trophoblast invasion
Dipeptidyl peptidase IV reduces trophoblast invasion by inhibiting the activity of MMPs
... It has been shown that DPPIV suppresses the growth and progression of many cancer cells (Wes- ley et al., 2004) but also found overexpressed in type II diabetes, chronic liver diseases, and various malignant tumors (Itou ...
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The m6A demethylase ALKBH5 controls trophoblast invasion at the maternal-fetal interface by regulating the stability of CYR61 mRNA
... of trophoblast invasion, we transfected HTR-8 cells with siALKBH5 oligos for 48 ...in trophoblast from the ALKBH5 overexpression group (Figure ...
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Critical growth factors and signalling pathways controlling human trophoblast invasion
... established trophoblast cell lines derived from first trimester placentae which are commonly used to study trophoblast ...blast invasion in the above mentioned cell lines, several other putative EVT ...
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Urothelial carcinoma associated 1 promotes trophoblast invasion by regulating MMP9
... and invasion of trophoblasts, which further results in the progression of the RM diseases ...of trophoblast invasion at early ...the invasion of trophoblasts are correlated with complicated ...
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Expression and importance of matrix metalloproteinase 2 and 9 (MMP-2 and -9) in human trophoblast invasion
... of trophoblast invasion is mediated in an auto-and para- crinic way by trophoblastic and uterine factors ...[2,3]. Trophoblast invasion is facili- tated by degradation of the extracellular ...
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Human trophoblast invasion: new and unexpected routes and functions
... recently, trophoblast invasion during human placentation was characterized by and restricted to invasion into uterine connective tissues and the uterine spiral ...changed. Invasion of ...
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Original Article Expression of uPAR in human trophoblast and its role in trophoblast invasion
... migration, invasion angiogenesis, and the malignant phe- notype of cancer [15, ...mediates trophoblast invasion and plays a significant role in angiogenesis during early macaque implan- tation ...in ...
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Altered expression of norepinephrine transporter and norepinephrine in human placenta cause pre-eclampsia through regulated trophoblast invasion
... uptake, invasion activity, and a chan- ge in immune response, may occur during placentation, leading to the development of ...increased invasion activity at a relevant ...[21-32]. Trophoblast cells ...
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TROPHOBLAST INVASION AND UTERIOIMPLANTATION GROWTH IN EARLY RAT GESTATION REQUISITE ADRENOMEDULLIN
... Placental apoptosis is increased in vivo in preeclampsia (PE) and intrauterine growth restriction (IUGR). The cause and pathological implications of this phenomenon were unknown previously. Our current study was ...
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HIF2α in the uterine stroma permits embryo invasion and luminal epithelium detachment
... tation sites collected by laser capture microdissection (LCM) was downregulated in Hif2a-uKO mice compared with the con- trols (Figure 7, C and D). We also confirmed the downregulation of these genes by in situ ...
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Effects of Oncostatin M on Invasion of Primary Trophoblasts under Normoxia and Hypoxia Conditions
... the OSM-induced enzymatic activities of MMP-2 and MMP-9 are increased under a low oxygen environment. OSM might be able to increase the invasiveness of term EVTs under low oxy- gen content. This might lead to failure of ...
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S100P enhances the motility and invasion of human trophoblast cell lines
... cellular invasion in different trophoblastic and first trimester EVT cell ...cell invasion was seen to be more dramatically affected than cell ...of trophoblast invasion during ...
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Adrenomedullin: A Novel Vasoregulatory Peptide Hormone Enhances Invasion of Trophoblast on Uterine Endometrium The First Trimester Human Trophoblast ACH 3P Cell Line on Early Pregnancy
... and invasion play fundamental roles in the process of embryo implantation and ...the trophoblast invasion into the uterine endometrium is important for placentation ...EVCT invasion peaks at ...
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Original Article Osteopontin regulates trophoblast proliferation and invasion and associates with spontaneous abortion during early pregnancy
... Abstract: Trophoblast proliferation and invasion are the hall marks of early placental development, defects in tro- phoblast proliferation and invasion may lead to early pregnancy ...choriocarcinoma ...
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Original Article MiR-223 promotes trophoblast cell survival and invasion by targeting STAT3 in preeclampsia
... extravillous trophoblast [4, ...of trophoblast is appearing to limit the invasiveness of trophoblast cells into the uterine wall [6, ...less trophoblast invasion is closely related to ...
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Adenosine A2Breceptors induce proliferation, invasion and activation of cAMP response element binding protein (CREB) in trophoblast cells
... sion of HTR-8/SVneo for 24 h, but inhibited after 72 h [45]. Since different assays were used to determine the ef- fects of hypoxia on trophoblast invasion these results are hard to compare. The co-culture ...
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Original Article CUL4A is expressed in human placenta and involved in trophoblast cell invasion
... in trophoblast cell invasion and ...(when trophoblast cells exert high inva- ...ter trophoblast cell origin, and JAR and JEG-3 cells of choriocarcinoma ...in trophoblast invasion ...
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Original Article Proteomic analysis of knock-down HLA-G in invasion of human trophoblast cell line JEG-3
... in trophoblast cells plays important roles in trophoblast invasion; however, the mechanisms remain to be ...with invasion, cell cycle and cell metabolism, ...and trophoblast ...
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H19 long noncoding RNA alters trophoblast cell migration and invasion by regulating TβR3 in placentae with fetal growth restriction
... and invasion of extravillous trophoblast (EVT) cells in ...reduced trophoblast invasion that has been observed in ...and invasion, owing to impaired TGF-β signaling through a ...
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Original Article CUL4A enhances human trophoblast migration and is associated with pre-eclampsia
... trophoblast invasion. However, the role of CUL4A in other trophoblast behavior such as migration and the association with pregnancy disorder remains ...inadequate trophoblast migration re- ...
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