tumor antigens
Translating Tumor Antigens into Cancer Vaccines
... “undefined” antigens takes into account the heat shock proteins (HSPs), which are ubiquitous, intracellular molecular protein chaperons whose expression increases under conditions of elevated tempera- tures and ...
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Antigen specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma
... of tumor-infiltrating Tregs correlate with reduced ...the tumor antigens recognized by Tregs in cancer patients and the impact of these cells on tumor-specific T cell responses have not been ...
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Lymphocytes genetically modified to express tumor antigens target DCs in vivo and induce antitumor immunity
... of tumor-associated antigens may improve the immunogenic potential and clinical efficacy of DC-based cancer ...self/tumor antigens, acting as antigen carriers, efficiently target DCs in vivo ...
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Association of Simian Virus 40 Vp1 with 70-Kilodalton Heat Shock Proteins and Viral Tumor Antigens
... two tumor antigens, separately or simultaneously, to chap- erone Vp1 core folding in cooperation with the HSP70 protein in the ...T antigens (the LT-unique segment and the ST-unique ...T ...
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Coordinated responses to individual tumor antigens by IgG antibody and CD8+ T cells following cancer vaccination
... human tumor antigens [6, ...the tumor challenge and in vitro experi- ments already presented ...outlier antigens of interest for final IgG array experiments paired with IFNγ T cell ...
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Tumor antigens as proteogenomic biomarkers in invasive ductal carcinomas
... Tumor antigens (TAs) are tumor proteins that, when expressed in tumors, are recognized by the host immune ...(tumor-specific antigens) that arise from mutation or RNA ...[20]. ...
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Relationship between the methionine tryptic peptides of simian virus 40 and BK virus tumor antigens.
... In view of the differences protein was estimated to be 113,000 daltons in in molecular weight of the BKV T Ag's from our acrylamide gels, using as molecular weight transformed and lyrica[r] ...
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The generation and analyses of a novel combination of recombinant adenovirus vaccines targeting three tumor antigens as an immunotherapeutic
... MUC1 (CD227) is a TAA that is overexpressed on a majority of human carcinomas and several hematologic malignancies [38–41]. MUC1 is normally expressed at the surface of glandular epithelial cells [42] and, in carcinomas, ...
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Effects of Simian Virus 40 Large and Small Tumor Antigens on Mammalian Target of Rapamycin Signaling: Small Tumor Antigen Mediates Hypophosphorylation of eIF4E-Binding Protein 1 Late in Infection
... Western analysis. The procedures for Western analysis and the preparation of cellular extracts for Western analysis have been previously described (36). The vendor catalogue numbers for each purchased antibody are ...
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Expression of tumor antigens on primary ovarian cancer cells compared to established ovarian cancer cell lines
... of antigens frequently expressed at intermediate levels, p53, WT1 and Her-2/neu have been currently tested in clinical trials as promising targets of ovarian cancer ...different tumor types including ...
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Original Article Expression of MAGE-A3 and/or PRAME tumor antigens in South Korean gastric cancer patients
... Abstract: MAGE-A3 (Melanoma AntiGen-A3) and PRAME (Preferentially expressed Antigen of MElanoma) are two tumor-associated antigens (TAAs) which have been extensively tested to develop antigen-specific ...
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Identification of adenovirus 12-encoded E1A tumor antigens synthesized in infected and transformed mammalian cells and in Escherichia coli.
... The conclusion that the immunoprecipitated proteins are the Adl2 ElA T antigens is supported by: i the specific inhibition of the immunoprecipitation reaction by peptide 204; ii the appa[r] ...
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Insight into Merkel Cell Polyomavirus Replication Through the Study of the Viral Early Proteins: Large and Small Tumor Antigens
... Another MCPyV early protein is called small tumor antigen (sT), which shares the first N-terminal 78 amino acids with LT. This 186-amino acid protein is thought to play a more critical role in oncogenesis than LT. ...
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Human adenovirus 2 E1B-19K and E1B-53K tumor antigens: antipeptide antibodies targeted to the NH2 and COOH termini.
... Immunoprecipitation of Ad2 E1B-53K and EIB-19K T antigens from extracts of [35S]methioninelabeled Ad2-transformed F4 cells by antipeptide antibody targeted to the NH2 peptide 2, eight-am[r] ...
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Multiple forms of polyoma virus tumor antigens from infected and transformed cells.
... Because a 63,000-dalton protein was immunoprecipitated from both productively infected and transformed cells, the possibility existed that these proteins were related to the large and/or[r] ...
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Tumor Antigens Discovery: Perspectives for Cancer Therapy
... (1994) Identification of the immunodominant peptides of the MART- I human melanoma antigen recognized by the majority of HLA-A2 restricted tumor infiltrating lymphocytes. Sensi M, Traver[r] ...
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Functional role of BK virus tumor antigens in transformation.
... 4613 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest We have examined the role of the human papovavirus BK virus BKV tumor T antigens in the maintenance of transformati[r] ...
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Theranostic pretargeted radioimmunotherapy of internalizing solid tumor antigens in human tumor xenografts in mice: Curative treatment of HER2-positive breast carcinoma
... BsAb: bispecific antibody; BUN: blood urea nitrogen; CA: clearing agent CR: complete responses; CREA: creatinine; HGB: hemoglobin; IHC: immunohistochemistry; IA: injected activity; i.v.: intraveneous; %IA/g: percent ...
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Simian Virus 40-Induced T and Tumor Antigens
... The major component of the SV40 tumor antigen extracted from transplanted hamster tumors was identified at a position in centrifuged linear sucrose gradients corresponding to a molecular[r] ...
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Monoclonal antibodies specific for simian virus 40 tumor antigens.
... Several of the monoclonal antibodies from the L series hybridomas recognized determinants that were present on a subset of the large-T antigen from simian virus 40-transformed mouse cell[r] ...
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