TSST-1
Targeting of Hepatoma Cell and Suppression of Tumor Growth by a Novel 12mer Peptide Fused to Superantigen TSST-1
... the TSST-1 SAg, the resulting fusion pro- tein could bind to hepatoma cells with high affinity in vitro and improved the tumor inhibition effect by activating T lymphocyte cells in vitro and in vivo, ...
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Prevalence of Toxic Shock Syndrome Toxin 1 (TSST 1) Producing Strains of Staphylococcus aureus and Antibody to TSST 1 among Healthy Japanese Women
... for TSST-1 in Japan was not a result of lack of colonization by ...by TSST-1-producing strains: 52% of women were colonized with ...produced TSST-1, and 6% of women were ...
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Influence of Subinhibitory Concentrations of Honey on Toxic Shock Syndrome Toxin 1 (TSST 1) Production by Two Strains of Staphylococcus Aureus
... measured in this study varied between different honeys ranging from low (Capstone Valley blossom honey) to high (Buckwheat honey). Polyphenols are a vast group of molecules based on phenol, a well known antimicrobial ...
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The Prevalence of Toxin Shock Syndrome oxin ( TSST-1) Producing Clinical Isolates of Staphylococcus aureus StrainsIsolated from Shohada Hospital in Tabriz, Iran
... 15. Parsonnet J, Goering R, Hansmann M, Jones M, Ohtagaki K, Davis C , Totsuka K. Prevalence of Toxic Shock Syndrome Toxin 1 (TSST-1)-Producing Strains of Staphylococcus aureus and Antibody to ...
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Specific Inhibitory Action of Anisodamine against a Staphylococcal Superantigenic Toxin, Toxic Shock Syndrome Toxin 1 (TSST-1), Leading to Down-Regulation of Cytokine Production and Blocking of TSST-1 Toxicity in Mice
... TSST-1 binds directly to the major histocompatibility com- plex (MHC) class II molecules on antigen-presenting cells (APCs) and to the V  elements of antigen receptors of T cells. This trimolecular ...
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Immunopathophysiological aspects of an emerging neonatal infectious disease induced by a bacterial superantigen
... of TSST-1 and pro- tecting against the development of NTED, as shown in Figure 3 and discussed ...attenuated TSST-1 may be one means of preventing the development of NTED in their ...whether ...
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Oxygen and Carbon Dioxide Regulation of Toxic Shock Syndrome Toxin 1 Production by Staphylococcus aureus MN8
... resuspended by agitation in 3 ml of Todd-Hewitt broth (Difco Laboratories, Detroit, Mich.). Two milliliters of this suspension was immediately treated with 8 ml (4 volumes) of ethanol, and the mixture was incubated at ...
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Detection and quantitation of toxic shock syndrome toxin 1 in vitro and in vivo by noncompetitive enzyme linked immunosorbent assay
... Of 60 isolates negative for TSST-1 production as tested by immunodiffusion, 42 would be falsely positive by ELISA if culture supernatants were not pretreated with 10% normal rabbit serum[r] ...
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The effect of Staphylococcus aureus carriage in late pregnancy on antibody levels to staphylococcal toxins in cord blood and breast milk
... or TSST-1 at 1 mg mL 1 in carbonate ...mL 1 . Plates were incubated overnight at 4 1 C and then washed four ...for 1 h at 37 1 ...for 1 h at 37 1 ...
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Production and characterization of monoclonal antibodies to toxic shock syndrome toxin 1 and use of a monoclonal antibody in a rapid, one step enzyme linked immunosorbent assay for detection of picogram quantities of toxic shock syndrome toxin 1
... Twenty-six hybridoma cell lines that produced monoclonal antibodies to toxic shock syndrome toxin 1 TSST-1 were generated by immunizing mice with a highly purified preparation of TSST-1 [r] ...
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Role of IL 12 in Staphylococcus aureus triggered arthritis and sepsis
... Despite eradication of bacteria from the joint cavity destruc- tion of the joint often continues, resulting in severe sequelae [9]. Several efforts have been made to down-modulate the inflammatory responses that lead to ...
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Persistence survey of Toxic Shock Syndrome toxin 1 producing Staphylococcus aureusand serum antibodies to this superantigen in five groups of menstruating women
... aureus TSST-1 in a susceptible host [8,9]. TSST-1 is considered a superantigen (SAg), a class of very potent immune stimulators that interact with the immune sys- tem in a way that is ...
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Clindamycin suppresses virulence expression in inducible clindamycin-resistant Staphylococcus aureus strains
... Staphylococcus aureus produces many virulence factors that play an important role in the pathogenesis of infec- tion, such as Hla [12], PVL [13, 14] and TSST-1 [15]. Several studies have shown that ...
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Differential arthritogenicity of Staphylococcus aureusstrains isolated from biological samples
... 51650 TSST-1 + strain, for ex- ample, was not able to induce septic arthritis, even though it was used in the adequate range of bacterial concentration ...
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Epidermal HLA DR and the enhancement of cutaneous reactivity to superantigenic toxins in psoriasis
... Streptococcal and staphylococcal superantigens (SAg’s) have been implicated in the pathogenesis of inflammatory skin diseases, but the mechanisms by which these toxins act are unknown. The present study assessed the ...
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Prevalence of Toxic Shock Syndrome Toxin 1 Producing Staphylococcus aureus and the Presence of Antibodies to This Superantigen in Menstruating Women
... human TSST-1 immunoglobulin G (IgG) ...a 1:64 dilution served as negative and positive controls, ...with TSST-1 ...by TSST-1. All such sera (diluted 1:4) yielded an ...
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Staphylococcus aureus Exotoxins Are Present In Vivo in Tampons
... syringe, 1 ml of distilled water was added, and the contents were ...of TSST-1 ( g/section) was determined by semiquantitative West- ern immunoblot analysis, which allows for the detection of ...
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Molecular analysis of pyrogenic exotoxins from Streptococcus pyogenes isolates associated with toxic shock like syndrome
... This group includes the staphylococcal enterotoxin serotypes A to E SEA to SEE, the staphylococcal pyrogenic exotoxins A and B, toxic shock syndrome toxin type 1 TSST-1, and the streptoc[r] ...
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Immunoblots for detection of toxic shock syndrome toxin 1 produced by Staphylococcus aureus
... Colony immunoblot assay for the detection of staphylococcal toxic shock syndrome toxin 1 TSST-1 with anti-TSST-1 Fab'2 fragments.. Rapid screening assay for toxic shock syndrome toxin pr[r] ...
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Toxic Shock Syndrome Toxin 1 Evaluation and Antibiotic Impact in a Transgenic Model of Staphylococcal Soft Tissue Infection
... to TSST-1-producing CC30 Staphylococcus aureus, is the leading manifestation of toxic shock syndrome ...treatment. TSST-1 sensitivity was estab- lished using murine spleen cell proliferation ...
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