysis on the distribution of apolipoprotein e among lipoprotein subclasses Studies with patients deficient in hepatic triglyceride lipase and lipoprotein lipase
... hepatic lipase or of lipoprotein lipase and compared them with normal ...hepatic triglyceride lipase deficiency (n = 2) differ markedly from normal in that fraction II is the dominant apo ...
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Lipoprotein Metabolism during Acute Inhibition of Hepatic Triglyceride Lipase in the Cynomolgus Monkey
... hepatic triglyceride lipase was investigated in a primate model, the cynomolgus ...hepatic lipase fully inhibited cynomolgus monkey posttheparin plasma hepatic triglyceride lipase ...
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Inhibition of adipose triglyceride lipase (ATGL) by the putative tumor suppressor G0S2 or a small molecule inhibitor attenuates the growth of cancer cells
... adipose triglyceride lipase ...inhibits triglyceride catabolism and results in lower cell ...increased triglyceride levels, attenuated cell growth and promoted ...
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Loss of adipose triglyceride lipase is associated with human cancer and induces mouse pulmonary neoplasia
... In differentiated cells, potential alternative sources of fatty acids (FA) include the hydrolytic cleavage (lipolysis) of triglycerides (TG) stored in cytoplasmic lipid droplets [12]. Although adipose tissue is the most ...
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Effect of estrogen on post heparin lipolytic activity Selective decline in hepatic triglyceride lipase
... TG lipase and extrahepatic LPL were determined by two techniques: (a) separation by heparin-Sepharose column chromatography, and (b) selective inhibition with specific antibodies to post-heparin hepatic TG ...
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Berberine increases adipose triglyceride lipase in 3T3-L1 adipocytes through the AMPK pathway
... adipocytes and plays a crucial role in adipogenesis. HSL and ATGL are rate-limiting enzymes that regulate the lipolysis of TG in adipocytes [3]. They catalyze the hydrolysis of TG and effect different catabolism courses ...
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The role of adipose triglyceride lipase in lipid and glucose homeostasis: lessons from transgenic mice
... Consistent with increased hepatic steatosis there were also large increases in markers of liver damage, including plasma alanine aminotransferase and aspartate amino- transferase. Interestingly, liver-specific ATGL ...
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Maternal sodium butyrate supplement elevates the lipolysis in adipose tissue and leads to lipid accumulation in offspring liver of weaning-age rats
... adipose triglyceride lipase; CD36, fatty acid transfer proteins; CEBP β , CCAAT-enhancer binding proteins; CON, control; CPT-1A, Carnitine palmitoyltransferase 1A; CYP27A1, sterol 27-hydroxylase; FABP1, ...
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Intravenous injection of microvesicle-delivery miR-130b alleviates high-fat diet-induced obesity in C57BL/6 mice through translational repression of PPAR-γ
... tissue triglyceride lipase; ANOVA: Analysis of variance; BCA: Bicinchoninic acid; C/EBP- β : CCTTA enhancer binding protein- β ; DMEM/F-12: Dulbecco's modified eagle's medium: nutrient mixture F-12; FAS: ...
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Triglyceride deposit cardiomyovasculopathy: a rare cardiovascular disorder
... Triglyceride deposit cardiomyovasculopathy (TGCV) is a phenotype primarily reported in patients carrying genetic mutations in PNPLA2 encoding adipose triglyceride lipase (ATGL) which releases long ...
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Diet change and exercise enhance protein expression of CREB, CRTC 2 and lipolitic enzymes in adipocytes of obese mice
... Triacylglycerol (TAG) is hydrolyzed through the activ- ities of a trio of enzymes: adipose triglyceride lipase (ATGL), hormone sensitive lipase (HSL) and monoacyl- glycerol lipase (MGL) [5]. ...
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Lipases and lipid droplet-associated protein expression in subcutaneous white adipose tissue of cachectic patients with cancer
... ATGL: Adipose triglyceride lipase; BMI: Body mass index; CC: Cancer cachexia patients; CGI-58: Comparative gene identification-58; CRP: C-reactive protein; GAPDH: Glyceraldehyde 3-phosph[r] ...
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Docosahexaenoic acid increases accumulation of adipocyte triacylglycerol through up-regulation of lipogenic gene expression in pigs
... Adipose triglyceride lipase; C/ EBP α : CCAAT-enhancer binding protein α ; CGI58: Comparative gene identifcation 58; CPT1 α : Carnitine palmitoyltransferase 1 α ; DGAT1: Diacylglycerol acyltransferase 1; ...
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Dietary supplement of Smilax china L. ethanol extract alleviates the lipid accumulation by activating AMPK pathways in high-fat diet fed mice
... AMPK and sterol regulatory element binding proteins (SREBPs) are known to participate in adipogenesis. AMPK is a serine/threonine protein kinase that func- tions as a metabolic master switch [11]. It is expressed in a ...
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Exercise training improves intramuscular triglyceride lipolysis sensitivity in high-fat diet induced obese mice
... adipose triglyceride lipase (ATGL), which is the rate-limiting enzyme in TG hy- drolysis, and comparative gene identification-58 (CGI- 58, also known as ABHD5), a powerful activator of ATGL; although the ...
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Enzyme deficiency in cholesteryl ester storage disease
... Cholesteryl ester storage disease has been shown to involve severe deficiency of acid cholesteryl ester hydrolase and triglyceride lipase activity in liver, spleen, and lymph node.. The [r] ...
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Microarray analysis of gene expression profiles of tetrahymena H2B ubiquitylation mutant strains
... Accession Number Gene Description GO Molecular Function GO Biological Process GO Cellular Component TTHERM_00002660 Lipase family protein triglyceride lipase activity lipid metabolism un[r] ...
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Dietary fat clearance in normal subjects is regulated by genetic variation in apolipoprotein E
... The small particles Sf < 1,000 called the nonchylomicron fraction in normal people are cleared in proportion to postheparin hepatic triglyceride lipase levels and show delayed clearance [r] ...
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