triple-negative
Contribution of BRCA1 5382insC mutation in triple negative breast cancer in Tunisia
... on triple negative status and regardless of the age at onset and family history of ...with triple negative breast cancer were included in the present ...
5
Therapeutic potential of ERK5 targeting in triple negative breast cancer
... Triple negative breast cancers (TNBCs) account for 15% of all breast cancers, and represent one of the most aggressive forms of the disease, exhibiting short relapse-free ...
11
Rad51 supports triple negative breast cancer metastasis.
... In contrast to extensive studies on familial breast cancer, it is currently unclear whether defects in DNA double strand break (DSB) repair genes play a role in sporadic breast cancer development and progression. We ...
12
PRAME promotes epithelial to mesenchymal transition in triple negative breast cancer
... of triple negative breast cancer ...on triple negative breast cancer cell lines from the basal-like (MDA-MB-468) and mesenchymal (BT549) subtype, whereas the studies by Xiao J et ...
14
Immunotherapeutic interventions of Triple Negative Breast Cancer
... protumourigenic effect from Tregs may serve as poten- tial immunotherapies similar to adoptive cell therapy (ACT). Moreover, the contents of the extracellular matrix (ECM), such as MMPs, prevalently change their activ- ...
19
Clinicopathological, therapeutic and prognostic features of the triple negative tumors in moroccan breast cancer patients (experience of Hassan II university hospital in Fez)
... The Kaplan-Meier curves based showed the lowest survival probability at 3-years (49% of OS, and 39% of DFS). Conclusion: TNBC is associated with young age, high grade tumors, advanced stage at diagnosis, difference chemo ...
6
Original Article C-kit and PDGFRA gene mutations in triple negative breast cancer
... in triple negative breast cancer, is one of the hot therapeutic targets in the present ...the triple negative breast cancers were posi- tive for ...
6
Clinicopathlogic and Immunohistochemical Characteristics of Triple Negative Invasive Lobular Carcinoma
... of triple negative invasive lobular carcinoma (ILC), as has been demonstrated in their invasive ductal ...were triple negative carcinoma (TNC), which showed higher inci- dence of high ...
9
LncRNAs as new biomarkers to differentiate triple negative breast cancer from non-triple negative breast cancer
... Triple negative breast cancer (TNBC) is an aggressive type of breast cancer with high heterogeneity. To date, there is no efficient therapy for TNBC patients and the prognosis is poor. It is urgent to find ...
13
TAB3 O-GlcNAcylation promotes metastasis of triple negative breast cancer
... O-GlcNAcylation is a post-translational modification that regulates a broad range of nuclear and cytoplasmic proteins and is emerging as a key regulator of various biological processes. Although previous studies have ...
12
Clinical scenario of triple negative breast cancer at a tertiary care centre in southern rajasthan
... considered negative result. Patients with Estrogen receptor (ER) negative, Progesterone Receptor (PR) negative and HER- 2 negative were grouped as ...
6
A multigene predictor of metastatic outcome in early stage hormone receptor negative and triple negative breast cancer
... yielded negative Cox coefficients, indicating that for the majority of the HRneg/Tneg genes, higher transcript expression is asso- ciated with better prognosis (Table ...
15
Cripto-1 as a novel therapeutic target for triple negative breast cancer
... Triple-negative breast cancer (TNBC) presents the poorest prognosis among the breast cancer subtypes and no current standard therapy. Here, we performed an in-depth molecular analysis of a mouse model that ...
20
CYTOTOXICITY AND IN SILICO STUDIES OF ANETHOLE IN TRIPLE NEGATIVE BREAST CANCER CELLS
... INTRODUCTION: Triple-negative breast cancer is characterized by tumors that do not express estrogen receptor (ER), progesterone receptor (PR), or HER-2 genes and represents an important clinical challenge ...
6
Prognostic and predictive value of Ki-67 in triple-negative breast cancer
... Triple negative breast cancer (TNBC) is a subgroup of breast cancer lacking estrogen receptor (ER) and progesterone receptor (PR) expression as well as human epithelial growth factor receptor 2 (HER2) ...
9
Tumor suppressor role of microRNA-1296 in triple-negative breast cancer
... miR-1296 overexpression in TNBC cells significantly suppressed cell proliferation when compared to control miRNA expressing cells (Figure 2a-2b) as determined by the Cell Counting Kit. Overexpression of miR-1296 in TNBC ...
12
Profiling molecular regulators of recurrence in chemorefractory triple negative breast cancers
... tant triple-negative or BRCA1/2-mutated hormone re- ceptor (HR)-positive breast cancer ...were negative, and hereditary BRCA1/2 mutation status did not improve DFS ...
15
CIP2A is a target of bortezomib in human triple negative breast cancer cells
... Paraffin-embedded tissue microarray of tumor samples from TNBC patients’ sections (4-μm) on poly-1-lysine- coated slides were first de-waxed in xylene and re- hydrated through graded alcohols, followed by a rinse using ...
14
Epigenetic hypomethylation and upregulation of GD3s in triple negative breast cancer
... to block endogenous peroxidase at room temperature. The GD3s antibody was added to the slides, which were incubated overnight at 4 ℃, followed by 1 h incubation with biotinylated second Ab. Staining was done with ...
15
Molecular subtypes and precision treatment of triple negative breast cancer
... plus paclitaxel and 12.6 months with placebo plus paclitaxel. In patients with PIK3CA/AKT1/PTEN-altered tumors, an improvement in PFS was observed from 3.7 to 9.3 months with the addition of capivasertib to paclitaxel ...
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