Trk receptor
Neurotrophin/Trk receptor signaling mediates C/EBPα, -β and NeuroD recruitment to immediate-early gene promoters in neuronal cells and requires C/EBPs to induce immediate-early gene transcription
... of Trk signaling in ...of Trk signaling during devel- opment (through disruption of Ntrk2 and Ntrk3 alleles; supplemental Figure 4 in Additional data file 1, and pre- vious work in which we have shown that ...
22
Arsenic trioxide induces cell cycle arrest and affects Trk receptor expression in human neuroblastoma SK-N-SH cells
... the Trk family at different stages is clearly related to the prognosis and outcome of NB patients ...the Trk family of neurotrophin receptors, which includes TrkA, TrkB and TrkC, plays a prominent role in ...
9
The single AmphiTrk receptor highlights increased complexity of neurotrophin signalling in vertebrates and suggests an early role in developing sensory neuroepidermal cells
... loose Trk-binding ability to the distinct ...a Trk receptor, because this pathway is believed to drive the most complex responses generated by Trk-Nt interactions in mammalians (Koponen et ...
12
Trk signaling regulates neural precursor cell proliferation and differentiation during cortical development
... (C-F) Trk receptor signaling is necessary for appropriate embryonic ...(G-I) Trk receptors collaborate to regulate precursor proliferation and ...
12
Evaluation of Tyrosine Kinase receptor (TrK) Expression in Follicular and Plexiform types of Ameloblastoma: An Immunohistochemical study
... of Trk-kinase receptors by their cognate ligands initiates a cascade of signaling events which leads to either mitogenic stimuli for malignant transformation or neuronal ...differentiation. Trk receptors ...
86
Basket trial of TRK inhibitors demonstrates efficacy in TRK fusion-positive cancers
... tropomyosin receptor kinases (TRK), TRKA, TRKB, and TRKC, respectively, are receptor tyrosine kinases that are normally expressed in the nervous system ...Physiologically, TRK receptor ...
5
Developmental potential of defined neural progenitors derived from mouse embryonic stem cells
... and Trk receptors, donor neurons in the DRG did not express detectable levels of Trk ...of Trk receptors may account for their failure to elongate ...of Trk receptor (Wright and Snider, ...
8
Modulation of neurotrophic signaling pathways by polyphenols
... of Trk receptors and mimic the binding of neurotrophins, while several others stimulate the more downstream pathways leading to the neurotrophic effect (discussed in the following ...a Trk receptor ...
20
Insights into Current Tropomyosin Receptor Kinase (TRK) inhibitors: development and clinical application
... of TRK receptor tyrosine kinases and major signal transduction pathways involved in cell differentiation, proliferation, and ...factor receptor-bound protein 2; SHC, SRC homology 2 domain containing; ...
63
Expression of brain-derived neurotrophic factor in kidneys from normal and cyclosporine-treated rats
... and Trk receptor expression in this model may be direct or ...and Trk receptor expression in cul- tured SH-SY5Y cells in the hippocampus and midbrain, and that this may be related to the ...
12
Regulation and Kinase Activity of the Trk Family of Receptor Tyrosine Kinases
... RTKs are well known to signal as dimers, with extracellular ligand binding inducing either dimerization or the transition from an inactive dimeric form to an active dimer (Lemmon and Schlessinger, 2010). Accordingly, ...
164
The Role of Brain-Derived Neurotrophic Factor in the Pathophysiology of Psychiatric and Neurological Disorders
... form, and the tropomyosin receptor kinase B (TrkB), which binds to its mature form. Activation of TrkB and p75NTR may produce opposite outcomes in that TrkB receptors have a well-defined trophic role and their ...
18
The trk family of receptors mediates nerve growth factor and neurotrophin 3 effects in melanocytes
... NGF receptor, also induces trk in melanocytes, and TPA effect is further potentiated by the presence of keratinocytes in ...Moreover, trk in melanocytes becomes phosphorylated within minutes after ...
14
Small fibre function tests in diabetic poly neuropathy
... c) Alternatively diabetic neuropathy may be the result of reduced/down-regulation of axonal transport mechanisms. In this case reduced delivery of tyrosine kinase A (trk-A) high-affinity receptors to the ...
164
Trk inhibition reduces cell proliferation and potentiates the effects of chemotherapeutic agents in Ewing sarcoma
... Some studies have shown that tumor cells treated with BDNF are less sensitive to cytotoxic drugs [26, 45]. Moreover, neurotrophin signaling pathways may function as endogenous systems that protect neurons after ...
21
The effect of 3,4- methylenedioxymethamphetamine on expression of neurotrophic factors in hippocampus of male rats
... Several studies have demonstrated that MDMA admin- istration can modulate BDNF, however, less is known about the changes in the NT-4 and Trk- β expression. Schaaf et al. found that BDNF expression reduces after ...
5
Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents
... LM22A compounds function through TrkB. (A) Survival analysis of hippocampal neurons treated with BDNF (0.7 nM) or LM22A compounds (500 nM) with or without the Trk inhibitor K252a (200 nM). For BDNF, n = 37 wells ...
13
Retinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistance
... TGF-β receptor (type III) is reduced in high-stage neuroblastoma, while increased TGF- β receptor (type II) expression suppresses malignant neuroblastoma pheno- types and induces differentiation [121, ...
22
More expressions of BDNF and TrkB in multiple hepatocellular carcinoma and anti-BDNF or K252a induced apoptosis, supressed invasion of HepG2 and HCCLM3 cells
... of Trk by tyrosine kinase inhibitors was correlated with more apoptotic [30], or less invasive tumor cells [31], and aiming at interfering TrkB activation might be helpful in the development of effective ...
8
Nerve growth factor and receptor expression in rheumatoid arthritis and spondyloarthritis
... Taken together, this comprehensive analysis demonstrates the expression of the pleiotropic NGF and its two receptors in peripheral synovitis of SpA and RA. The knowledge of neuro- trophin expression on cells from the ...
9