Tubulointerstitial Fibrosis
CTGF siRNA ameliorates tubular cell apoptosis and tubulointerstitial fibrosis in obstructed mouse kidneys in a Sirt1-independent manner
... renal fibrosis by inhibiting the TGF-β1 ...interstitial fibrosis and apoptosis was ...of fibrosis-related ...and tubulointerstitial fibrosis, but did not affect Sirt1 expression and ...
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Targeted disruption of TGF β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
... against tubulointerstitial fibrosis following UUO as evi- denced by blocking of EMT and abrogation of monocyte influx and collagen ...interstitial fibrosis and suggest that inhibitors of this path- ...
10
CDK5 promotes renal tubulointerstitial fibrosis in diabetic nephropathy via ERK1/2/PPAR γ pathway
... promotes tubulointerstitial fibrosis (TIF) via the extracellular signal-regulated kinase 1/2 (ERK1/2)/peroxisome proliferator-activated receptor gamma (PPRAγ) pathway in ...and fibrosis via ...
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MicroRNA-27a promotes renal tubulointerstitial fibrosis via suppressing PPARγ pathway in diabetic nephropathy
... MicroRNA-27a (miR-27a) upregulation has been identified in diabetes, but the pathogenesis of miR-27a in renal tubulointerstitial fibrosis (TIF) in diabetic nephropathy (DN) has not been elucidated. Herein, ...
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Mesenchymal stem cell-derived microparticles ameliorate peritubular capillary rarefaction via inhibition of endothelial-mesenchymal transition and decrease tubulointerstitial fibrosis in unilateral ureteral obstruction
... significantly improved in vitro TGF-β1-treated HUVEC, partly mimicking the microenvironment of PTC in UUO mice kidneys. Thus, our present data are in strong support of the notion that PTC rarefaction can be significantly ...
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Delayed treatment with oleanolic acid attenuates tubulointerstitial fibrosis in chronic cyclosporine nephropathy through Nrf2/HO 1 signaling
... The cytoprotective effects of Nrf2 are supported by previous studies showing that Nrf2 gene ablation inten- sifies inflammation, oxidative stress and histological changes [9,10]. Oleanolic acid (OA), a known activator of ...
10
Whole-exome sequencing reveals genetic variants associated with chronic kidney disease characterized by tubulointerstitial damages in North Central Region, Sri Lanka
... Girandurukotte) was established in 2011 for the GWAS (methodology of the recruitment process and sample col- lection is mentioned in detail in our latest publication) [13]. CKDu cases are defined by the absence of known ...
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UMOD gene mutations in Chinese patients with autosomal dominant tubulointerstitial kidney disease: a pediatric case report and literature review
... now, no more than 2000 families have been reported world- wide [3]. The main clinical manifestations of ADTKD- UMOD include hyperuricemia and gout, some patients have mild urinary abnormalities. It usually develops to ...
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TGF-β promotes fibrosis after severe acute kidney injury by enhancing renal macrophage infiltration
... prevent fibrosis after severe renal ischemia/ reperfusion or obstructive injury (10), suggesting a role for increased TGF-β1 from nonmyeloid ...of fibrosis following severe ischemic ...
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Tubulointerstitial disease in diabetic nephropathy
... important tubulointerstitial fibrosis and/or arteriolar hyalino- sis, with glomerular sclerosis and relatively trivial abnormal ...erstitial fibrosis, an increase in kidney arteriolar resistance has ...
9
Urinary Hypoxia Inducible Factor 1alpha Levels Are Associated with Histologic Chronicity Changes and Renal Function in Patients with Lupus Nephritis
... Purpose: Tubulointerstitial hypoxia in the kidney is considered a hallmark of injury and a mediator of the progression of tubulointerstitial fibrosis. Hypoxia-inducible factor-1alpha (HIF-1alpha), a ...
6
Blockade of Oxidative Stress by Vitamin C Ameliorates Albuminuria and Renal Sclerosis in Experimental Diabetic Rats
... Diabetic nephropathy is a leading cause of end- stage renal disease. It is characterized functionally by proteinuria and albuminuria and pathologically by glomerular hypertrophy, mesangial expansion and ...
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Expression of vascular endothelial growth factor in the early stage of rats’ kidney with Chronic Allograft Nephropathy
... At 12 weeks, mesangial expansion, glomerulosclerosis and adhesions to Bowman‟s capsule, tubulopathy and interstitial mononuclear cells infiltration, intimal proliferation in allografts were found to be significantly ...
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Cystic fibrosis and the relevance of the whole body vibration exercises in oscillating platforms: a short review
... Objective: The aim is to present a review about the whole-body vibration (WBV) exercises in the management of cystic fibrosis (CF). Methods: Computerized literature searches were per- formed using the PubMed ...
7
Macrophage and Innate Lymphoid Cell Interplay in the Genesis of Fibrosis
... and fibrosis, ILC1 has not yet been formally implicated in the pathogenesis of fibrosis, while ILC3 is also associated with the development of fibrosis and is elevated in the bronchoalveloar lavage ...
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Gene Expression and Stereologic Analysis of Tubulointerstitial Remodeling in a Rodent Model of Chronic Proteinuria.
... The next urinary biomarker, OPN, is upregulated in proteinuria (Ohse, 2006), anti- GBM disease (Kastner, 2009), aging (Liang, 1995), and nephrotoxicity due to gentamicin (Rouse, 2011), vancomycin, bacitracin, or ...
175
Effect of steroids and relevant cytokine analysis in acute tubulointerstitial nephritis
... Figure 1 shows the Kaplan–Meier curves of the rate of renal recovery and risks of ESRD and mortality depend- ing on the use of steroids. None of the renal outcomes, including renal recovery and the risks of ESRD and ...
10
Acute tubulointerstitial nephritis complicating Legionnaires' disease: a case report
... Introduction: Legionnaires ’ disease is recognized as a multi-systemic illness. Afflicted patients may have pulmonary, renal, gastrointestinal tract and central nervous system complications. However, renal insufficiency ...
6
Local CD34-positive capillaries decrease in mouse models of kidney disease associating with the severity of glomerular and tubulointerstitial lesions
... marker of endothelial cells, significantly and negatively correlated with serum levels of autoantibody and deteri- oration in renal function, as well as increased numbers of infiltrating cells in the glomeruli. TILs in ...
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Simultaneous occurrence of IgG4-related Tubulointerstitial nephritis and colon adenocarcinoma with hepatic metastasis: a case report and literature review
... Case presentation: A 71-year-old Chinese man presented with dysuria and was initially diagnosed as benign prostatic hyperplasia for one year. He was admitted to the hospital for surgery. After admission, the renal ...
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