trimethylamine N-oxide
Structural mechanism for bacterial oxidation of oceanic trimethylamine into trimethylamine N oxide
... Trimethylamine (TMA) and trimethylamine N-oxide (TMAO) are widespread in the ocean and are important nitrogen source for bacteria. TMA monoox- ygenase (Tmm), a bacterial flavin-containing ...
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Identification and characterization of trimethylamine N oxide (TMAO) demethylase and TMAO permease in Methylocella silvestris BL2
... This is the peer reviewed version of the following article Zhu, Yijun , Jameson, Eleanor, Parslow, Rosemary A., Lidbury, Ian, Fu, Tiantian, Dafforn, Timothy R., Schäfer, Hendrik and Chen, Yin. (2014) Identification and ...
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Resveratrol Attenuates Trimethylamine N Oxide (TMAO) Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota
... ABSTRACT The gut microbiota is found to be strongly associated with atherosclerosis (AS). Resveratrol (RSV) is a natural phy- toalexin with anti-AS effects; however, its mechanisms of action remain unclear. Therefore, we ...
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Microbiota dependent metabolite and cardiovascular disease marker trimethylamine N oxide (TMAO) is associated with monocyte activation but not platelet function in untreated HIV infection
... metabolite trimethylamine- N -oxide (TMAO) predicts myocardial infarction (MI) in the general population and has recently been shown to induce platelet ...
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Trimethylamine N-oxide, a gut microbiota-dependent metabolite of choline, is positively associated with the risk of primary liver cancer: a case-control study
... Trimethylamine N-oxide (TMAO) is a gut microbiota- dependent metabolite of choline that is formed in the liver by the hepatic enzyme flavin-containing monooxygenase-3 (FMO3) ...→ ...
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Order-disorder phase transition induced by proton transfer in a co-crystal of 2,4-dichlorobenzoic acid and trimethylamine N-oxide
... All reagents and solvents employed were commercially available and were used as supplied without further purification: 2,4-dichlorobenzoic acid and trimethylamine N- oxide (98%, Sigma-Aldrich). IR ...
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Intestinal Microbiota Composition Modulates Choline Bioavailability from Diet and Accumulation of the Proatherogenic Metabolite Trimethylamine N Oxide
... ABSTRACT Choline is a water-soluble nutrient essential for human life. Gut microbial metabolism of choline results in the pro- duction of trimethylamine (TMA), which upon absorption by the host is converted in the ...
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Fecal Aliquot Straw Technique (FAST) allows for easy and reproducible subsampling: assessing interpersonal variation in trimethylamine-N-oxide (TMAO) accumulation
... Background: Convenient, reproducible, and rapid preservation of unique biological specimens is pivotal to their use in microbiome analyses. As an increasing number of human studies incorporate the gut microbiome in their ...
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Trimethylamine N oxide metabolism by abundant marine heterotrophic bacteria
... Lidbury, Ian, Murrell, Colin J. and Chen, Yin. (2014) Trimethylamine N-oxide metabolism by abundant marine heterotrophic bacteria. Proceedings of the National Academy of Sciences of the United States ...
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O2 independent demethylation of trimethylamine N oxide by Tdm of Methylocella silvestris
... Bacterial trimethylamine N-oxide (TMAO) demethylase, Tdm, carries out an unusual oxygen-independent demethylation reaction, resulting in the formation of dimethylamine and ...
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Trimethylamine and trimethylamine N oxide are supplementary energy sources for a marine heterotrophic bacterium : implications for marine carbon and nitrogen cycling
... (2014) Trimethylamine and trimethylamine N-oxide are supplementary energy sources for a marine heterotrophic bacterium : implications for marine carbon and nitrogen ...
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Metabolic retroconversion of trimethylamine N-oxide and the gut microbiota
... choline, trimethylamine N-oxide (TMAO), phosphatidylcholine (PC), and carni- tine are present in a number of foodstuffs, including meat, fish, nuts, and ...with trimethylamine (TMA), ethanol, ...
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Genetics and molecular mechanism of trimethylamine N oxide demethylase of Methylocella silvestris BL2
... The identification of tdm and TMAO transporter gene (tmoP) in Methylocella silvestris BL2 (Aim 1) was sought in Chapter 3. Marker-exchange mutagenesis enabled the identification of several genes involved in TMAO ...
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Bacterial periplasmic nitrate and trimethylamine-N-oxide respiration coupled to menaquinol-cytochrome c reductase (Qcr): implications for electrogenic reduction of alternative electron acceptors.
... Although we have focussed on the clear phenotypes of the qcrABC mutant in relation to nitrate and TMAO reduction under oxygen-limited growth conditions, we also noted that this mutant gr[r] ...
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Facile Fluorescence Monitoring of Gut Microbial Metabolite Trimethylamine N-oxide via Molecular Recognition of Guanidinium-Modified Calixarene
... from Sigma-Aldrich Co., Ltd. (St. Louis, Missouri, USA). Fluorescein (Fl), 8-hydroxypyrene-1,3,6-trisul- fonate (HPTS), acridine orange (AO), 2-(p-toluidi- nyl)naphthalene-6-sulfonic acid (2,6-TNS), glutamic acid (Glu), ...
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The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer’s disease
... We identified 414 individuals in the Wisconsin Alzheimer’s Disease Research Center (ADRC) clinical core (n = 277) and the Wisconsin Registry for Alzheimer’s Prevention (WRAP) study (n = 137) who had ...
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Trimethylamine-N-oxide (TMAO)-induced atherosclerosis is associated with bile acid metabolism
... an atherogenic diet [1]. Recent clinical studies have suggested a correlation between elevated plasma tri- methylamine N-oxide (TMAO) levels and atheroscler- osis [2 – 5]. It has been shown that TMAO may ...
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Association of moderately elevated trimethylamine N-oxide with cardiovascular risk: is TMAO serving as a marker for hepatic insulin resistance
... In brief, if this analysis is accurate, various measures which alleviate hepatic insulin resistance–correction of visceral obesity, activation of 5' adenosine monophos- phate-activated[r] ...
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Quantification of glycine betaine, choline and trimethylamine N-oxide in seawater particulates: Minimisation of seawater associated ion suppression
... water in sample matrix) and increasing internal standard (ISTD) response. Tests were carried 534[r] ...
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Bacterial flavin containing monooxygenase is trimethylamine monooxygenase
... including trimethylamine (TMA) found in the diet of ...form trimethylamine N-oxide (TMAO), the TMA subsequently causing malodor in urine and the breath ...
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