Tumor associated antigen
Quantitative detection of the tumor-associated antigen large external antigen in colorectal cancer tissues and cells using quantum dot probe
... external antigen (LEA) is a cell surface glycoprotein that has been proven to be highly expressed in colorectal cancer (CRC) as a tumor-associated ...significantly associated with a more ...
13
The tumor-associated antigen RHAMM (HMMR/CD168) is expressed by monocyte-derived dendritic cells and presented to T cells
... the tumor-associated antigen (TAA) Wilms’ tumor 1 (WT1) by mRNA electroporation can induce clinical responses in AML patients with very limited side effects ...
11
The tumor associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8+ T cells
... CTLs eliminate virus-infected and tumorigenic cells through exocytosis of cytotoxic agents from lytic granules. While insights into the intracellular mechanisms facilitating lytic granule release have been obtained ...
21
HCA519/TPX2: a potential T-cell tumor-associated antigen for human hepatocellular carcinoma
... HCC tumor tissue compared to adjacent nontumor ...HCC tumor cell population as a whole might be sufficiently reduced, thereby hindering the in vivo tumor growth and in turn providing the patient ...
10
Apoptotic function of tumor associated antigen RCAS1 in oral squamous cell carcinoma
... was associated with response to treatments in patients with uterine and ovarian ...was associated with im- portant clinicopathological parameters for patient’s man- agement and prognosis ...of tumor ...
10
Tumor-associated antigen CAPER and microvessel density in hepatocellular carcinoma
... of tumor but might demonstrate higher prevalence in some tumors than ...human tumor cell lines derived from 9 different organs and made solubilized extracts from these cell lines to determine expression of ...
11
New perspective on targeting the tumor suppressor p53 pathway in the tumor microenvironment to enhance the efficacy of immunotherapy
... the tumor suppressor p53 ( p53 or Trp53 ) ...often associated with the stabilization and accumulation of mutant p53 ...ideal tumor associated antigen (TAA) for cancer ...to tumor ...
11
Adjuvant dendritic cell vaccination induces tumor-specific immune responses in the majority of stage III melanoma patients.
... However, since tumor-associated antigen TAA-specific T cells are detected in only a minority of the peripheral blood samples, and to date no correlation has been found between immunologic[r] ...
10
Distinct immune signatures in directly treated and distant tumors result from TLR adjuvants and focal ablation
... releasing tumor-associated antigen [7-9] and endogenous danger signals [10], increasing tumor infiltrating lymphocytes and antigen presenting cells [11, 12], and reducing tumor ...
18
Shikonin enhances efficacy of a gene-based cancer vaccine via induction of RANTES
... Chemotactic-tumor associated antigen vaccines have been reported to target specific antigens to special immune cell types, and thereby elicit improved immune responses ...a tumor-specific ...
12
Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses
... the tumor mass (33), and recent studies suggest that the T cells in long-term survivors with pancreatic cancer target neoantigens ...clearly associated with enhanced antitumor ...was associated with ...
18
Repeated episodes of spontaneous regression/progression of cervical adenocarcinoma after adjuvant chemoradiation therapy: a case report
... Many tumor cells express PD-L1 and protect themselves from the body’s immune ...and tumor progression; when the anti-tumor response of the immune system became pre- dominant, the cancer regressed, ...
5
Genomics of response to immune checkpoint therapies for cancer: implications for precision medicine
... against tumor cells, have shown immense promise in the treatment of various ...Currently, tumor mutational burden (TMB) and programmed death ligand 1 (PD-L1) expression are the primary biomarkers evaluated ...
18
Molecular Expression Analysis of Restrictive Receptor for Interleukin 13, a Brain Tumor-associated Cancer/Testis Antigen
... The search of the SEREX database (www.licr.org, University of Saarland, Hom- burg, Germany) failed to match IL13R with any known SEREX or testis/cancer antigen. This may be due to several reasons. First, the ...
10
T Cells Bearing a Chimeric Antigen Receptor Against the Tumor Vasculature Destroy the Tumor Endothelium and Result in Tumor Regression
... VEGF tumor cells engineered to express ...with tumor fluorescent radiant efficiency (Figure 20a–e), indicating that the exogenous endothelial cells expanded proportionally to the tumor ...this ...
127
In vitro cytotoxicity against Marek's disease lymphoblastoid cell lines after enzymatic removal of Marek's disease tumor-associated surface antigen.
... Cell-mediated cytotoxic response to cells bearing Marek's disease tumor-associated surface antigen in chickens infected with Marek's disease virus.. Development of cell-mediated immunity[r] ...
6
Enhanced stimulation of anti-breast cancer T cells responses by dendritic cells loaded with poly lactic-co-glycolic acid (PLGA) nanoparticle encapsulated tumor antigens
... of tumor lysate antigen obtained from three stage III breast cancer tissues encapsulated within PLGA NPs to enhance the DC maturation was ...generate tumor lysate antigens containing poly ...
11
PLGA nanoparticle-mediated delivery of tumor antigenic peptides elicits effective immune responses
... Poly(D,L-lactide-co-glycolide) (PLGA, molecular weight 23,000, copolymer ratio 50:50) was purchased from Birmingham Polymers, Inc (Birmingham, AL). Polyvinyl alcohol (PVA, average molecular weight 30,000–70,000), ...
13
Down-regulation of the cancer/testis antigen 45 (CT45) is associated with altered tumor cell morphology, adhesion and migration
... The CT45 gene family was first identified in 2005 by signature sequencing and comprises 6 highly similar genes which are located on the X-chromosome (Xq26.3) [10]. CT45 is a nuclear protein with significant similarity to ...
12
Medium tumor antigen of polyomavirus transformation-defective mutant NG59 is associated with 73-kilodalton heat shock protein.
... WELCH2 Department of Pathology, University of California, San Diego, La Jolla, California 92093,1 and Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 117242 Received 8 August[r] ...
6