Trypanosoma cruzi
Implications of genetic variability of Trypanosoma cruzi for the pathogenesis of Chagas disease
... O Trypanosoma cruzi, agente etiológico da doença de Chagas, apresenta elevado grau de variabilidade ge- nética intra-específica, com possíveis implicações na forma clínica da doença, como o desenvolvimento ...
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Uptake of l-Alanine and Its Distinct Roles in the Bioenergetics of Trypanosoma cruzi
... disease, Trypanosoma cruzi, produce alanine as a main end product of their energy metabolism when they grow in a medium containing glucose and amino ac- ...
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Pharmacophore modeling and 3D QSAR studies on Chalcones as Trypanosoma cruzi inhibitors
... the Trypanosoma cruzi inhibitory activity can be gained by visualizing the 3D-QSAR model in the context of one or more ligands in the series with varying ...
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Oxidative stress fuels Trypanosoma cruzi infection in mice
... including the expression of heme-oxygenase–1 (HO-1). Unexpectedly, the activation of NRF2 and HO-1 reduces infection by a number of pathogens, although the mechanism responsible for this effect is largely unknown. We ...
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Inhibition of HSP90 in Trypanosoma cruzi Induces a Stress Response but No Stage Differentiation
... parasite Trypanosoma cruzi is a human pathogen with considerable impact on the health of millions in the Americas ...T. cruzi proliferates in the lumens of the guts of reduviid ...T. cruzi can ...
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Comparison of PCR and microscopic methods for detecting Trypanosoma cruzi
... with Trypanosoma cruzi, the protozoan parasite that causes Chagas’ disease, is generally made by detecting parasites by microscopic examination of fresh ...T. cruzi were described, but the ...
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A darker chromatic variation of Rhodnius pallescens infected by specific genetic groups of Trypanosoma rangeli and Trypanosoma cruzi from Panama
... infections. Trypanosoma rangeli and T. cruzi infec- tions were genotyped by PCR/RFLP-cox2 and confirmed by sequencing PCR-cox2 ...amplicons. Trypanosoma cruzi lineage I (TcI) was the single T. ...
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Dispersal Patterns And Reproductive Strategies Of Trypanosoma Cruzi In An Urban Environment
... of Trypanosoma cruzi – a protozoan parasite and causative agent of Chagas disease in humans – in the city of Arequipa in southern ...T. cruzi genomes collected throughout Arequipa (N=123) and South ...
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Detection of Trypanosoma cruzi and Trypanosoma rangeli Infection by Duplex PCR Assay Based on Telomeric Sequences
... Trypanosoma cruzi causes Chagas’ disease, a fatal illness endemic to many Latin American ...T. cruzi shares reservoirs and vectors with the related protozoan Trypanosoma rangeli, which is ...
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Seropositivity for Trypanosoma cruzi in domestic dogs from Sonora, Mexico
... Trypanosoma cruzi epidemiology studies in domestic dogs have been performed in seven states of Mexico (see Table 1) and a direct correlation of seropositivity between humans and dogs has been ...T. ...
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Bioluminescent imaging of Trypanosoma cruzi infection in Rhodnius prolixus
... Expression of firefly luciferase (Fluc) in Trypanosoma cruzi The luciferase gene was amplified by PCR using specific primers. The forward primer contains an XbaI site and the Kozak sequence (underlined), ...
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Trypanosoma dionisii as an experimental model to study anti-Trypanosoma cruzi drugs: A comparative analysis with benznidazole, posaconazole and amiodarone
... T. cruzi, using amiodarone or posaconazole, we note that there is a reduction of about 10 ...cholesterol. Trypanosoma cruzi depends on de-novo ergosterol production for its survival in all the stages ...
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Different serological cross reactivity of Trypanosoma rangeli forms in Trypanosoma cruzi infected patients sera
... of Trypanosoma cruzi (Y strain) and Trypanosoma rangeli (Choachi strain) with chagasic ...T. cruzi (dark arrows) or on ...T. cruzi-infected patients. Lanes 1 and 2 = T. cruzi Y ...
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Evaluation of the Anti Trypanosoma Cruzi Effects of the Antipsychotic Drug Levomepromazine
... Trypanosoma cruzi, the causative agent for Chagas dis- ease, a relevant health problem in most American coun- tries, as it is broadly distributed from Mexico to southern Argentina and Chile, where it is ...
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Geographical, landscape and host associations of Trypanosoma cruzi DTUs and lineages
... published). Trypanosoma cruzi is a diploid organism having clonal structure [7–9], strong linkage disequilib- rium, and an absence of segregated and recombining genotypes ...T. cruzi I and T. ...
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New Trypanosoma cruzi Repeated Element That Shows Site Specificity for Insertion
... A new family of site-specific repeated elements identified in Trypanosoma cruzi, which we named TcTREZO, is described here. TcTREZO appears to be a composite repeated element, since three subregions may be ...
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Wide distribution of Trypanosoma cruzi infected triatomines in the State of Bahia, Brazil
... Trypanosoma cruzi has been detected in vectors in all regions of ...respectively. Trypanosoma cruzi infections in triatomines based on parasite morphology after optical microscopy are ...
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A reduction in ecological niche for Trypanosoma cruzi infected triatomine bugs
... of Trypanosoma cruzi, the causal agent of Chagas ...control. Trypanosoma cruzi is a typical parasite with a complex life-cycle; it requires bugs to carry and transfer it to humans and other ...
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Discovery of novel and potent benzhydryl-tropane trypanocides highly selective for Trypanosoma cruzi
... Abstract — A benzhydryl tropinone oxime that is potently toxic to Trypanosoma cruzi has been previously identified. An SAR investigation determined that no part of the original compound was superfluous and ...
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Trypanosoma cruzi load in synanthropic rodents from rural areas in Chile
... T. cruzi in rodents ’ blood revealed that their levels of parasitemia were similar to those found in ...HIV/T. cruzi co-infection patients with Chagas disease reactivation (median value: 1428 parasites/ ml) ...
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