Tumor-associated antigens
<p>T cells targeting multiple tumor-associated antigens as a postremission treatment to prevent or delay relapse in acute myeloid leukemia</p>
... leukemia- associated antigens (LAAs) which can recognize and kill AML ...multiple tumor-associated antigens (TAAs) (PRAME, SSX2, MAGEA4, NY-ESO-1, and Survivin), Ann Leen et al treated ...
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A high throughput method for identifying personalized tumor- associated antigens
... against tumor-associated antigens (TAAs) and their pattern of glycosylation can be used as diagnostic indicators of ...identifying tumor-associated antigens represented by ...
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Autoantibodies to tumor-associated antigens as biomarkers in human hepatocellular carcinoma (HCC)
... Tumor-associated antigens (TAAs) recognized by cellular and/or humoral effectors of the immune system are attractive targets for diagnostic and therapeutic approaches to human ...be associated ...
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Diagnosis of cutaneous T cell lymphoma by use of monoclonal antibodies reactive with tumor associated antigens
... determined by radioimmunoassay (RIA) and indirect immunofluorescence (IIF). BE1 reacted significantly (P less than or equal to 0.001) with leukemic CTCL lymphocytes and with CTCL cells from infiltrated lymph nodes (RIA, ...
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A therapeutic T cell receptor mimic antibody targets tumor associated PRAME peptide/HLA I antigens
... including tumor-specific mutations, glycosylation patterns, and gene expression signatures, the vast majority of these cancer-specific markers and tumor-associated antigens can- not currently ...
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Dendritic cells pulsed with generated tumor cell lysate from Phyllanthus amarus Schum & Thonn induces anti tumor immune response
... apoptotic tumor cells lysate have been used suc- cessfully to induce tumor vaccination ...whole tumor cell lysate represents a rich source of antigens with epitopes for CD8 + cytotoxic T cells ...
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CD8 T cell response in a phase I study of therapeutic vaccination of advanced NSCLC with allogeneic tumor cells secreting endoplasmic reticulum chaperone gp96 Ig peptide complexes
... the tumor has evaded immune ...of tumor associated antigens that can anergize antigen specific T cells and the tumor often mediates active immune sup- pression favoring tumor ...
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Immunologic Approaches to Breast Cancer Treatment
... Given the success of Herceptin, there has been considerable work in creating Her-2/neu vaccines [88]. Immunization with a HER-2/neu vaccine can result in DTH peptide-specific responses in skin and specific T-cell responses ...
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Bridging infectious disease vaccines with cancer immunotherapy: a role for targeted RNA based immunotherapeutics
... melanoma antigens was shown to be safe and feasible with one complete remission ...peptide-based tumor vaccines re- quire strong adjuvants to induce immunity, non-coding long chain RNA-based adjuvants were ...
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CSPG4: a prototype oncoantigen for translational immunotherapy studies
... several tumor associated antigens (TAA), a more rational design and more sophisticated strategies for anti-tumor vaccination have been ...by tumor cells, tumor microenvironment ...
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Immune mechanisms in alcoholic liver disease
... against antigens derived from oxidatively damaged hepatocytes ...stress-derived antigens to CD4 ? T-cell, as HSC are efficient antigen-presenting cells [81] and have the capability to internalize oxidation ...
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Management of patients with non-Hodgkin’s lymphoma: focus on adoptive T-cell therapy
... Still, major technical issues persist for the widespread application of this technology. One example is the mispairing phenomenon. Indeed, the surface expression of the desired TCRs can be hampered by the incorrect ...
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Safety of targeting tumor endothelial cell antigens
... of tumor antigens are introduced in an immunogenic context with the aim of eliciting tumor ...on tumor endothelial cell vaccines, by discussing the following topics: (a) Antigenic differences ...
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Tumor Antigens Discovery: Perspectives for Cancer Therapy
... (1994) Identification of the immunodominant peptides of the MART- I human melanoma antigen recognized by the majority of HLA-A2 restricted tumor infiltrating lymphocytes. Sensi M, Traver[r] ...
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Oncogenic cancer/testis antigens: prime candidates for immunotherapy
... of tumor immunology suggests that tumor antigen-negative variants may evolve as the result of immunologic pressure, and thus it would be beneficial to target antigens, which, if lost, would reduce ...
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A Therapeutic Approach To Cancer Gene Therapy
... destroy tumor cells, for example, the loss of tumor suppressor genes ...a tumor suppressor gene such as P53 by inserting a copy of the wild-type gene; in fact, insertion of the wild-type P53 gene ...
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Tumor antigens as proteogenomic biomarkers in invasive ductal carcinomas
... Tumor antigens (TAs) are tumor proteins that, when expressed in tumors, are recognized by the host immune ...(tumor-specific antigens) that arise from mutation or RNA ...[20]. ...
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Functional role of BK virus tumor antigens in transformation.
... 4613 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest We have examined the role of the human papovavirus BK virus BKV tumor T antigens in the maintenance of transformati[r] ...
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Simian Virus 40-Induced T and Tumor Antigens
... The major component of the SV40 tumor antigen extracted from transplanted hamster tumors was identified at a position in centrifuged linear sucrose gradients corresponding to a molecular[r] ...
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MUC1 and carbohydrate associated antigens in head and neck squamous cell carcinoma: our experience
... above, tumor MUC1 differs from that expressed in normal cells, both in its biochemical features and its cellular distribution as ...Tn/T antigens or overexpression of sLex/sLea ...
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