tumor exosomes
Recapitulating the Size and Cargo of Tumor Exosomes in a Tissue-Engineered Model
... of exosomes in cancer and in their use as ...of tumor cells still represent the main in vitro source of ...three-dimensional tumor model for studying exosomes, using Ewing’s sarcoma type 1 as ...
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CD44v6-competent tumor exosomes promote motility, invasion and cancer-initiating cell marker expression in pancreatic and colorectal cancer cells
... Exo: exosomes, FN: fibronectin, GEM: glycolipid-enriched membrane microdomains, HA: hyaluronic acid, HAS: HA synthase, HGF: hepatocyte growth factor, Hyal: hyaluronidase, ICD: intracellular domain, ...TEX: ...
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Tumor-exosomes and leukocyte activation: an ambivalent crosstalk
... of tumor-exosomes Binding and uptake of dye-labeled ASML-exosomes by leukocytes from central and peripheral lymphoid organs was evaluated by ...titrating exosomes from 10 μg/ml to 40 μg/ml and ...
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Lung tumor exosomes induce a pro-inflammatory phenotype in mesenchymal stem cells via NFκB-TLR signaling pathway
... that exosomes released by chronic lymphocytic leukemia could induce an inflammatory phenotype in stromal cells through activating AKT, ERK1/2, CREB, and GSK3α/β signaling pathways ...how tumor cell-derived ...
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Exosomes from human colorectal cancer induce a tumor-like behavior in colonic mesenchymal stromal cells
... in exosomes. Exosomes are nanovesicles of 50–150 nm in size, containing different cell metabolites, produced and exported by all cell ...types. Exosomes can be detected in all human body fluids ...
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The biology and function of exosomes in cancer
... Tumor exosomes and resistance to therapy. Exosomes are emerg- ing as a potential contributor to cancer progression, adding another dimension to the complexity of the tumor microenvi- ...cancer ...
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Tumor-derived exosomes in cancer progression and treatment failure
... All exosomes share common proteins or protein families, which could serve as exosome ...16-18]. Exosomes also contain various cell-specific proteins, depending on cellular origin and putative target ...
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The emerging roles of exosomes in leukemogeneis
... of exosomes in leukemia treatment comes mainly from its potential use in the loading of dendritic cells (DCs) [65], as drug delivery system or delivery vector for siRNA [66] or miRNA ...target tumor ...
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Circulating exosomes potentiate tumor malignant properties in a mouse model of chronic sleep fragmentation
... and tumor growth [11, 12]. Interactions between the tumor and its microenvironment ...modulate tumor cell survival and proliferation. It has been reported that tumor exosomes are ...
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Exosomes released by hepatocarcinoma cells endow adipocytes with tumor-promoting properties
... How exosomes cause significant cellular and mo- lecular changes in target cells remains an area of in- tensive ...HCC exosomes could deliver miR-1247-3p into fibroblasts and converted them into ...
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Exosomes in tumor microenvironment: novel transporters and biomarkers
... of exosomes or removing exosomes from the blood ...of exosomes in HeLa cells ...of exosomes from the limiting membrane of multivesicular endosomes), can inhibit exosome mediated tumor ...
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Chronic myeloid leukemia-derived exosomes promote tumor growth through an autocrine mechanism
... sustain tumor growth, we tested the expression of different molecules involved in the apoptotic ...that tumor exosomes are able to affect the balance between the pro- and anti- apoptotic ...
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Tspan8 and Tspan8/CD151 knockout mice unravel the contribution of tumor and host exosomes to tumor progression
... Exo: Exosomes; FAK: Focal adhesion kinase; FGF: Fibroblast growth factor; FITC: Fluorescence isothiocyanate; FN: Fibronectin; GPCR: G-protein-coupled receptor; GPI: Glycosylphosphatidylinositol; HGF: Hepatocyte ...
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Tumor cells derived exosomes contain hTERT mRNA and transform nonmalignant fibroblasts into telomerase positive cells
... of exosomes in the crosstalk between malignant cells and the tumor microenvironment has been documented ...via exosomes into “recipient” telomerase negative fibroblasts, where it is translated into a ...
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MicroRNA Profiling of Exosomes
... Exosomes are nano-sized membrane-bound vesicles released by a range of different cell ...types. Exosomes have been shown to specifi cally package certain membrane and cytosolic proteins and nucleic ...
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Exosomes as mediators of neuroinflammation
... [7,8], exosomes are formed by the inward budding of the limiting mem- brane of the late endosome, and encapsulate cellular proteins, RNA as well as miRNAs from the cytoplasm in a non-random fashion ...the ...
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Blood TfR+ exosomes separated by a pH-responsive method deliver chemotherapeutics for tumor therapy
... in tumor cells was ...effective tumor inhibition ...after tumor cells were respectively treated with DOX and D-M-EXOs for 48 ...the tumor cell inhibition effect of DOX, they could improve the ...
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Original Article High-grade ovarian cancer secreting effective exosomes in tumor angiogenesis
... cal tumor due to a late diagnose, high recur- rence and lack of effective medicine ...therapy. Exosomes have been found in biological fluids and have a series of typical proteins, lipids and RNAs com- ...
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Exosomes from glioma cells induce a tumor-like phenotype in mesenchymal stem cells by activating glycolysis
... Two-dimensional gel electrophoresis and image analysis 2-DE was performed as described previously [21–23]. Briefly, after treatment with 300 μg/mL U251 cell-derived exosomes for 48 h, hBMSCs were harvested and ...
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Suppression of endothelial cell migration by tumor associated macrophage-derived exosomes is reversed by epithelial ovarian cancer exosomal lncRNA
... recently, exosomes have been identified as very important mechanisms for crosstalk between various ...In tumor microenvironment, tumor cells and TAMs are the most important cell sources of ...
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