Triple-negative breast cancers
Clinicopathological Study of Triple Negative Breast Cancers
... Introduction: Triple Negative Breast Cancers (TNBC) are a subset of breast cancers which are composed of different molecular ...
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Immunohistochemical Profile and Morphology in Triple – Negative Breast Cancers
... the triple-negative breast cancer correlated significantly with a younger age at diagnosis and a higher histol ogical grade, which correlated with the results which were ob tained by Dent et al 2007, ...
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Clinicopathologic features of triple negative breast cancers: an experience from Pakistan
... of triple negative cancers in Caucasians, Australians and UK population was found to be low with a frequency of ...like breast cancers lies with its association with BRCA 1 ...80% ...
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CDCP1 is a novel marker of the most aggressive human triple- negative breast cancers
... human triple- negative breast cancers Federica Turdo 1,* , Francesca Bianchi 1,7,* , Patrizia Gasparini 2 , Marco Sandri 1 , Marianna Sasso 1 , Loris De Cecco 3 , Luca Forte 1 , Patrizia ...
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FOXA1 is Prognostic of Triple Negative Breast Cancers by Transcriptionally Suppressing SOD2 and IL6
... for breast cancer subtyping, especially for triple negative breast cancer identification is crucial for improving the treatment outcome of such ...characterizing triple negative ...
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Epigenetic silencing of CREB3L1 by DNA methylation is associated with high grade metastatic breast cancers with poor prognosis and is prevalent in triple negative breast cancers
... metastatic breast cancer cell lines is caused in part by epigenetic ...metastatic breast cancer cell lines that had low CREB3L1 expression with DNA methyltransferase and histone deacetylase inhibitors ...
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Homogeneous datasets of triple negative breast cancers enable the identification of novel prognostic and predictive signatures
... 73.9% in finding and validation cohort, respectively). Regarding histological grading the proportion of grade 3 tumors is 73.5% and 74.1% in finding and validation cohort, respectively (Table S7). These numbers are ...
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Classification of triple-negative breast cancers based on Immunogenomic profiling
... Immunity_H had stronger immune cell infiltration and anti-tumor immune activities, e.g., high levels of cyto- toxic T cells and B cells infiltration (Fig. 1). When we used CIBERSORT [28] to calculate the proportions of ...
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Profiling molecular regulators of recurrence in chemorefractory triple negative breast cancers
... of breast can- cer, no targeted therapies exist for these ...aggressive cancers with a high risk-of-recurrence and de- veloping tailored therapies for their treatment signifies a critical frontier in the ...
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Targeting MET and EGFR crosstalk signaling in triple-negative breast cancers
... This molecular heterogeneity increases the difficulty of developing targeted therapeutics that will be effective in the majority of TNBC patients. Chemotherapy is currently the only systemic therapy available for TNBC ...
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BRCA1 IRIS inactivation overcomes paclitaxel resistance in triple negative breast cancers
... The specificity of BRCA1-IRIS-overexpression-induced acquired paclitaxel resistance is shown here by genetic manipulation of BRCA1-IRIS in three aggressive TNBC lines. In addition, we achieved sensitization to lower con- ...
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HPV infection and triple negative breast cancers: an Italian case control study
... Background: Breast cancer is one of the most important neoplasia among ...different breast cancer types has been demonstrated until ...the triple-negative breast cancer (TNBC), ...
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Spatially distinct tumor immune microenvironments stratify triple negative breast cancers
... a negative feedback loop between the IFN and cholesterol biosynthesis pathways, the combination of “IFN/cholesterol” metasignatures (epiMSigs 2 and 5) more accurately predicted SR and FI subtypes in our cohort and ...
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Evaluation of the prognostic value of tumor-infiltrating lymphocytes in triple-negative breast cancers
... reduction of risk of death (P = 0.002) were observed. Multivariate analysis confirmed sTILs to be an independent prognostic marker. 3.5% of TNBCs had more than 50% lymphocytes (lymphocyte-predominant breast ...
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Triple Negative Breast Cancers Have a Reduced Expression of DNA Repair Genes
... RNA and real time RNA was extracted from core biopses with the High Pure FFPE RNA Micro Kit (Roche). RNA concentrations were then measured by NanoDrop spectrophotometer and retro-transcrip- tion to cDNA was performed ...
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CDCP1 is a novel marker of the most aggressive human triple-negative breast cancers
... epithelial cancers, was found to be expressed in highly aggressive triple-negative breast cancer (TNBC) cell models, in which it promoted aggressive activities—ie, migration, invasion, ...
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Towards the development of HAGE-based vaccines for the treatment of patients with triple negative breast cancers
... 6.1.3. Pre-clinical image-based evaluation of cancers The proficiency of pre-clinical studies relies on the choice of appropriate animal models. It is crucial to have a fully functional immune system that is ...
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MCP-1 is overexpressed in triple-negative breast cancers and drives cancer invasiveness and metastasis.
... 485 Breast Cancer Research and Treatment (2018) 170:477–486 1 3 autocrine manner ...in breast cancer cells ...in breast cancer cells [ 22 ] Thus, a positive feedback loop may be able to ...
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Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers
... Acknowledgements The authors would like to acknowledge the Center for Translational Genomics, Lund University and Clinical Genomics Lund, SciLifeLab for support with DNA methylation analyses, patients and clinicians ...
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Triple negative breast cancers are increased in black women regardless of age or body mass index
... of breast can- cers in a patient population unusual for its racial/ethnic and socioeconomic ...on triple-negative ...of triple-negative tumours in black women, who comprised 43% of our ...
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