trypanosoma brucei
Characterisation of potential Holliday junction resolvases in Trypanosoma brucei
... parasite. Trypanosoma brucei (T. brucei), which is the focus of this work, is the cause of two diseases, Human African Trypanosomiasis (HAT) and ...T. brucei, the parasites remain resilient to ...
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Regulation of the Cell Division Cycle in Trypanosoma brucei
... Regulation of DNA replication in Trypanosoma brucei appears to be different from that in other eukaryotes. It was previously thought that trypanosomes expressed a single Orc1/Cdc6-like protein. This ...
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TrypanoCyc: a community led biochemical pathways database for Trypanosoma brucei
... Trypanosoma brucei is the causative agent of African try- panosomiasis (commonly known as sleeping sickness in hu- mans and Nagana in animals). The disease is fatal if un- treated in humans (1) and the ...
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Non natural acetogenin analogues as potent Trypanosoma brucei inhibitors
... prevalent Neglected tropical diseases which has been slowly attracting attention over the past few years is African sleeping sickness or Human African Trypanosomiasis (HAT), caused by the protozoan parasite ...
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Mating compatibility in the parasitic protist Trypanosoma brucei
... Background: Genetic exchange has been described in several kinetoplastid parasites, but the most well-studied mating system is that of Trypanosoma brucei, the causative organism of African sleeping ...
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Metabolic reprogramming during the Trypanosoma brucei life cycle
... Figure 1. Changes in metabolism during the life cycle of Trypanosoma brucei. T. brucei life cycle spans two hosts: a mammal (human, cattle, wild animals) and the tsetse fly. As this protozoan ...
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Lipidomic analysis of bloodstream and procyclic form Trypanosoma brucei
... of Trypanosoma brucei contain a complex array of phospholipids that are synthesized de novo from precursors obtained either directly from the host, or as catabolised endocytosed ...
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Nanomolar Inhibitors of Trypanosoma brucei RNA Triphosphatase
... ABSTRACT Eukaryal taxa differ with respect to the structure and mechanism of the RNA triphosphatase (RTPase) component of the mRNA capping apparatus. Protozoa, fungi, and certain DNA viruses have a metal-dependent RTPase ...
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Identification and Specific Localization of Tyrosine-Phosphorylated Proteins in Trypanosoma brucei
... of Trypanosoma brucei (29; ...T. brucei causes human African trypanosomiasis (also known as African sleeping sickness) and is responsible for ⬃ 30,000 deaths per annum ...
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Tracking autophagy during proliferation and differentiation of Trypanosoma brucei
... [11–14]. Trypanosoma brucei is a parasitic protozoon, transmitted by the tsetse fly, which causes Human and Animal African Trypanosomiasis (HAT and ...T. brucei genome contains identifiable genes ...
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TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei
... Trypanosoma brucei is the causative agent of African try- panosomiasis (commonly known as sleeping sickness in hu- mans and Nagana in animals). The disease is fatal if un- treated in humans (1) and the ...
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The Trypanosomal Transferrin Receptor of Trypanosoma Brucei—A Review
... Received: 9 September 2019; Accepted: 25 September 2019; Published: 1 October 2019 Abstract: Iron is an essential element for life. Its uptake and utility requires a careful balancing with its toxic capacity, with ...
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In vitro activity of salinomycin and monensin derivatives against Trypanosoma brucei
... Background: African trypanosomes are the causative agents of sleeping sickness in humans and nagana disease in livestock animals. As the few drugs available for treatment of the diseases have limited efficacy and produce ...
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Dynamics of gamete production and mating in the parasitic protist Trypanosoma brucei
... Background: Sexual reproduction in Plasmodium falciparum and Trypanosoma brucei occurs in the insect vector and is important in generating hybrid strains with different combinations of parental ...
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Mosaic VSGs and the Scale of Trypanosoma brucei Antigenic Variation
... prolonged Trypanosoma brucei infection and transmission and success of the parasite is the interplay between host acquired immunity and antigenic variation of the parasite variant surface glycoprotein (VSG) ...
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In Vitro Generation of Human High-Density-Lipoprotein-Resistant Trypanosoma brucei brucei
... to Trypanosoma brucei brucei but not the human sleeping sickness parasite Trypanosoma brucei ...b. brucei-like ancestor and expresses a defense protein that ablates the ...
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TrypanoCyc : a community led biochemical pathways database for Trypanosoma brucei
... Trypanosoma brucei is the causative agent of African try- panosomiasis (commonly known as sleeping sickness in hu- mans and Nagana in animals). The disease is fatal if un- treated in humans (1) and the ...
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A Trk/HKT-Type K+ Transporter from Trypanosoma brucei
... Trypanosoma brucei subsp. parasites comprise the causative agents of human and livestock trypanosomosis: sleeping sick- ness and nagana, respectively. The distribution of the parasites is restricted by that ...
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An evaluation of minor groove binders as anti-Trypanosoma brucei brucei therapeutics
... In conjunction with our commercial partner, MGB Biopharma, we have had great success in developing our MGBs as antibacterials [18] and, crucially, structural features of these MGBs are quite distinct from the diamidines. ...
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Proline Metabolism is Essential for Trypanosoma brucei brucei Survival in the Tsetse Vector
... all Trypanosoma brucei ...b. brucei uses L-proline as its main carbon source, relying on an efficient catabolic pathway to convert it to glutamate, and then to succinate, acetate and ala- nine as the ...
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